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Immunosuppression in established immune statesGagnon, R. F. January 1979 (has links)
No description available.
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152 |
Bystander T cell activationBangs, Sarah Christine January 2007 (has links)
T cell responses are subject to several layers of regulation in order to prevent a detrimental effect on the host. Bystander T cell activation occurs via TCR-independent mechanisms, and as such evades certain control checkpoints. The apparent irrationality of this concept, coupled with the finding that the overwhelming majority ofT cells activated during viral infection are antigen-specific, has lead to a debate over the existence of the phenomenon. In this study, I sought to build upon previous work with murine models, to demonstrate the existence of bystander T cell activation in primary human T cells following initial stimulation of a distinct population of antigen-specific T cells with staphylococcal enterotoxin B (SEB). Furthermore, it has been established that this occurs in the absence of any opportunity for TCR cross-reactivity. Further investigation was made into the mechanism of activation, and the phenotype and function of bystander activated T cells. Phenotypic analysis indicated that bystander T cell activation in the SEB system occurred preferentially within a particular T cell subset. Distinct characteristics were identified amongst directly activated T cells and bystander activated T cells. The functional outcome with regards to proliferative capacity, apoptosis induction, and suppression by regulatory T cells was also investigated, Microarray analysis of resting, bystander, and directly activated T cells revealed distinct gene expression profiles, and analysis of differentially expressed genes supported an absence of TCR stimulation within the bystander population. Data furthermore indicated distinct mechanisms of apoptosis for bystander and directly activated T cells. Candidate cytokines implicated by the data were followed up with neutralisation assays. Taken together, the data support the hypothesis that bystander T cell activation induces a partial activation state in a proportion of memory T cells, which is followed by apoptosis, which may provide immunological space for newly generated antigen-specific memory T cells, while eroding pre-existing memory populations.
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153 |
An Immunological Characterisation of Drosophila Cell Lines and the Effects of Hormones on Cell LinesMoir, A. January 1974 (has links)
No description available.
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154 |
Monoclonal antibodies for analysis of the HLA systemBrodsky, F. M. January 1979 (has links)
No description available.
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155 |
The Relationship between Adjuvant Activity and Cell Wall Structure in the Family MycobacteriaceaeMcLure, A. R. January 1976 (has links)
No description available.
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156 |
The immunogenicity of staphylococcal delta-haemolysinStearne, L. E. T. January 1979 (has links)
No description available.
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157 |
Studies on surface antigens of trypanosoma BruceiBarry, J. D. January 1977 (has links)
No description available.
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158 |
Antigenic Analysis of Yeast Cell-Walls as an Aid to ClassificationJones, G. R. January 1974 (has links)
No description available.
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159 |
Control of the quantity and quality of antibody biosynthesis in the domestic fowlSmillie, D. M. January 1976 (has links)
No description available.
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160 |
Identification of antibody V genes and study of their expression in natural and immune antibodiesCattan, A. R. January 1979 (has links)
No description available.
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