NDLTD Global ETD Search
  • Refine Query
  • Source
  • Publication year
  • to
  • Language
  • 4
  • 2
  • Tagged with
  • 41
  • 2
  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • About
  • The Global ETD Search service is a free service for researchers to find electronic theses and dissertations. This service is provided by the Networked Digital Library of Theses and Dissertations.
    Our metadata is collected from universities around the world. If you manage a university/consortium/country archive and want to be added, details can be found on the NDLTD website.

Search results

Showing 11 to 20 of 41 (0.008 seconds)
11

Role of acylation domain in the function of LCK

Pirinen, Niina Johanna January 2005 (has links)
No description available.
572.69
12

Using a binding protein as a scaffold for designer catalysts

McDonald, Rhona E. January 2004 (has links)
No description available.
572.69
13

Functional analysis of Maestro, a candidate sex-determining gene

Willan, John January 2005 (has links)
No description available.
572.69
14

Glycosaminoglycan interactions with the tissue inhibitors of metalloproteinases

Dodds, Philippa January 2004 (has links)
No description available.
572.69
15

Structural studies of small heat shock proteins and eye lens crystallins

Srikanthan, Durga January 2005 (has links)
No description available.
572.69
16

A formal synthesis of garsubellin A via bridgehead substitution

Ahmad, Nadia Mamoona January 2006 (has links)
No description available.
572.69
17

The lectin pathway of complement activation

Presanis, Julia January 2004 (has links)
No description available.
572.69
18

Structural bioinformatics and simulation studies of α-helical membrane proteins

Cuthbertson, Jonathan M. January 2005 (has links)
No description available.
572.69
19

The solution structure and functional studies on the hyaluronan binding site

Teriete, Peter January 2004 (has links)
No description available.
572.69
20

NMR structure of the S-domain of calreticulin, the sub-fragment that comprises the calreticulin binding site for defence collagens

Gingras, Alexandre R. January 2004 (has links)
Using the overlapping sub-fragments, i.e. P-, S- and SP-domains of CRT in different binding assays, we determined that the S-domain has the strongest affinity to bind to C1q and MBL. This makes the structure of the S-domain most relevant for understanding the binding interactions to C1q and MBL and the sterical inhibition of the complement activation by competing with the respective C1q or MBL associated serine proteases for binding. The CRT S-domain structure determined in this work has an extended hairpin fold stabilised by a short 3 residues beta-sheet holding the two opposite strands together. Two hydrophobic cores, each containing two conserved tryptophan residues, are located on either sides of this beta-sheet and further stabilise this fold. Comparison of 2D [1H, 15N]-HSQC spectra indicated higher internal mobility of the S-domain than of the other active fragments, suggesting that the dynamical properties are important for the protein activity. Detailed multi-field relaxation analysis showed high dynamics in the hairpin with more restrictions where secondary structure elements are present. The interaction with MBL and C1q was determined to be optimal under low ionic strength conditions, indicative of electrostatic interactions.;The interaction probably involves the tip of the hairpin in the CRT S-domain structure that has a high concentration of negatively charged residues, and a complimentary positively charged region of the MBL and C1q collagen-like domains. The flexibility of the hairpin is likely to be a key element for CRT, allowing it to adopt its conformation for binding to multiple ligands and is expected to be the key factor for the enhanced activity of the S-domain.
572.69

Page generated in 0.0121 seconds