Network optimization plays an important role in 5G/next-G networks, which requires knowledge of network parameters (e.g., channel state information). The majority of existing works assume that all network parameters are either given a prior or can be accurately estimated. However, in many practical scenarios, some parameters are uncertain at the time of allocating resources and can only be modeled by random variables. Further, we only have limited knowledge of those uncertain parameters. For instance, channel gains are not exactly known due to channel estimation errors, network delay, limited feedback, and a lack of cooperation (between networks). Therefore, a practical solution to network optimization must address such uncertainty inside wireless networks. There are three approaches to address such a network uncertainty: stochastic programming, worst-case optimization, and chance-constrained programming (CCP). Among the three, CCP has some unique benefits compared to the other two approaches. Stochastic programming explicitly requires full distribution knowledge, which is usually unavailable in practice. In comparison, CCP can work with various settings of available knowledge such as first and second order statistics, symmetric properties, or limited data samples. Therefore, CCP is more flexible to handle different network settings, which is important to address problems in 5G/next-G networks. Further, worst-case optimization assumes upper or lower bounds (i.e., worst cases) for the uncertain parameters and it is known to be conservative due to its focus on extreme cases. In contrast, CCP allows occasional and controllable violations for some constraints and thus offers much better performance in resource utilization compared to worst-case optimization. The only drawback of CCP is that it may lead to intractability due to its probabilistic formulation and limited knowledge of the underlying random variables. To date, CCP has not been well utilized in the wireless communication and networking community. The goal of this dissertation is to extend the state-of-the-art of CCP techniques and address a number of challenging network optimization problems. This dissertation is correspondingly organized into two parts. In the first part, we assume the uncertain parameters are only known by their mean and covariance (without distribution knowledge). We assume these statistics are rather stationary (i.e., time-invariant for a sufficiently long time) and thus can be accurately estimated. In this setting, we introduce a novel reformulation technique based on the mean and covariance to derive a solution. In the second part, we assume these statistics are time-varying and thus cannot be accurately estimated.In this setting, we employ limited data samples that are collected in a small time window and use them to derive a solution. For the first part, we investigate four research problems based on the mean and covariance of the uncertain parameters: - In the first problem, we study how to maximize spectrum efficiency in underlay coexistence.The interference from all secondary users to each primary user must be kept below a given threshold. However, there is much uncertainty about the channel gains between the primary users and the second users due to a lack of cooperation between them. We formulate probabilistic interference constraints using CCP for the primary users. For tractability, we introduce a novel and powerful reformulation technique called Exact Conic Reformulation (ECR). With limited knowledge of mean and covariance, ECR offers an equivalent reformulation for the intractable chance constraints with tractable deterministic constraints without relaxation errors. After reformulation, we employ linearization techniques to the mixed-integer non-linear problem to reduce the computation complexity. We show that our proposed approach can achieve near-optimal performance and stands as a performance benchmark for the underlay coexistence problem. - To find a solution for the same underlay coexistence problem that can be used in the real world, we need to find a solution in "real-time". The real-time requirement here refers to finding a solution in 125 us (the minimum time slot for small cells in 5G). Our proposed solution has three steps. First, it employs ECR to reformulate the original CCP into a deterministic optimization problem. Then it decomposes the problem and narrows down the search space into a smaller but promising one. By random sampling inside the promising search space and through local search, our proposed solution can meet the 125 us requirement in 5G while achieving 90% optimality on average. - We further apply CCP, predicated on the reformulation technique ECR, to two other problems. * We study the problem of power control in concurrent transmissions. Our objective is to maximize energy efficiency for all transmitter-receiver pairs with capacity requirements. This problem is challenging due to mutual interference among different transmitter-receiver pairs and the uncertain channel gain between any transmitter and receiver. We formulate a CCP and reformulate it into a deterministic problem using ECR. Then we employ Geometric Programming (GP) with a tight approximation to derive a near-optimal solution. * We study task offloading in Mobile Edge Computing (MEC) where the number of processing cycles of a task is unknown until completion. The goal is to minimize the energy consumption of the users while meeting probabilistic deadlines for the tasks. We formulate the probabilistic deadlines into chance constraints and then use ECR to reformulate them into deterministic constraints. We propose a solution that consists of periodic scheduling and schedule updates to choose the offloaded tasks and task-to-processor assignments at the base station. In the second part, we investigate two research problems based on limited data samples of the uncertain parameters: - We study MU-MIMO beamforming based on Channel State Information (CSI). The goal is to derive a beamforming solution---minimizing power consumption at the BS while meeting the probabilistic data rate requirements of the users---by using very limited CSI data samples. For our CCP formulation, we explore the idea of Wasserstein ambiguity set to quantify the distance between the true (but unknown) distribution and the empirical distribution based on the limited data samples. Our proposed solution---Data-Driven Beamforming (D^2BF)---reformulates the CCP into a non-convex deterministic optimization problem based on the properties of Wasserstein ambiguity set. Then D^2BF employs a novel convex approximation to the non-convex deterministic problem, which can be directly solved by commercial solvers. - For a solution to the MU-MIMO beamforming to be useful in the real world, it must meet the "real-time" requirement. Here, the real-time requirement refers to 1 ms, which is one transmission time interval (TTI) under 5G numerology 0. We present ReDBeam---a Real-time Data-driven Beamforming solution for the MU-MIMO beamforming problem (minimizing power consumption while offering probabilistic data rate guarantees to the users) with limited CSI data samples. RedBeam is a parallel algorithm and is purposefully designed to take advantage of the vast parallel processing capability offered by GPU. ReDBeam generates a large number of initial solutions from a promising search space and then refines each solution by a local search. We show that ReDBeam meets the 1 ms real-time requirement on a commercial GPU and is orders of magnitude faster than other state-of-the-art algorithms for the same problem. / Doctor of Philosophy / Network optimization plays an important role in 5G/next-G networks. In a wireless network optimization problem, we typically want to maximize or minimize an objective function under a set of performance or resource constraints. Knowledge of network parameters is typically required in these problems. The majority of existing works assume that all network parameters are either given a prior or can be accurately estimated. However, in many practical scenarios, some parameters are uncertain in nature and cannot be accurately estimated beforehand. This dissertation addresses uncertainty in wireless network optimizations using chance-constrained programming (CCP). CCP can work with limited knowledge of uncertain parameters such as statistics or data samples, instead of full distribution information. In a CCP formulation, violations of certain target performance or requirement thresholds are expressed as probabilistic constraints and the frequency of such violations is bounded through a risk parameter. By changing this risk level, CCP offers a unique trade-off between the guaranteed threshold violation probabilities and the achieved objective value. The only drawback of CCP is that it may lead to intractability due to its probabilistic formulation and limited knowledge of the underlying random variables. The goal of this dissertation is to extend the state-of-the-art of CCP techniques to address a number of challenging network optimization problems. This dissertation is organized into two parts. In the first part, the mean and covariance of the uncertain parameters are assumed to be stationary and thus can be accurately estimated. Our main contribution is a novel reformulation technique for CCP called Exact Conic Reformulation (ECR). Based on knowledge of mean and covariance, ECR is able to offer an equivalent reformulation for the intractable chance constraints with tractable deterministic constraints without relaxation errors. We apply CCP, predicated on ECR, to address three problems: (i) scheduling and power control in underlay coexistence; (ii) power control in concurrent transmissions, and (iii) task offloading in Mobile Edge Computing (MEC). For the first problem, we further address the "real-time" requirement in a solution and propose a solution that can meet the stringent timing requirement. In the second part, when the uncertain parameters are non-stationary and their statistics cannot be accurately estimated, we propose to employ limited data samples that are collected over a small window and use them to develop a solution. To demonstrate the efficacy of this approach, we investigate the MU-MIMO beamforming problem that minimizes the power consumption of the base station while providing probabilistic guarantees to users' data rates. We further address the timing requirement for such a solution in practice, and present a real-time data-driven beamforming solution for MU-MIMO.