3-D computational modelling of the human spine provides a sophisticated and cost-effective medium for bioengineers, researchers, and ergonomics designers in order to study the biomechanical behaviour of the human spine under different loading conditions. Developing a generic parametric computational human spine model to be employed in biomechanical modelling introduces a considerable potential to reduce the complexity of implementing and amending the intricate spinal geometry. The main objective of this research is to develop a 3-D parametric human spine model generation framework based on a command file system, by which the parameters of each vertebra are read from the database system, and then modelled within commercial 3-D CAD software. A novel data acquisition and generation system was developed as a part of the framework for determining the unknown vertebral dimensions, depending on the correlations between the parameters estimated from existing anthropometrical studies in the literature. The data acquisition system embodies a predictive methodology that comprehends the relations between the features of the vertebrae by employing statistical and geometrical techniques. Relations amongst vertebral parameters such as golden ratio were investigated and successfully implemented into the algorithms. The validation of the framework was carried out by comparing the developed 3-D computational human spine models against various real life human spine data, where good agreements were achieved. The constructed versatile framework possesses the capability to be utilised as a basis for quickly and effectively developing biomechanical models of the human spine such as finite element models.