141 |
Signal transduction pathways integrating proliferation (self-renewal) and adhesion by haematopoietic progenitor cellsNteliopoulos, Georgios January 2010 (has links)
No description available.
|
142 |
The role of ischaemia-reperfusion on neutrophil activation in healthy humansAmoah, Vincent January 2008 (has links)
Ischaemia-reperfusion injury is a common clinical event, still associated with high mortality and morbidity, and lacks a specific therapy. It is well established that postischaemic reflow is associated with the generation ofoxygen radicals, and that oxidant stress occurring during reperfusion may produce deleterious effects in reperfused tissue. A consistent feature oflocal tissue injury that follows ischaemiareperfusion injury is the histological fmding ofan acute inflammatory response mediated in part by increased vascular permeability, mast cell degranulation, plugging ofthe microvasculature by circulating leukocytes, with a concomitant recruitment of adherent and emigrating leukocytes, release ofreactive oxygen species and proteolytic enzymes, increased albumin extravasation in downstream postcapillary venules, and cell death. Ofthe different circulating cells activated, experimental models ofischaemia-reperfusion have identified the polymorphonuclear leukocyte (neutrophil) as mediating the initiation reperfusion-induced tissue injury. Research on ischaemia-reperfusion injury has focused on either animal studies or patients who are hospitalised. There is limited research on ischaemia-reperfusion in healthy individuals. Therefore, the aim ofthe series ofstudies set out was to investigate the functional response ofleukocytes ofhealthy individuals in response to ischaemia-reperfusion and from the results obtained to develop a working model of the mechanism involved in ischaemia-reperfusion. Male Participants (n = 125) (mean age 22 ± 4) all considered healthy were recruited from the university student population and the general public to participate in the study. Participants were exposed to ischaemia-reperfusion for various durations. Venous whole blood samples taken from the anticubital vein were subjected to various assays including the use ofluminol-enhanced chemiluminescence, and enzyme-linked immunosorbent assay with the aim ofdetermining the role, if any, that neutrophils play in ischaemia-reperfusion. From the results obtained from the series of studies it was demonstrated that reactive oxygen species production and neutrophil priming activation occur as a result ofischaemia-reperfusion, interacting possibly with each other and with other elements such as endothelial cells and other leukocytes. Further investigation is required to elucidate the mechanisms involved that lead to neutrophil activation, which will allow for the development ofnovel treatment to be developed.
|
143 |
A coupled electromechanics model of the rat left ventricleNiederer, Steven Alexander January 2008 (has links)
No description available.
|
144 |
Pacemaker mechanisms of the guinea pig sino-atrial nodeSanders, Luke January 2008 (has links)
No description available.
|
145 |
Role of neuronal nitric oxide synthase in the regulation of B3- Adrenergic responses in the healthy and remodelled murine myocardiumIdigo, Winifred January 2008 (has links)
No description available.
|
146 |
Regulation of cardiac energetics in transgenic models and mitochondriaPhillips, Darci Joelle January 2008 (has links)
No description available.
|
147 |
Analysis of the role of nitric oxide in the control of blood flowAbatay, Hasan January 2010 (has links)
No description available.
|
148 |
Effects of hypoxia and diet on human cardiac energy metabolismHolloway, Cameron January 2009 (has links)
No description available.
|
149 |
Fluid-solid coupling for the simulation of left ventricular mechanicsNordsletten, David January 2009 (has links)
No description available.
|
150 |
Computational Modelling of Coronary Structure and Flow MechanicsLee, Jack January 2009 (has links)
No description available.
|
Page generated in 0.0152 seconds