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The Global ETD Search service is a free service for researchers
to find electronic theses and dissertations. This service is
provided by the
Networked Digital Library of Theses and Dissertations.
Our metadata is collected from universities around the world. If you manage a university/consortium/country archive and want to be added, details can be found on the NDLTD website.
Search results
Showing 1 to 10 of 17 (0.019 seconds)| 1 |
Growth, atresia and intercellular communication in the mouse and human ovarian follicleWright, Catherine Sarah January 2003 (has links)
No description available.
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Cellular mechanisms for the control of glucocorticoid metabolism by 11-beta hydroxysteroid dehydrogenase in the human ovaryJonas, Kim Carol January 2005 (has links)
The aims of this thesis were to: (i) determine the regulatory properties of human follicular fluid (FF) on the activities and expression of 11(3HSD, (ii) investigate the effects of progesterone on llpHSD activity and expression (iii) investigate the effects of prostaglandins on basal and endocrine-stimulated llpHSD activity and expression (iv) to predict the topology and tertiary structure of 11 pHSDl. Human FF contains hydrophilic and hydrophobic compounds that stimulate and inhibit, respectively, the NADP(H)-dependent activities of 11 pHSDl. The predominant lipid inhibitors of 11(3HSD1 in FF are unlikely to be steroids or prostaglandins, and the effects of the FF components on enzyme activities occur without changes in 11 PHSDl protein expression. Inhibition of progesterone production by aminoglutethimide increased 1 lpHSD activities, without affecting 1 lpHSDl protein expression in human granulosa-lutein cells. Pharmacological inhibitors of prostaglandin-H synthase (PGHS)-2 (meclofenamic acid (MA) and NS-398) decreased cortisol-cortisone inter-conversion by up to 50%, suggesting that prostaglandins may stimulate ovarian llpHSD activities in a paracrine/autocrine manner. Furthermore, PGHS-2 inhibitors prevented human chorionic gonadotrophin (hCG) and IL-1(3 from stimulating 11(3HSD activities in human granulosa-lutein cells, implicating eicosanoids in the stimulation of ovarian llpHSD by gonadotrophins and cytokines. Since MA and NS-398 had no effect on 1 IpHSDl protein expression, the stimulation of 11 pHSD activities by eicosanoids occurs at the post-translational level. Finally, the structure of 1 lpHSDl protein was modelled to develop molecular mechanisms by which prostaglandins, gonadotrophins and cytokines might regulate enzyme activities. Although the primary sequence of 1 lpHSDl, which is highly conserved across 10 mammalian species, contains several consensus phosphorylation sites for serine/threonine and tyrosine kinases, models of 11 pHSDl topology predict that most phosphorylation sites would lie in the lumen of the endoplasmic reticulum. 1 lpHSDl includes hydrophobic a-helices neighbouring the active site, which may provide regions for the allosteric control of glucocorticoid metabolism by progesterone and eicosanoids in ovarian cells.
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The role of mitogen-activated protein kinase in the regulation of progesterone production in human granulosa-lutein cellsDewi, Dian Amrita January 2002 (has links)
No description available.
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Changes in the cyclic-AMP / protein kinase A system and progesterone secretion during the luteinization of human granulosa cellsChin, Evonne Camla January 2003 (has links)
No description available.
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Characterisation of non-adrenergic non-cholinergic responses in the vaginal wallZiessen, Tom Menno January 2002 (has links)
No description available.
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Maternal factors influencing metabolic programming of the blastocyst within the uterine environmentPorter, Richard January 2005 (has links)
No description available.
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Insulin-like growth factor binding proteins as co-ordinators of human ovarian follicular functionWright, Rebecca Jane January 2003 (has links)
No description available.
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The control of initiation of ovarian follicle growthThorne, James January 2006 (has links)
No description available.
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The cellular origin of basal lamina components in the growing ovarian follicleRoger, Jan January 2005 (has links)
No description available.
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Understanding the hormonal process by which the human myometrial corticotrophin-releasing hormone (CRH)-R1a receptor is downregulated : a cell culture studyWoodman, Jacqueline Rachel January 2003 (has links)
No description available.
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