- About
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The Global ETD Search service is a free service for researchers
to find electronic theses and dissertations. This service is
provided by the
Networked Digital Library of Theses and Dissertations.
Our metadata is collected from universities around the world. If you manage a university/consortium/country archive and want to be added, details can be found on the NDLTD website.
Search results
Showing 1301 to 1310 of 4832 (0.042 seconds)| 1301 |
Studies on the nature and interrelationships of human plasminogen activatorsMackie, M. J. January 1979 (has links)
No description available.
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| 1302 |
Some Studies in the Clinical Pharmacology of Digoxin and Beta-Adrenergic Blocking DrugsCarruthers, S. G. January 1975 (has links)
No description available.
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| 1303 |
Cardiovascular effects of some antiarrhythmic drugsZaidi, S. A. January 1972 (has links)
No description available.
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| 1304 |
Development, characterisation and processing of supersaturating celecoxib solid dispersions for oral drug delivery using hot-melt extrusionBrannigan, Timothy Irwin Noel January 2017 (has links)
No description available.
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| 1305 |
A synthetic approach to (+)-AcutiphycinMaczka, Maciej January 2017 (has links)
(+)-Acutiphycin appeared in the literature in 1984, when Moore and co-workers reported their discovery of this novel macrolide in extracts of the blue-green alga, Oscillatoria acutissima. Their biological evaluations of (+)-acutiphycin subsequently showed efficacy at combatting the growth of a human KB nasopharyngeal cancer cell line during in vitro screening. In addition, it demonstrated significant antineoplastic activity in vivo against murine Lewis lung carcinoma with a T/C of > 150, when administrated at doses of 50 mg/kg, which corresponds to a >50% life extension being conferred on these animals. Due to the significant pharmaceutical interest that exists in (+)-acutiphycin, and in an effort to provide a future clinical supply, there has been significant effort expended on developing a viable total synthesis of this molecule. In Chapter 1 of this thesis I will present synthetic approaches to (+)-acutiphycin published to date in the literature, while Chapter 2 will describe Hale’s approach to this complex molecule. Moreover, I will report the first successful application of O-directed double free radical hydrostannation reaction in the synthesis of natural products. Through an awareness of the highly complex mechanism of this reaction, and our introduction of a conformation-restraining acetal, to prevent stereocenter-compromising 1,5-H-atom abstraction reactions by vinyl radical intermediates, the two trisubstituted alkenes present in the C(7)-C(22) region of (+)-acutiphycin were constructed concurrently with high stereocontrol.
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| 1306 |
Clinical Pharmacological Aspects of DiazepamGamble, J. A. S. January 1975 (has links)
No description available.
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| 1307 |
Studies of the disposition, actions and excretion of beta-adrenoceptor blocking drugsRiddell, J. G. January 1979 (has links)
No description available.
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| 1308 |
Central haemodynamic and peripheral vascular effects of morphineSamuel, I. O. January 1977 (has links)
No description available.
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| 1309 |
Monoamine oxidase: some determinants of activity for substrates and inhibitorsWilliams, C. H. January 1972 (has links)
No description available.
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| 1310 |
Adrenergic beta-receptor stimulation and blockade in man and animalsKofi Ekue, J. M. January 1972 (has links)
No description available.
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