- About
-
The Global ETD Search service is a free service for researchers
to find electronic theses and dissertations. This service is
provided by the
Networked Digital Library of Theses and Dissertations.
Our metadata is collected from universities around the world. If you manage a university/consortium/country archive and want to be added, details can be found on the NDLTD website.
Search results
Showing 1591 to 1600 of 4832 (0.018 seconds)| 1591 |
Investigation of polymorphisms in human arylamine N-acetyltransferaseHickman, Dean January 1993 (has links)
No description available.
|
| 1592 |
Studies on human N-acetyltransferaseCoroneos, Erifili January 1992 (has links)
No description available.
|
| 1593 |
The preparation and properties of some bladder smooth muscle relaxantsSummers, Martin J. January 1996 (has links)
No description available.
|
| 1594 |
Studies on bacterial proline 4-hydroxylaseLawrence, Christopher C. January 1993 (has links)
No description available.
|
| 1595 |
An investigation into the long-term effects of experimental limbic epilepsy of exploratory behaviour of ratsNicholls, Briony Rachel January 1994 (has links)
No description available.
|
| 1596 |
Neural control of the urethra and the mechanisms underlying inhibitory transmission in smooth muscleBridgewater, Melissa January 1994 (has links)
No description available.
|
| 1597 |
Studies towards the total synthesis of aerocyanidinChen, Deqi January 1994 (has links)
No description available.
|
| 1598 |
Flow injection determination of drugs by enzyme inhibitionGhous, T. January 1995 (has links)
No description available.
|
| 1599 |
The pharmacology of nicotinic acetylcholine receptors in Heliothis virescens and Locusta migratoria neurones in vitroJackson, Charles E. P. January 1998 (has links)
No description available.
|
| 1600 |
Molecular pharmocology of cannabinoids and the novel cannabinoid receptor GPR55 in boneWhyte, Lauren Sarah January 2009 (has links)
Given the recent finding that the cannabinoid receptors CB<sub>1</sub> and CB<sub>2</sub> affect bone metabolism, we examined the role of GPR55 in bone biology. GPR55 was expressed in human and mouse osteoclasts and osteoblasts; expression was higher in human osteoclasts than in macrophage progenitors. Although the GPR55 agonists O-1602 and LPI inhibited mouse osteoclast formation <i>in vitro</i>, these ligands stimulated mouse and human osteoclast polarisation and resorption <i>in vitro</i> and caused activation of Rho and ERK1/2. These stimulatory effects on osteoclast function were attenuated in osteoclasts generated from GPR55<sup>-/-</sup> macrophages and by the GPR55 antagonist cannabidiol (CBD). Furthermore, treatment of mice with this non-psychoactive constituent of cannabis significantly reduced bone resorption <i>in vivo</i>. Consistent with the ability of GPR55 to suppress osteoclast formation but stimulate osteoclast function, histomorphometric and microcomputed tomographic analysis of the long bones from male GPR55<sup>-/-</sup> mice revealed increased numbers of morphologically-inactive osteoblasts, but a significant increase in the volume and thickness of trabecular bone and the presence of unresorbed cartilage. These data reveal a hitherto unrecognised role of GPR55 in bone physiology by regulating osteoclast number and function. In addition, this study also brings to light a newly identified effect of both the endogenous ligand, LPI , on osteoclasts and of the cannabis constituent, CBD, on osteoclasts and bone turnover <i>in vivo</i>. These results suggest that blocking GPR55 with small molecules similar to CBD may be beneficial in bone diseases associated with increased osteoclast activity such as osteoporosis.
|
Page generated in 0.023 seconds