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  • About
  • The Global ETD Search service is a free service for researchers to find electronic theses and dissertations. This service is provided by the Networked Digital Library of Theses and Dissertations.
    Our metadata is collected from universities around the world. If you manage a university/consortium/country archive and want to be added, details can be found on the NDLTD website.
1691

Anti-inflammatory drugs and some aspects of the function of white blood cells

Patel, Rajnikant January 1985 (has links)
No description available.
1692

Bioequivalence of sustained release theophylline formulations

Purkiss, Ronald January 1986 (has links)
The bioequivalence of sustained release theophylline formulations, marketed in the United Kingdom, has been investigated in relation to the co-administration of food in both single dose and steady state volunteer studies. The effect of food on pharmacokinetic parameters and their clinical relevance was researched. Experimentation using drug induced modification of gastric motility to ascertain the component influences of the rate of gastric emptying on the absorption of theophylline from sustained release formulations was conducted. Prolongation of time to maximum plasma theophylline concentration by food reported in the literature and its clinical importance was investigated in once daily compared with twice daily administration of sustained release theophylline formulations and smoking habit. The correlation between saliva and plasma theophylline concentrations as a means of developing a non-invasive sampling techniques was examined. Data obtained from in vitro dissolution studies was compared with in vivo results. This thesis has shown no significant differences occurred in the pharmacokinetic parameters measured between sustained release formulations available in the United Kingdom. The investigations into the influence of food on prolongation of time to maximum plasma theophylline concentration and other measured pharmacokinetic parameters demonstrated no important pharmacokinetic or clinical effects. Smoking adults taking sustained release theophylline formulations had similar drug clearances to those reported in the literature for smokers taking plain uncoated theophylline formulations.
1693

The isolation production and development of dermatologically active constituents in coal tar

Wrench, Rosanne January 1973 (has links)
No description available.
1694

High-performance liquid chromatography and pharmacokinetics of some antibiotics

Scott, David K. January 1981 (has links)
The principles of High Performance Liquid Chromatography (HPLC) and pharmacokinetics were applied to the use of several clinically-important drugs at the East Birmingham Hospital. Amongst these was gentamicin, which was investigated over a two-year period by a multi-disciplinary team. It was found that there was considerable intra- and inter-patient variation that had not previously been reported and the causes and consequences of such variation were considered. A detailed evaluation of available pharmacokinetic techniques was undertaken and 1- and 2-compartment models were optimised with regard to sampling procedures, analytical error and model-error. The implications for control of therapy are discussed and an improved sampling regime is proposed for routine usage. Similar techniques were applied to trimethoprim, assayed by HPLC, in patients with normal renal function and investigations were also commenced into the penetration of drug into peritoneal dialysate. Novel assay techniques were also developed for a range of drugs including 4-aminopyridine, chloramphenicol, metronidazole and a series of penicillins and cephalosporins. Stability studies on cysteamine, reaction-rate studies on creatinine-picrate and structure-activity relationships in HPLC of aminopyridines are also reported. Keywords HPLC, pharmacokinetics, gentamicin, 4-aminopyridine, peritoneal dialysis.
1695

The in-vitro sensitivity testing of beta-lactam antibiotic combinations

Turner, Philip J. January 1985 (has links)
No description available.
1696

A study on the modes of action of angiotensin on isolated smooth muscle preparations

Chong, E. K. S. January 1974 (has links)
No description available.
1697

The interaction of angiotensin II with other spasmogens on vascular smooth muscle

Moore, Alan F. January 1974 (has links)
No description available.
1698

Metabolism and handling of folates in the mammal especially man

Ratanasthien, Kwanchai January 1975 (has links)
No description available.
1699

Tumour-inhibitory triazenes: search for a chemical basis for their mode of action

Turnbull, Colin P. January 1976 (has links)
No description available.
1700

Investigations on new antitumour agents

Gate, Ernest N. January 1985 (has links)
No description available.

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