1691 |
Anti-inflammatory drugs and some aspects of the function of white blood cellsPatel, Rajnikant January 1985 (has links)
No description available.
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1692 |
Bioequivalence of sustained release theophylline formulationsPurkiss, Ronald January 1986 (has links)
The bioequivalence of sustained release theophylline formulations, marketed in the United Kingdom, has been investigated in relation to the co-administration of food in both single dose and steady state volunteer studies. The effect of food on pharmacokinetic parameters and their clinical relevance was researched. Experimentation using drug induced modification of gastric motility to ascertain the component influences of the rate of gastric emptying on the absorption of theophylline from sustained release formulations was conducted. Prolongation of time to maximum plasma theophylline concentration by food reported in the literature and its clinical importance was investigated in once daily compared with twice daily administration of sustained release theophylline formulations and smoking habit. The correlation between saliva and plasma theophylline concentrations as a means of developing a non-invasive sampling techniques was examined. Data obtained from in vitro dissolution studies was compared with in vivo results. This thesis has shown no significant differences occurred in the pharmacokinetic parameters measured between sustained release formulations available in the United Kingdom. The investigations into the influence of food on prolongation of time to maximum plasma theophylline concentration and other measured pharmacokinetic parameters demonstrated no important pharmacokinetic or clinical effects. Smoking adults taking sustained release theophylline formulations had similar drug clearances to those reported in the literature for smokers taking plain uncoated theophylline formulations.
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1693 |
The isolation production and development of dermatologically active constituents in coal tarWrench, Rosanne January 1973 (has links)
No description available.
|
1694 |
High-performance liquid chromatography and pharmacokinetics of some antibioticsScott, David K. January 1981 (has links)
The principles of High Performance Liquid Chromatography (HPLC) and pharmacokinetics were applied to the use of several clinically-important drugs at the East Birmingham Hospital. Amongst these was gentamicin, which was investigated over a two-year period by a multi-disciplinary team. It was found that there was considerable intra- and inter-patient variation that had not previously been reported and the causes and consequences of such variation were considered. A detailed evaluation of available pharmacokinetic techniques was undertaken and 1- and 2-compartment models were optimised with regard to sampling procedures, analytical error and model-error. The implications for control of therapy are discussed and an improved sampling regime is proposed for routine usage. Similar techniques were applied to trimethoprim, assayed by HPLC, in patients with normal renal function and investigations were also commenced into the penetration of drug into peritoneal dialysate. Novel assay techniques were also developed for a range of drugs including 4-aminopyridine, chloramphenicol, metronidazole and a series of penicillins and cephalosporins. Stability studies on cysteamine, reaction-rate studies on creatinine-picrate and structure-activity relationships in HPLC of aminopyridines are also reported. Keywords HPLC, pharmacokinetics, gentamicin, 4-aminopyridine, peritoneal dialysis.
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1695 |
The in-vitro sensitivity testing of beta-lactam antibiotic combinationsTurner, Philip J. January 1985 (has links)
No description available.
|
1696 |
A study on the modes of action of angiotensin on isolated smooth muscle preparationsChong, E. K. S. January 1974 (has links)
No description available.
|
1697 |
The interaction of angiotensin II with other spasmogens on vascular smooth muscleMoore, Alan F. January 1974 (has links)
No description available.
|
1698 |
Metabolism and handling of folates in the mammal especially manRatanasthien, Kwanchai January 1975 (has links)
No description available.
|
1699 |
Tumour-inhibitory triazenes: search for a chemical basis for their mode of actionTurnbull, Colin P. January 1976 (has links)
No description available.
|
1700 |
Investigations on new antitumour agentsGate, Ernest N. January 1985 (has links)
No description available.
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