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The Global ETD Search service is a free service for researchers
to find electronic theses and dissertations. This service is
provided by the
Networked Digital Library of Theses and Dissertations.
Our metadata is collected from universities around the world. If you manage a university/consortium/country archive and want to be added, details can be found on the NDLTD website.
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Showing 631 to 640 of 4832 (0.018 seconds)| 631 |
The novel testicular toxicity of a 5HT-1 receptor agonistPiner, J. A. January 1998 (has links)
The aims of the work presented in this Thesis were to establish the nature and mechanism of the testicular and epididymal toxicity in Charles River Wistar rats, at least 10 weeks of age, after administration of high dosages of GR403370D, a 5HT-1 receptor agonist that was under development by Glaxo Wellcome for the potential relief of migrainous headaches. Initial investigations used a detailed morphological examination of perfusion-fixed tissues which were confirmed and/or further characterised using image analysis. The testicular vasculature was implicated as the initial target, since a reduction in the cross-sectional area of the veins of the mediastinal venous plexus (MVP) was the earliest change found. Subsequent experiments found that arterial-venous anastomoses (AVAs) of the spermatic cord to be constricted or shut. These findings are consistent with the general pharmacological action of 5HT-1 receptor agonists, developed to act on the vasculature, specifically the AVAs of the carotid arterial bed. Changes in the testis and epididymis were considered to have occurred as a consequence of the effect on the testicular vasculature. Effects were evident at 12 to 48 hours post-dose and included increased testicular weight, an increase in the diameter of the seminferious tubules, distension of the rete testis, and an increase in vaculation of the cytoplasm of elongating spermatids. Furthermore, interstitial fluid volume and seminiferous tubular fluid production were reduced. Changes were seen later in the epididymis at 24 to 48 hours, and included an increase in the size of the lumen of the duct in the initial segment and caput regions with oedema of the interstitial space and a concurrent increase in weight of the epididymis. Testicular and epididymal changes were found to be fully reversible after sufficient time (up to 168 hours) was allowed. Further studies demonstrated that repeat administration of a toxic dosage resulted in more severe consequences.
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| 632 |
A pharmacological study of transmission in a sympathetic ganglionRay, C. January 1963 (has links)
No description available.
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| 633 |
The effects of chemical structure on the affinity of compounds for acetylcholine receptorsMustafa, M. G. January 1967 (has links)
No description available.
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| 634 |
A study of the antibacterial activity of some alcoholsAl-Zaidy, Hamed Majeed January 1975 (has links)
No description available.
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| 635 |
The pharmacology of some 1,2,3-benzotriazinesCull, Geraldine A. G. January 1972 (has links)
No description available.
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| 636 |
The processing and interpretation of National Health Service prescription dataGeddes, Gordon Lewis January 1977 (has links)
No description available.
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| 637 |
A study of antiarrhythmic neuromuscular blocking actions of 1,2,3,-benzotriazine derivativesKhan, Mohammad Tosif January 1973 (has links)
No description available.
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| 638 |
Investigation of the effect of phenylethanol on the inactivation of P. aeruginosa by chemical agentsMcBride, Reginald J. January 1973 (has links)
No description available.
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| 639 |
Synthesis and degradation of triazines of potential medicinal importanceStevens, Howard Norman Ernest January 1970 (has links)
No description available.
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| 640 |
Synthetic routes to novel tetracyclic compounds containing the indazole nucleusAlkhamees, Hamad Abdalaziz January 1985 (has links)
No description available.
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