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The Global ETD Search service is a free service for researchers
to find electronic theses and dissertations. This service is
provided by the
Networked Digital Library of Theses and Dissertations.
Our metadata is collected from universities around the world. If you manage a university/consortium/country archive and want to be added, details can be found on the NDLTD website.
Search results
Showing 61 to 70 of 545 (0.014 seconds)| 61 |
S-nitrosothiols, nitric oxide and platelet and vascular dysfunction in cirrhosisOllosson, Richard Charles January 2008 (has links)
Elevated plasma concentration of the known platelet inhibiting species S-nitrosothiols are correlated for the first time to platelet dysfunction in the bile duct ligated (BDL) cirrhotic rat. Further, a BDL model of cirrhosis has been established and characterised in a strain of analbuminaemic rats and a correlation made between a protection against S-nitrosothiol formation conferred by analbuminaemia and less dysfunction in platelet aggregation following induction of endotoxaemia and cirrhosis. Also, it has been demonstrated that the majority of signal previously attributed to S-nitrosothiols during chemiluminescent detection in the plasma from endotoxaemic cirrhotic rats is mercury stable and is therefore attributed to N-nitrosamine formation. The identity of the mercury stable fraction of NO carrying species in plasma has been partially characterised and found to be carried either on albumin or on an albumin associated molecule. It has also been established that when the conjectured N-nitrosamine is synthesised in vitro and incubated with platelets, it is found to have an inhibitory effect on platelet aggregation similar to that found from S-nitrosothiols. Hypo-reactivity of isolated aortic rings to vasoconstrictors has also been confirmed in the rat model of BDL cirrhosis. However, the injection of cirrhotic rats with lipoic acid (a thiol antioxidant shown to ameliorate the development of the hyperdynamic circulation in the bile duct ligated rat), had no effect on the reactivity of isolated aortic rings as was initially hypothesised. Finally, an adaptation of the Ellman's reaction for analysis of total reduced thiol concentration in plasma was validated and used to assess plasma reduced thiol concentration in cirrhotic rats. It was found that chronic, 25 day bile duct ligation results in a drop in free thiol concentration in the plasma of 75% over sham operated rats.
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The role of peroxisome proliferator activated receptor agonists in Cardiovascular diseaseHughes, Robert Ian January 2008 (has links)
No description available.
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Hair analysis as a diagnostic tool in post-mortem toxicologyCordero, Rosa Elena January 2009 (has links)
No description available.
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In Vitro Investigations of the Structure Metabolism Relationships of Mono-Substituted Benzoic AcidsBailey, Christopher John January 2009 (has links)
No description available.
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Studies on the Molecular Basis of Methyl Eugenol CarcinogenicityEllis, James Keith January 2008 (has links)
No description available.
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Molecular and pathophysiological mechanism of cutaneous hypersensitivity and the effect of topical agentsRoberts, Katherine Mary January 2009 (has links)
No description available.
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Evidence-based assessment of the safety of topical corticosteroids in pregnancyChi, Ching-Chi January 2009 (has links)
No description available.
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An investigation into the effects of aneugens in the mouse lymphoma assay - a genetic toxicological assay for mamaalian gene mutationKidd, Darren January 2010 (has links)
No description available.
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Gastrointestinal inflammation : non steroidal anti-inflammatory drugs and inflammatory bowel disease; novel evaluation and treatment of diseaseMaiden, Laurence Peter January 2008 (has links)
No description available.
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An investigation of whether it would be possible for CoCr orthopaedic wear debris to damage a foetus after exposure through a placental cell barrierSood, Aman January 2009 (has links)
No description available.
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