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The Global ETD Search service is a free service for researchers
to find electronic theses and dissertations. This service is
provided by the
Networked Digital Library of Theses and Dissertations.
Our metadata is collected from universities around the world. If you manage a university/consortium/country archive and want to be added, details can be found on the NDLTD website.
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Investigation of type-I interferon regulated gene expression in murine dendritic cellsBalman, Elizabeth Philippa January 2006 (has links)
Dendritic cells (DCs) provide a vital link between the innate and adaptive immune systems, allowing for detection of invading pathogens and the rapid initiation of an appropriate response. Until recently, research on type-I interferons (IFN-I) has focused on their function as viral inhibitors. However, it is now evident that IFN-I also has multiple roles in immune regulation, including the alteration of DC function. IFN-I has been shown to enhance T and B cell responses in vivo through stimulation of DCs, but the mechanisms by which IFN-I acts on DCs to produce these effects are unclear. We have investigated how gene expression is altered in IFN-I treated DCs, with the aim of identifying IFN induced genes which enhance the ability of DCs to initiate and sustain an effective immune response. Murine splenic CD1 lc+ DCs or bone marrow-derived DCs were isolated and cultured either alone or in the presence of IFN-I, and two techniques were employed for discovery of differentially expressed genes: representational difference analysis (RDA) and microarray analysis. We identified IFN-I induced genes involved in diverse aspects of cell function, including transcription factors, signaling molecules, co-stimulatory molecules, cytokines and chemokines. For further study, we selected genes which encode putative cell surface proteins or which share homology with proteins involved in adaptive immune functions. Investigation of a putative chemoattractant receptor, Gpr33, showed that expression of this molecule was upregulated in DCs in response to IFN-I both in vitro and in vivo. We attempted to generate antibodies against Gpr33 and have studied mRNA expression by real time PCR. Gpr33 mRNA expression was shown to be upregulated by IFN-I in all splenic DC subsets, but was expressed in the CD8+ subset at levels more than 40 fold higher than the CD4+ subset, indicating that it may specifically be involved in the migration of this subset.
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Production and function of type 1 interferons in the immune responseGermain, Conrad Andrew January 2005 (has links)
No description available.
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The type 1 insulin-like growth factor receptor (IGF1R) as anti-cancer treatment targetRiedemann, Johann January 2006 (has links)
No description available.
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The role of tapasin in MHC class 1 antigen presentationWilliams, Anthony Peter January 2004 (has links)
No description available.
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Computational modelling of cell signalling pathway dynamicsHorton, Caroline Alison January 2006 (has links)
No description available.
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Studies of the murine and human immune response to the tumour-associated antigen MUC1Plunkett, Timothy Andrew January 2003 (has links)
No description available.
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Function of chicken tapasin in MHC class I antigen presentationHateren, Andrew James van January 2006 (has links)
No description available.
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The expression of recombinant IgE receptors in 'Escherichia coli' and the identification of IgE reactive proteins from Dermatphagocides pteronyssinus', 'Schistosoma mansoni' and 'Callosobruchus maculatusUpton, Anthony January 2004 (has links)
No description available.
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The role of SP-D and C1q in apoptotic recognitionRoake, Wendy January 2003 (has links)
No description available.
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Investigations into the biological functions of the CC chemokine CCL5/RANTESChaffey, Benjamin T. January 2004 (has links)
No description available.
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