- About
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The Global ETD Search service is a free service for researchers
to find electronic theses and dissertations. This service is
provided by the
Networked Digital Library of Theses and Dissertations.
Our metadata is collected from universities around the world. If you manage a university/consortium/country archive and want to be added, details can be found on the NDLTD website.
Search results
Showing 1 to 10 of 41 (0.009 seconds)| 1 |
The molecular pathology of bone morphogenetic protein signalling in the normal and pulmonary hypertensive lungSouthwood, Mark Richard January 2008 (has links)
Pulmonary arterial hypertension (PAH) is characterised by a fixed elevation in pulmonary artery pressure in response to intraluminal vascular cell proliferations. Bone morphogenetic protein (BMP) signalling exerts powerful mitogenic responses in vascular cells although the complete mechanisms by which dysfunctional BMP and Smad signalling contribute to vascular remodelling observed in PAH remain unloiown. Mutations in the BMPR2 gene, encoding the type II BMP receptor (BMPR-II), underlie many cases of familial PAH. Here, the BMP and Smad signalling pathway are characterised and reduced vascular BMP and Smad expression identified in human PAH lung, presumably leading to a loss of growth control over puhnonary vascular cells. To evaluate the impact of SiBMPR2 mutation during vasculogenesis or in adult PAH, gene silencmg for BMPR2 and adenoviral transfection of mutant receptor construct were used to disrupt Smad signalling and were found to interrupt endothelial cell proliferation and migration in vitro.
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Regulators of renal sodium reabsorption and essential hypertension : candidate gene analysis of the WNK1 and WNK4 genesNewhouse, Stephen Jeffrey January 2006 (has links)
No description available.
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Tetrahydrobioterin and nitric oxide metabolismLam, Amanda Ay Jia January 2004 (has links)
No description available.
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Development of bronchial and vascular smooth muscle and the effects of pulmonary hypertensionSchindler, Margrid Brigitte January 2004 (has links)
No description available.
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Arterial stiffness in hypertensionStewart, Andrew David January 2005 (has links)
No description available.
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Transepithelial sodium transport and essential hypertensionIreson, Nicola Jayne January 2003 (has links)
No description available.
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Molecular characterisation of the aminopeptidase P gene 5' regulatory regionJones, Amy L. January 2006 (has links)
No description available.
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The effect of genetic manipulation of brain angiotensin II on the kidneyDent, Paul Christopher January 2003 (has links)
No description available.
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Arterial stiffness in health and diseaseAlem, Manal Mohammed January 2005 (has links)
No description available.
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Molecular and clinical studies of corticosteroid biosynthesis and regulation in hypertensionFreel, Ellen Marie January 2006 (has links)
No description available.
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