- About
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The Global ETD Search service is a free service for researchers
to find electronic theses and dissertations. This service is
provided by the
Networked Digital Library of Theses and Dissertations.
Our metadata is collected from universities around the world. If you manage a university/consortium/country archive and want to be added, details can be found on the NDLTD website.
Search results
Showing 281 to 290 of 957 (0.008 seconds)| 281 |
The effect of bacterial and host proteinases on defence molecules in the cystic fibrosis respiratory tractEinarsson, Gisli Geir January 2009 (has links)
No description available.
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| 282 |
Cardiac and Neurohumoral Abnormalities in Systemic SclerosisDonnelly, R. January 2010 (has links)
No description available.
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| 283 |
Investigating the expression and secretion of matrix metalloproteinases by inflammatory and parenchymal lung cells in acute lung injuryEdwards, A. J. P. January 2012 (has links)
No description available.
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| 284 |
Impact of different CFTR Mutations on Airway Epithelium FunctionWilliams, M. T. S. January 2010 (has links)
No description available.
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| 285 |
Human respiratory syncytial virus F protein-induced immunosuppression : structures, mechanisms and novel vaccinesQuinn, Caroline Frances January 2013 (has links)
Respiratory syncytial virus (RSV) is a major cause of morbidity and mortality in humans. It repeatedly infects throughout life, suggesting induction of poor memory immune responses. The RSV F protein is a highly conserved antigen that was studied extensively as a vaccine both in animal models and clinical trials but has so far failed in humans. Interestingly. evidence suggested that RSV F blocks proliferation of PHA-stimulated human PBMCs in a contact-dependent and species-specific manner. Specifically, HRSV F preferentially inhibited human PBLs, while bovine RSV F preferentially inhibited bovine PBLs. We aligned multiple strains of human and bovine RSV to identify 8 species-specific residues. We hypothesized that replacing the 8 HRSV F residues with their bovine counterparts would not alter the antigenic or immunogenic structure of HRSV F, while removing the capacity of HRSV F to block human PBL proliferation. Using site-directed mutagenesis, we generated a recombinant HRSV F protein (rHRSV Fmut8) comprising the 8 bovine residues. rHRSV Fmut8 was shown to retain reactivity when tested with a panel of RSV F-specific MAbs, confirming that the antigenic structure was preserved. We subsequently generated and characterised a recombinant Sendai virus efficiently expressing our mutated HRSV F (rSeV/RSV Fmut8), found to be functional and antigenically intact. S.eV (mwine PIVI) was chosen as a vector, as it is immunogenic but non-pathogenic in humans, has vaccine potential against human parainfluenza virus type I (HPrv 1) and can be easily manipulated by reverse genetics. Following intra-nasal administration to BALB/c mice, rSeV/RSV Fmut8 induced protective immunity against RSV challenge. Human PBMC proliferation block experiments revealed that HRSV efficiently blocks inhibition, in which RSV F plays a role. If confirmed, abrogation of the human PBL proliferation block combined with its protective efficacy in vivo, suggests that rSeV/RSV Fmut8 will constitute a very interesting and novel RSV vaccine candidate.
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| 286 |
A comprehensive assessment of funtional outcomes and their impact on the quality of life in surgically treated oral and oropharyngeal cancer patientsDwivedi, Raghav Chandra January 2010 (has links)
No description available.
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| 287 |
Clinical trials to investigate the effect of breathing exercises on asthma controlCooper, Susan Elizabeth January 2010 (has links)
No description available.
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| 288 |
Studies into mucin and its regulation in pathogenesis of otitis media with effusionGuo, Li January 2009 (has links)
No description available.
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| 289 |
Consequences of mild sensorineural hearing loss for listening and learning in childrenMillward, Kerri E. January 2009 (has links)
No description available.
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| 290 |
The role of TNFa and IFNy on CXCL10 regulation and beta-2 agonist inhibition in human airway smooth muscle cellsJindarat, Sarawut January 2009 (has links)
No description available.
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