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The Global ETD Search service is a free service for researchers
to find electronic theses and dissertations. This service is
provided by the
Networked Digital Library of Theses and Dissertations.
Our metadata is collected from universities around the world. If you manage a university/consortium/country archive and want to be added, details can be found on the NDLTD website.
Search results
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Airway clearance in cystic fibrosisMcIlwaine, Patricia Margaret January 2014 (has links)
This thesis overviews and highlights a body of work performed at the BC Children's Hospital, Vancouver, Canada between 1986 and 2013, and involving travel to Belgium, Denmark and the United Kingdom. It is based on five articles published by McIlwaine on research and development in the use of various airway clearance techniques for the treatment of cystic fibrosis, namely: Autogenic Drainage; Positive Expiratory Pressure; Oscillating Positive Expiratory Pressure; and High Frequency Chest Wall Oscillation. The thesis comprises of seven chapters, including the introduction. Chapter 2 presents the physiological evidence and theories to support each technique. Chapter 3 describes various types of airway clearance studies based on the published studies submitted by McIlwaine and discusses barriers and challenges related to each study design. A clinical research pathway for future airway clearance studies is proposed. Chapter 4 examines the use of outcome measures for each stage of the pathway. Chapter 5 is based on the most recent published paper by McIlwaine, and offers an overview on how to optimise designing a multi-centre clinical airway clearance study, identifying challenges and barriers to performing such a study. The work presented in this thesis has contributed to research by furthering an understanding of the physiology upon which various airway clearance techniques are based, as well as providing guidance on the use of appropriate outcome measures. The published papers underlying the thesis have validated the airway clearance techniques of Autogenic Drainage and positive Expiratory Pressure and have in-validated the use of Oscillating PEP using Flutter and High Frequency Chest Wall Oscillation, in the treatment of cystic fibrosis. Outcomes of this work have lead to a change in clinical practice, in Europe and N. America, and have had a direct and positive effect in decreasing the burden of care in people living with cystic fibrosis.
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Parental dysphoria following the diagnosis of cystic fibrosis : testing a systemic modelGlasscoe, Claire Anita January 2003 (has links)
No description available.
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Molecular analysis of respiratory infections in cystic fibrosis patientsRogers, Geraint Berian January 2004 (has links)
No description available.
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Novel anti-inflammatory and mucolytic effects of heparin in vitroBroughton-Head, Victoria Jane January 2005 (has links)
No description available.
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Airway inflammation and remodelling in cystic fibrosisHilliard, Thomas Norman January 2006 (has links)
No description available.
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Developing vectors for cystic fibrosis gene therapy : improving the longevity and tissue specificity of gene expressionBergau, Anna January 2005 (has links)
No description available.
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Magnetofection and sonoporation to enhance non-viral gene transfer to airway epitheliumXenariou, Stefania January 2006 (has links)
No description available.
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A study to measure adherence with inhaled therapies in patients with cystic fibrosis and to assess the potential value of psychological interventions aimed at addressing barriers to good complianceQuinn, Joanne Elizabeth January 2004 (has links)
No description available.
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Molecular and functional investigations of the calcium activated chloride channel in cystic fibrosis pancreatic duct cellsMarsey, Laura Louise January 2007 (has links)
No description available.
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Linking lung inflammation and chloride secretion in cystic fibrosisClayton, Andrew Alan January 2005 (has links)
No description available.
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