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The Global ETD Search service is a free service for researchers
to find electronic theses and dissertations. This service is
provided by the
Networked Digital Library of Theses and Dissertations.
Our metadata is collected from universities around the world. If you manage a university/consortium/country archive and want to be added, details can be found on the NDLTD website.
Search results
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A study of endothelial chemokine binding sites in the rheumatoid synoviumGardner, Lucy Elizabeth January 2005 (has links)
Rheumatoid arthritis (RA) is a chronic systemic inflammatory disease resulting in the inflammation of the synovium. Chemokines play a fundamental role in RA which occurs either through their specific receptors or through binding to the Duffy antigen receptor for chemokines (DARC) or to glycosaminoglycans (GAGs). DARC and GAGs are present on the endothelium of postcapillary venules which makes them ideally situated for being involved in the endothelial transcytosis and presentation of chemokines to leucocytes within the circulation. DARC has been shown to be involved in inflammation. This study has shown that DARC expression is present on the endothelium in synovia of patients with early and longstanding RA Through the use of radioligand binding assays on erythrocytes and in situ binding studies in RA and non-RA synovia, it has been revealed that DARC has some selectivity in which chemokines it binds. It bound to 60% of inflammatory chemokines examined and it did not bind the constitutive chemokines, with the exception of CCL17. The binding profile on endothelial cells was also found to be the same as that on the erythrocytes. DARC was also found not to bind to ELR negative CXC chemokines with the exception ofCXCLl1. It was observed that there was a decrease in the presence of heparan sulphate on the endothelium of venules in RA synovia. It was possible to compete off CXCL8 binding to heparan sulphate using the low molecular weight heparin, Monoparin. Different sized heparin saccharides could also reduce the binding ofCXCL8, with the most effective being the 24-mer.
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Role of nitrergic and prostanoid systems in joint inflammationDay, Suzanne Mary January 2003 (has links)
No description available.
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Functional applications of CD44-splice variant expression in rheumatoid arthritisWibulwas, Auragan January 2004 (has links)
No description available.
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A new method of modelling macromolecular interactions applied to antibody self-association and receptor interactionsGrimmett, Jake Oliver Francis January 2003 (has links)
No description available.
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Genetic determinants of susceptibility and severity in rheumatoid arthritisSteer, Sophia Elizabeth January 2005 (has links)
No description available.
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Quantitative radiographic assessment of cancellous bone organization in the hands of patients with rheumatoid arthritisGoldie, Luisa Isabel Disini January 2002 (has links)
No description available.
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An examination of the suppression of IL-10 suppression of TNF in myeloid cellsRicchetti, Giuseppe Antonio January 2006 (has links)
No description available.
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The mechanism of tendon degradation by tenosynovium in rheumatoid arthritisJain, Abhilash January 2004 (has links)
No description available.
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Mechanisms of MHC-class II restricted presentation of aggrecan in an animal model of rheumatoid arthritisLowes, Katie January 2005 (has links)
No description available.
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Mechanisms & management of tumour necrosis factor-blockade non-response in patients with rheumatoid arthritisBuch, Maya Hema January 2007 (has links)
No description available.
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