- About
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The Global ETD Search service is a free service for researchers
to find electronic theses and dissertations. This service is
provided by the
Networked Digital Library of Theses and Dissertations.
Our metadata is collected from universities around the world. If you manage a university/consortium/country archive and want to be added, details can be found on the NDLTD website.
Search results
Showing 591 to 600 of 2058 (0.018 seconds)| 591 |
Poliomyelitis, with particular reference to the 1950 epidemic in Aberdeen city and countyLaing, B. C. January 1952 (has links)
No description available.
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| 592 |
A laboratory and clinical study of typhoid fever, with particular reference to the use of fibrinolytic enzymes in bacteriological diagnosisWatson, K. C. January 1955 (has links)
No description available.
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| 593 |
A study of staphylococcal resistance to penicillinForbes, G. B. January 1951 (has links)
No description available.
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| 594 |
Host-parasite interactions : cellular immune responses and modulation by cyclosporin AMcLauchlan, P. E. January 1998 (has links)
The role of cyclosporin A (CsA) as an immunomodulatory and antiparasitic drug was examined. The immune responses in various host:parasite relationships were examined giving an insight into the complicated nature of this relationship. In addition, analogues of CsA were screened to investigate the antiparasitic mode of action of cyclosporins. Expulsion of intestinal parasites has been proposed to involve the cellular immune response but its precise role is unknown. In CBA/ca mice infected with <I>Hymenolepsis diminuta</I>, peak intestinal mucosal mast cell (IMMC) numbers and release of mast cell protease (mMCP-I) correlated with parasite expulsion. Immunosuppression by cyclosporin A (CsA) treatment abrogated the response and allowed <I>H. diminuta</I> to survive to maturity. In contrast, <I>H. microstroma</I> survived long-term in MF1 mice, despite a significant and sustained IMMC response and mMCP-I release. It is proposed that the protease has different roles in these hymenolepid infections. Goblet cell proliferation did not occur in either infection. Adult <I>Schistosoma mansoni</I> are less susceptible to CsA than juveniles and reduced drug efficacy correlates with the onset of egg deposition and pathology in the liver of the host. This may alter metabolism of CsA and prevent the production of an active metabolite. CsA and metabolites were identified in mice tissues using reverse phase HPLC but problems with background peaks and low drug recovery prevented examination of the metabolite profile. CsA is antiparasitic against a range of protozoa and helminths but its mode of action is unknown. One possibility is that it involves the binding protein, cyclphilin (CyP). Three analogues of CsA, B-5-49, CsH and CsA-acetate (CsA-A) were screened against <I>H. microstroma in vitro</I>, which is susceptible to CsA. All analogues induced drug damage comparable to CsA. However, only B-5-49 bound to <I>H. microstroma </I>cytosolic CyP, suggesting that CyP is not necessary for the antiparasitic action of cyclosporins. Schistosomes suppress the activity of the internal defence system in their host in order to ensure their survival.
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| 595 |
Poliomyelitis in South Africa with special reference to an outbreak in East London indicating the changing pattern of the disease in South AfricaSinclair-Smith, D. January 1958 (has links)
No description available.
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| 596 |
Some studies on the control of pyogenic staphylococci in hospitalsSmylie, H. G. January 1960 (has links)
No description available.
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| 597 |
Studies on mycobacterium tuberculosis transcriptional regulators involved in intracellular infectionEstorninho, Megan January 2010 (has links)
No description available.
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| 598 |
Investigating single cell growth dynamics of mycrobacteria with microfluidicsGolchin, Solmaz Ariana January 2011 (has links)
No description available.
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| 599 |
A study of the bacteria of the nasopharynx of healthy dogs, with some observations concerning their significanceSmith, John Earle January 1960 (has links)
No description available.
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| 600 |
Neuropharmacology of epileptiform and other synaptic potentials in rat neocortical slicesAram, Julia Anne January 1988 (has links)
No description available.
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