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The Global ETD Search service is a free service for researchers
to find electronic theses and dissertations. This service is
provided by the
Networked Digital Library of Theses and Dissertations.
Our metadata is collected from universities around the world. If you manage a university/consortium/country archive and want to be added, details can be found on the NDLTD website.
Search results
Showing 1 to 10 of 31 (0.01 seconds)| 1 |
Investigation of a sulphur mobilisation gene in Plasmodium falciparumBurns, William Richard January 2006 (has links)
Plasmodium falciparum is the principal causative agent of malaria. Cells of the organism harbour a plastid organelle that constitutes a potential drug target. Metabolic functions associated with the plastid include the synthesis of isoprenoids, fatty acids and haem. Iron-sulphur Fe-Sl clusters may also be assembled in the organelle. Two systems (ISC and SUF) are implicated in biological Fe-S cluster assembly in malaria. The ISC system probably functions in the mitochondrion while the SUF system operates in the plastid. The objective of this project was to investigate a gene in P. falciparum with marked homology to SufS, a cysteine desulphurase (EC 2.8.1.7) of the SUF system in Escherichia coli and Arabidopsis thaliana. P. falciparum SufS (PfSufS) is encoded on chromosome seven of the nuclear genome but is predicted to be trafficked to the plastid organelle. A number of techniques have been applied to investigate the function of PfSufS in this thesis. Following a general introduction in chapter 1, subsequent chapters describe progress with this work. In chapter 2, account is given of investigations into the properties of PfSufS using a combination of bioinformatic and in vitro techniques. Progress towards defining the intracellular targeting of PfSufS by transfection and immunolocalisation is described in chapter 3. Development of a simple colorimetric cysteine desulphurase assay is reported in chapter 4. Finally, attempts have been made to produce recombinant PfSufS for enzymological studies (chapter 5).
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Range, quality and costs of antimalarial drugs available in the retail sector in KenyaAmin, Abdinasir Abass January 2005 (has links)
No description available.
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New directions inartemisinin-based combination therapy : chemotherapeutic studies of multi-drug resistant falciparum malariaAshley, Elizabeth January 2007 (has links)
No description available.
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Design synthesis and evaluation of novel DNA targeted antimalarial and tumouricidal endoperoxidesJones, Michael January 2007 (has links)
No description available.
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The synthesis and metabolism of novel 4-aminoquinoline antimalarialsShone, Alison Emily January 2007 (has links)
No description available.
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The molecular toxicology of Cryptolepis sanguinolenta, a West African anti-malarial herbal medicineAnsah, Charles January 2004 (has links)
No description available.
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Design and synthesis of new dihydroorotate dehydrogenase inhibitors as potential antimalarialsDavies, Matthew January 2007 (has links)
No description available.
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A randomised controlled trial of atovaquone/proguanil versus sulfadoxine/pyrimethamine, with or without folic acid supplementation in the treatment of severe malarial anaemiaMulenga, Modest January 2003 (has links)
No description available.
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The fine specificities of natural IgG responses to Plasmodium falciparum MSP1â‚₉, a malaria vaccine candidateOkech, Brenda Apio January 2006 (has links)
No description available.
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Seasonal preventive treatment with artesunate and sulfadoxine pyrimethamine prevents malaria in Senegalese childrenCisse, Badara January 2005 (has links)
No description available.
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