- About
-
The Global ETD Search service is a free service for researchers
to find electronic theses and dissertations. This service is
provided by the
Networked Digital Library of Theses and Dissertations.
Our metadata is collected from universities around the world. If you manage a university/consortium/country archive and want to be added, details can be found on the NDLTD website.
Search results
Showing 1 to 10 of 14 (0.007 seconds)| 1 |
The design and synthesis of a new lead against tuberculosisAl-Balas, Qosay Ali January 2008 (has links)
It is estimated that one-third of the world's population has been exposed to the tuberculosis bacterium; killing eight million every year. Since the 1960s there have been no new drugs marketed, which is primarily due to the Mycobacterium tuberculosis bacilli having a complex cell wall structure, intracellular existence in the host and its ability to stay dormant for extended periods. The continual increase in drug resistance and the lack of new chemotherapeutic agents means the search for a new antimycobacterial agent is of great importance. Our molecular modelling studies identified a thiazole-based scaffold as a potential candidate for optimization, which has a feasible synthetic route and is amenable to library generation to effectively explore local chemical space. Biological screening of the prepared compounds resulted in the identification of some compounds expressing excellent activity against M. tuberculosis with no observed toxicity. The most active compounds will be tested in vivo in mouse models infected with the pathogenic bacilli in order to perform further lead optimization to more drug-like compounds.
|
| 2 |
Synthesis of pegylated calixarenes towards new tuberculosis therapiesLoiseau, Francois Alexandre January 2004 (has links)
No description available.
|
| 3 |
Anti-mycobacterial agents based on thiolactomycinSenior, Suzanne J. January 2002 (has links)
No description available.
|
| 4 |
Design and synthesis of novel bacterial enzyme inhibitors as potential antituberculosis agentsAgarwal, Anil Kumar January 2007 (has links)
No description available.
|
| 5 |
Biochemical characterisation of the mycolyltransferase antigen 85 complex and transhydrogenase PntAA from Mycobacterium tuberculosisWilson, Rosalind Anne January 2005 (has links)
No description available.
|
| 6 |
Mechanistic studies of novel anti-tuberculosis targetsErrey, James C. January 2003 (has links)
No description available.
|
| 7 |
The development of novel quinols as anti-tubercular agentsShah, Manish Bipin January 2006 (has links)
No description available.
|
| 8 |
The genetics of autosomal dominant polycystic kidney disease in the Cy/+ ratBrown, Joanna H. January 2005 (has links)
No description available.
|
| 9 |
Endogenous role of arylamine N-acetyltransferase in mycobacteriaBhakta, Sanjib January 2005 (has links)
No description available.
|
| 10 |
Pharmacological determinants of anti-tuberculosis drug activityHartkoorn, Ruben Christiaan January 2006 (has links)
No description available.
|
Page generated in 0.0226 seconds