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The Global ETD Search service is a free service for researchers
to find electronic theses and dissertations. This service is
provided by the
Networked Digital Library of Theses and Dissertations.
Our metadata is collected from universities around the world. If you manage a university/consortium/country archive and want to be added, details can be found on the NDLTD website.
Search results
Showing 151 to 160 of 1298 (0.011 seconds)| 151 |
Investigating the role of peripheral serotonergic, purinergic and nitric oxide/cGMP pathways in the normal and pathological erectile process and the effect of Vardenafil on diabetic nephropathyLau, D. H. W. January 2012 (has links)
Serotonin (5-HT, 5-hydroxytrptamine), purinergic and nitric oxide (NO)/ cyclic guanosine monophosphate (cGMP) pathways have been implicated in human penile erection and erectile dysfunction (ED) and the later also involved in the pathogenesis of diabetic nephropathy (DN). The role and characterisation of the peripheral serotonergic and purinergic pathway in corpus cavernosal smooth muscle (CCSM) function was investigated. Electrical field stimulation of human and rabbit CCSM strips demonstrated the presence of neuronally-derived 5-HT acting on 5-HT(2A) receptors. Organ bath studies also showed that 5-HT caused CCSM contraction via 5-HT(1A), (1B), (2A) and (4) receptor subtypes, which was inhibited by doxazosin (an α-1 receptor antagonist known to have 5-HT inhibitory action). Immunohistochemistry and Western Blot analysis confirmed the presence of these 5-HT receptor subtypes in human CCSM. The effect of 5-HT and sodium nitroprusside (SNP; NO donor) on CCSM function from normal, diabetic and partial bladder outlet obstructed (PBOO) rabbit models were also assessed as these pathological models are associated with ED. There was no difference in 5-HT-induced CCSM contractions between the control and pathological models. In contrast, SNP-mediated relaxations were impaired in diabetic and PBOO rabbits. Vardenafil (phosphodiesterase type-5 inhibitor) improved the impaired CCSM relaxation in both models. Immunohistochemistry also identified the presence of purinergic P2Y6 receptors in human CCSM, which when activated induced tissue relaxation. Finally, the effect oral vardenafil treatment has on established renal impairment in diabetic rabbits was investigated. Vardenafil increased cGMP accumulation and improved renal function in DN. These findings suggests that targeting the peripheral serotonergic and purinergic pathways may be useful therapeutic options in treating ED. In addition, the use of vardenafil may be beneficial in the management of DN.
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Optical monitoring of radiofrequency tissue fusionFloume, Timmy January 2009 (has links)
No description available.
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CD4 T cell allorecognition pathways and the provision of help for generating CD8 T effector responses and alloantibody productionTaylor, Anna Louise January 2008 (has links)
No description available.
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| 154 |
Molecular manipulation of lymphocytes leading to allo-toleranceMoffatt, Susan Dianne January 1999 (has links)
No description available.
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Pathways of helper CD4 T cell allorecognition in humoral alloimmunityCole, Jennifer Louise January 2013 (has links)
No description available.
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| 156 |
Cerebrovascular reactivity after head injurySteiner, Luzius A. January 2003 (has links)
No description available.
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| 157 |
Application of solid-phase organic chemistry to the synthesis of PET radiopharmaceuticalsManu-Marfo, Mary January 2008 (has links)
No description available.
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| 158 |
The role of haem oxygenase-1 in the alloimmune responseMcDaid, James January 2004 (has links)
No description available.
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| 159 |
The role of donor CD4 T cells within solid organ transplants in chronic allograft vasculopathyWin, Thet Su January 2010 (has links)
No description available.
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| 160 |
Investigations into the pathophysiology of breast cancer-related lymphoedema (BCRL)Bennett Britton, Thomas Mark January 2008 (has links)
No description available.
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