251 |
The role of sprouty-2 in the malignant transformation of human fibroblasts by HRAS oncogeneLito, Piro. January 2006 (has links)
Thesis (Ph. D.)--Michigan State University. Dept. of Biochemistry and Molecular Biology, 2006. / Title from PDF t.p. (viewed on Nov. 17, 2008) Includes bibliographical references. Also issued in print.
|
252 |
The role of Id-1 on the proliferation, motility and mitotic regulation of prostate epithelial cellsDi, Kaijun. January 2007 (has links)
Thesis (Ph. D.)--University of Hong Kong, 2007. / Title proper from title frame. Also available in printed format.
|
253 |
Bmi-1 collaborates with H-ras to promote mammary epithelial cell transformation, tumorigenesis, and metastasisHoenerhoff, Mark James. January 2008 (has links)
Thesis (Ph.D.)--Michigan State University. Dept. of Pathobiology and Diagnostic Investigation, 2008. / Title from PDF t.p. (viewed on July 10, 2009) Includes bibliographical references (p. 157-174). Also issued in print.
|
254 |
Development and use of an adoptive transfer method for detecting radiation-induced bystander effects in vivoBlyth, Benjamin John, Unknown Date (has links)
Thesis (Ph.D.)--Flinders University, School of Medicine, Dept. of Haematology and Genetic Pathology. / Typescript bound. Includes bibliographical references: (leaves 248-282) Also available in an electronic version.
|
255 |
The role of the Akt-1 serine/threonine kinase in mammary gland development and tumorigenesis /Hutchinson, John N. G. Muller, William J. January 2003 (has links)
Thesis (Ph.D.)--McMaster University, 2004. / Advisor: William J. Muller. Includes bibliographical references (p. 145-186). Also available online.
|
256 |
UVB-induced inflammation and carcinogenesis in immunosuppressed miceHatton, Jennifer Leigh, January 2005 (has links)
Thesis (Ph. D.)--Ohio State University, 2005. / Title from first page of PDF file. Document formatted into pages; contains xix, 189 p. ; also includes graphics. Includes bibliographical references (p. 175-189). Available online via OhioLINK's ETD Center.
|
257 |
Proteomic and biochemical analyses of metal ion-induced carcinogenesis, apoptosis and apoptotic resistance in cultured rat lung epithelial cellsLau, Tao-yin. January 2005 (has links)
Thesis (Ph. D.)--University of Hong Kong, 2005. / Title proper from title frame. Also available in printed format.
|
258 |
EFA6A/ARF6 signaling and functions in glioblastoma carcinogenesis /Li, Ming, January 2006 (has links)
Thesis (Ph. D.)--University of Hong Kong, 2006. / Also available online.
|
259 |
The role of the transcription factor slug in the cutaneous response to ultraviolet radiation exposureNewkirk, Kimberly Michelle, January 2007 (has links)
Thesis (Ph. D.)--Ohio State University, 2007. / Title from first page of PDF file. Includes bibliographical references (p. 169-186).
|
260 |
Efeitos da capsaicina na etapa de promoção/progressão da carcinogênese química de colón em ratosTablas, Mariana Baptista. January 2018 (has links)
Orientador: Luís Fernando Barbisan / Resumo: A capsaicina (8-metil-N-vanilil-trans-6-nonamida) é uma substância alcaloide de natureza lipofílica, responsável pela pungência de pimentas e pimentões. Apresenta propriedades anti-inflamatória, antimicrobiana e antioxidante bem descritas na literatura científica. Assim, este projeto teve como objetivo investigar se a capsaicina apresenta efeito quimioprotetor quando administrada na etapa de promoção/progressão da carcinogênese de cólon induzida pela 1,2-dimetilhidrazina (DMH). Ratos Wistar machos foram alocados em seis grupos experimentais com 10 a 15 animais cada. Os animais dos grupos 1-3 receberam quatro injeções subcutâneas (s.c) do carcinógeno DMH (40mg/kg, duas doses/semana) e os animais do grupo 4-6 receberam quatro injeções s.c de solução de EDTA .Os grupos 2 e 4 receberam por gavagem 5mg/kg p.c e os grupos 3 e 5 receberam 50mg/kg p.c de capsaicina diluída em óleo de milho até o final da 24ª semana do experimento. Após a eutanásia dos animais, os cólons distal, medial e proximal foram corados com azul de metileno a 2% para detecção de focos de criptas aberrantes (FCA). Após a análise de FCAs, os cólons foram processados para análise histológica e classificação de tumores. As amostras congeladas foram utilizadas para análise de expressão de gênica pela técnica Taqman® Low Density Array (TLDA). Os níveis séricos de ALT (p=0,346) e creatinina (p=0,854) foram semelhantes entre os grupos, mostrando que as doses de capsaicina utilizadas não apresentaram ação citotóxica par... (Resumo completo, clicar acesso eletrônico abaixo) / Abstract: Capsaicin (8-Methyl-N-vanillyl-(trans)-6-nonenamide) is a lipophilic alkaloid, responsible for the pungency in pepper. Its antiinflamatory, antimicrobial and antioxidant properties are well described in the scientific literature. Thus, the objective of this study was to investigate whether capsaicin exerts a chemoprotective effect when administered during 1,2-dimethylhydrazine (DMH)-induced colon carcinogenesis promotion/progression in rates. Male Wistar rats were allocated into six groups of 10-15 animals each. Groups 1-3 received 4 subcutaneous injections of DMH (40 mg/kg bw, 2 doses/week), while groups 4-6 received EDTA solution (DMH vehicle, 2 doses/week), followed by intragastric 5mg/kg bw capsaicin diluted in corn oil (G2, G4) or 50mg/kg bw (G3, G5) for 24 weeks (3 doses/week). After sacrifice, blood samples were drawn by heart puncture for the assessment of serum alanine aminotransferase (ALT) and creatinine levels, and the colon was removed. A segment of distal colon and colon tumor samples were frozen in liquid nitrogen at -80ºC. Distal, medial and proximal colon samples were stained with 2% methylene blue for the detection of aberrant crypt foci (ACF).After ACF analysis, colon tumors were processed for histological analysis and tumor classification. The frozen samples were used for the analysis of gene expression by Taqman® Low Density Array (TLDA). Serum ALT (p=0.346) and creatinine (p=0.854) levels were similar among groups, indicating that the capsaicin doses use... (Complete abstract click electronic access below) / Doutor
|
Page generated in 0.0707 seconds