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The Global ETD Search service is a free service for researchers
to find electronic theses and dissertations. This service is
provided by the
Networked Digital Library of Theses and Dissertations.
Our metadata is collected from universities around the world. If you manage a university/consortium/country archive and want to be added, details can be found on the NDLTD website.
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Utvärdering av felmeddelande i eMM Software Version 00-06 till SysmexXE-5000Abrahamsson, Elina January 2011 (has links)
Sysmex XE-5000 är en automatiserad cellräknare som utför mätningar enligt olikamätprinciper, de två som tillämpats i projektet är RF/DC(Radio Frequency/DirectCurrent) samt Flödescytometri med halvledarlaser. RF/DC bygger på förändringari radiofrekventa resistansen och likspänningsresistansen. Förändringar i denradiofrekventa resistansen (RF) ger information om densiteten i cellernas inre(exempelvis kärnans storlek) och förändringar i likspänningsresistensen (DC) gerinformation om blodcellernas storlek. Flödescytometri definierar ett mått påcellers fysiologiska och kemiska egenskaper. Detektion av cellerna sker genom attde bestrålas med en laserstråle samtidigt som de passerar en och en i instrumentet.Informationen som fås ut från flödescytometri inkluderar spritt ljus ochfluorescens. Sysmex XE-5000 arbetar med flera olika felmeddelanden, så kalladelarm. Ett eller flera larm indikerar att det finns en ökad risk för förekomst avabnormala celler och kan enbart uteslutas genom en manuell differentialräkning. Istudien har tre larm, vilka indikerar närvaron av onormala leukocyter, undersökts:”Blasts?”, ”Atypical Lympho?” och ”Abn Lympho/L_Blasts?”. Syftet medprojektet är att jämföra nuvarande beräkningar med en ny mjukvara (eMM) förlarmen och utvärdera om de ger ett mindre antal falskt positiva larm frånhematologiinstrumentet Sysmex XE-5000. Prover med något av ovanstående larmvaldes ut och analyserades först med nuvarande inställningar på instrumentet ochdärefter med de nya beräkningarna för eMM. Resultatet visar på att antalet falsktpositiva prover minskar och även att antalet dubblettlarm minskar. / Sysmex XE-5000 is an automated cell counter that performs measurements withdifferent principles. The two applied in this project are RF/DC (RadioFrequency/Direct Current) and Flow cytometry with semiconductor laser. RF/DCis based on changes in radio frequency resistance and direct current voltage.Changes in RF provide information about the density of the cell’s internalstructure (e.g. the nucleus) and changes in DC provide information about the sizeof the blood cells. Flow Cytometry define as physiological and chemicalproperties of the cell. Detection of cells is achieved by the irradiation with a laserbeam while passing through one by one. The information obtained from flowcytometry includes scattered light and fluorescence. Sysmex XE-5000 works withseveral different error messages, so-called alarm. One or more alarm indicates thatthere is an increased risk for the presence of abnormal cells and this can only beruled out by a manual differential count. In this study three alarms, which indicatethe presence of abnormal white blood cells, were analyzed: “Blasts?”, AtypicalLympho?” and “Abn Lympho/L_Blasts?”. The project aims to compare thecurrent calculations with the new software (eMM) for the alarms and evaluate ifthey provide a smaller number of false positive alarms from the hematologyinstrument Sysmex XE-5000. Samples with one or two of the alarms wereselected and analyzed with the current settings and then with the new settings foreMM. The result showed that the number of false-positive samples was reducedand that the number of duplicate alarms decreased.
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The Association of Libarians in colleges of advanced education and the committee of Australian university librarians: The evolution of two higher education library groups, 1958-1997Oakshott, Stephen Craig, School of Information, Library & Archives Studies, UNSW January 1998 (has links)
This thesis examines the history of Commonwealth Government higher education policy in Australia between 1958 and 1997 and its impact on the development of two groups of academic librarians: the Association of Librarians in Colleges in Advanced Education (ALCAE) and the Committee of Australian University Librarians (CAUL). Although university librarians had met occasionally since the late 1920s, it was only in 1965 that a more formal organisation, known as CAUL, was established to facilitate the exchange of ideas and information. ALCAE was set up in 1969 and played an important role helping develop a special concept of library service peculiar to the newly formed College of Advanced Education (CAE) sector. As well as examining the impact of Commonwealth Government higher education policy on ALCAE and CAUL, the thesis also explores the influence of other factors on these two groups, including the range of personalities that comprised them, and their relationship with their parent institutions and with other professional groups and organisations. The study focuses on how higher education policy and these other external and internal factors shaped the functions, aspirations, and internal dynamics of these two groups and how this resulted in each group evolving differently. The author argues that, because of the greater attention given to the special educational role of libraries in the CAE curriculum, the group of college librarians had the opportunity to participate in, and have some influence on, Commonwealth Government statutory bodies responsible for the coordination of policy and the distribution of funding for the CAE sector. The link between ALCAE and formal policy-making processes resulted in a more dynamic group than CAUL, with the university librarians being discouraged by their Vice-Chancellors from having contact with university funding bodies because of the desire of the universities to maintain a greater level of control over their affairs and resist interference from government. The circumstances of each group underwent a reversal over time as ALCAE's effectiveness began to diminish as a result of changes to the CAE sector and as member interest was transferred to other groups and organisations. Conversely, CAUL gradually became a more active group during the 1980s and early 1990s as a result of changes to higher education, the efforts of some university librarians, and changes in membership. This study is based principally on primary source material, with the story of ALCAE and CAUL being told through the use of a combination of original documentation (including minutes of meetings and correspondence) and interviews with members of each group and other key figures.
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