The purpose of this study was to investigate a resuscitation algorithm that calculates the value of AMSA in real-time to direct the duration of post-shock chest compressions. We hypothesized that such an algorithm would shorten the time to achieve ROSC in swine. Swine were randomized into normal or infarcted myocardia and waveform guided or traditional resuscitation algorithm groups. VF was induced electrically and left untreated for 10minutes. Resuscitation was commenced with 1minute of compressions, resumption of mechanical ventilation, shock and epinephrine. In the traditional group, all shocks were followed by 2minutes of post-shock compressions. In the waveform guided group, AMSA was measured prior to shocks. If AMSA>20mV-Hz, post shock compression duration was shortened to 1minute.This study found that the waveform guided resuscitation algorithm to direct the duration of post-shock chest compressions had no significant effect on time to ROSC or AMSA values when compared to the traditional resuscitation algorithm.