The annexin-7 (ANX7) gene is located on human chromosome 10q21, a site long been hypothesized to harbor a tumor suppressor gene (TSG) associated with brain, prostate, breast and other cancers. To test whether ANX7 might be a candidate TSG, and its role in the molecular pathogenesis of malignant glioma. We examined the ANX7 expression levels in several kinds of cell lines, 139 glioma specimens and 84 gastric cancer specimences. Consistently, analysis of ANX7 protein expression in human glioma tumor a significantly higher rate (2.14 times) of loss of ANX7 expression in glioblastoma multiformes (GBM) as compared with low grade astrocytoma (p=0.04). The striking correlation ANX7 expression and the differentiation of gastric carcinoma (p = 0.001). ANX7 may play an important role in the tumor progression. Loss or reduced expression of ANX7 is possibly a biomarker for tumor cell progression