331 |
Mechanisms of mycobacteria-induced innate responsesYim, Chi-ho, Howard., 嚴志濠. January 2010 (has links)
published_or_final_version / Paediatrics and Adolescent Medicine / Doctoral / Doctor of Philosophy
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332 |
Re-sequencing of neuregulin 1 to search for rare variants in Chinese hirschsprung patientsTang, Wai-kiu., 鄧慧翹. January 2011 (has links)
published_or_final_version / Surgery / Master / Master of Research in Medicine
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333 |
Molecular characterization of toxigenic clostridium difficile by multiplex and real-time PCRChan, Chi-chiu, Elvin., 陳志超. January 2011 (has links)
published_or_final_version / Microbiology / Master / Master of Medical Sciences
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334 |
Molecular detection of streptococcus sinensis in blood culture samplesfrom hospitalized patients in Hong Kong: aneight-year retrospective studyChan, Shun-kwan., 陳信君. January 2011 (has links)
published_or_final_version / Microbiology / Master / Master of Medical Sciences
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335 |
Characterization of a novel streptococcus species associated with marine environmentLin, Ching-nga., 林靜雅. January 2011 (has links)
published_or_final_version / Microbiology / Master / Master of Medical Sciences
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336 |
Multilocus sequence typing for streptococcus agalactiaeNg, Yi-ting., 吳依婷. January 2011 (has links)
published_or_final_version / Microbiology / Master / Master of Medical Sciences
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337 |
Salt reduction initiatives in developed countries and lessons for China: a systematic reviewChan, Wai-gi, Jocelyn., 陳瑋之. January 2011 (has links)
published_or_final_version / Public Health / Master / Master of Public Health
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338 |
Identification of tumor suppressor genes in the commonly deleted region of chromosome 6q in NK-cell malignanciesGuo, Tianhuan., 郭天欢. January 2009 (has links)
published_or_final_version / Pathology / Doctoral / Doctor of Philosophy
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339 |
Structural and functional study of X-linked inhibitor of apoptosis (XIAP) protein and its interaction with ubiquitinHui, Sin-kam., 許倩琴. January 2011 (has links)
published_or_final_version / Chemistry / Doctoral / Doctor of Philosophy
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340 |
Molecular characterization of clostridium difficile isolates by capillary gel electrophoresis-based PCR ribotypingLam, Ching-to., 林正道. January 2012 (has links)
Backgroud:
Clostridium difficile infection (CDI) is a global concern since the emergence of the hyper-virulent strain NAP1/BI/027. The incidence of CDI has been increasing and active surveillance of Clostridium difficile epidemiology is of paramount importance. In studying the epidemiology of CDI, PCR ribotyping is a very useful method in finding the genetic relatedness of outbreak and epidemic strains. Characterisation of Clostridium difficile isolates can help surveillance and active monitoring, hence reducing the chance of potential outbreaks.
Aim:
The aims of this study is to investigate the epidemiology of Clostridium difficile in Hong Kong in the year 2010, and that of a Clostridium difficile outbreak in 2011 by using capillary gel electrophoresis-based PCR ribotyping.
Results:
Among the 307 toxigenic isolates, 139 isolates (45.3%) were characterized as existing ribotypes. Ribotype 012 was the predominant ribotype (17.3%), followed by ribotype 002/0 (15.6%). A total of 144 isolates (46.9%) were characterized as new ribotypes. The remaining 24 isolates (7.8%) were characterized as of high resemblance of existing ribotypes. A total of 8/12 isolates (66.7%) of the outbreak strains were found to be ribotype 002/0.
Conclusion:
The predominant strains of Clostridium difficile in 2010 was ribotype 012. The 2011 outbreak in Kowloon Hospital was an outbreak of Clostridium difficile ribotype 002/0. Capillary gel electrophoresis-based PCR ribotyping was showed to be a useful tool in investigation of Clostridium difficile outbreaks and study of Clostridium difficile epidemiology. / published_or_final_version / Microbiology / Master / Master of Medical Sciences
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