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In this thesis, an effect of a tyre defect on the driving dynamics of a vehicle is dealt with. The first part of the thesis is mainly concerned with the vehicle dynamics, road resistance, adhesion, orientation characteristics of the tyres and slowing down. This chapter is followed by an overview of the manufacturing process and construction of modern passenger car tyres. The practical part is focused on driving tests that are used to demonstrate the influence of tyre defects on handling characteristics of the vehicle. The main focus of this thesis is on directional variation, braking distance, deceleration and lateral acceleration. The very end of the thesis concentrates on tyre defect in higher speeds and its after-effects as well as precautions for mitigation of these after-effects.