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  • About
  • The Global ETD Search service is a free service for researchers to find electronic theses and dissertations. This service is provided by the Networked Digital Library of Theses and Dissertations.
    Our metadata is collected from universities around the world. If you manage a university/consortium/country archive and want to be added, details can be found on the NDLTD website.
11

Investigation of mutations in methylenetetrahydrofolate reductase deficiency

Low-Nang, Lawrence January 1991 (has links)
No description available.
12

The effects of folic acid deficiency on phagocytosis and susceptibility to infection

Pathak, Hemantkumar Yeshwantrai, 1929- January 1960 (has links)
No description available.
13

Homocysteine, folate and risk of atherosclerosis: from bench to bedside. / CUHK electronic theses & dissertations collection

January 2003 (has links)
Qiao, Mu. / "June 2003." / Thesis (Ph.D.)--Chinese University of Hong Kong, 2003. / Includes bibliographical references (p. 190-209). / Electronic reproduction. Hong Kong : Chinese University of Hong Kong, [2012] System requirements: Adobe Acrobat Reader. Available via World Wide Web. / Mode of access: World Wide Web.
14

Folate deficiency and methionine-dependence phenotype : impact on genome stability and breast cancer risk in BRCA1 and BRCA2 germline mutation carriers

Beetstra, Alexandra Johanna January 2006 (has links)
This thesis describes a study on the impact of selected nutrients, growth hormones and in vivo genome stability on breast cancer risk in BRCA1 or BRCA2 germline mutation carriers. Peripheral blood lymphocyes of BRCA germline mutation carriers and healthy non-carrier controls were studied for the impact of folic acid deficiency on genome damage and the methionine-dependence phenotype (MDP; in combination with common polymorphisms in one-carbon metabolism) on breast cancer risk, respectively. Plasma IGF-1 and IGFBP-3 were determined and chromosome 17 aneuploidy and Her2 amplification were assessed in mononucleated lymphocytes to establish the association of these markers on breast cancer risk in BRCA germline mutation carriers, independently or in combination with plasma folate, vitamin B12, homocysteine, selenium and common gene variants in the one-carbon metabolism, DNA repair genes or glutathionine S-transferase.
15

Maternal and infant essential fatty acids status in Havana, Cuba

Kraševec, Julia Maria. January 1999 (has links)
An adequate ingestion of essential fatty acids is required for optimal development of the central nervous system and visual acuity in infants. For breast feeding mothers, it is important that a diet containing an adequate balance of essential fatty acids of the n-6 and n-3 series be consumed as this is reflected in breast milk. The objective of this investigation was to determine the essential fatty acid status of breast feeding women and their infants in Havana, Cuba, with particular focus on the n-3 series. The group of 56 Cuban mothers and infants under investigation did not show biochemical or functional signs of poor essential fatty acid status. Based on the biochemical and functional data collected, it is conceivable to conclude that n-3 fatty acid deficiencies must be exceedingly rare, if they exist at all, in the population of breast feeding women and their infants residing in Havana, Cuba. (Abstract shortened by UMI.)
16

Isolation and partial characterization of the mouse gene for methylenetetrahydrofolate reductase (MTHFR)

Pai, Aditya P. January 1995 (has links)
Methylenetetrahydrofolate reductase (MTHFR), an important enzyme in folate metabolism, mediates the conversion of 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate which serves as the carbon donor for the conversion of homocysteine to methionine. It is also inhibited by S-adenosylmethionine which has shown to be actively demethylated to form S-adenosylhomocysteine, which is hydrolysed to homocysteine. MTHFR deficiency exhibits well-documented clinical and biochemical symptoms. The human MTHFR cDNA was isolated by Goyette et al (1994), and fifteen mutations have been identified at this locus. / An animal model would prove to be useful for designing therapeutic approaches for understanding the pathogenesis of this genetic disease at the molecular level. The mouse MTHFR gene and cDNA have been isolated and partially characterized. Four genomic clones were isolated by library screening. One of these clones (clone 3) contained the 5$ sp prime$ end of the gene and was completely characterized. The clone was shown to have no rearrangements and is to be used to design targeting vectors for 'knockout mice' and mice carrying a common mutation which has been postulated to be a genetic risk factor for cardiovascular disease. The other three clones contain the remaining 3$ sp prime$ portion of the gene. The coding portion has approximately 90% homology with the human cDNA and also shows a similar gene structure. / A 2.2 Kb mouse MTHFR cDNA was isolated by library screening and was found to contain a 320 base pair extension at the 5$ sp prime$ end which has not been found in the human cDNA. The cDNA contains exons -1 -3, but also contains two possibly unspliced introns. A portion of this cDNA can however still be used to rescreen libraries to isolate a full length cDNA. The above research is the first genetic data on the mouse MTHFR gene and provides the basis for future research involving mouse models of MTHFR deficiency.
17

Implications of methionine and S-adenosylmethionine for the brain function

Shalchi-Toosi, Marjan January 1993 (has links)
We have studied the effect of S-adenosylmethionine (SAM) on tail flick latency in the rat. We also studied the effect of methionine the immediate precursor of SAM. Administration of methionine to the rat increases brain SAM, but little is known about its behavioral effects. Long-Evans rats were given SAM and methionine orally at different doses and tail-flick latency was measured at various times. Both methionine and SAM increased tail-flick latency, but methionine did so at a lower dose. A biochemical study showed that methionine was more effective than SAM in raising brain SAM probably because it is transported better into brain. The biochemical measurements were not consistent with the idea that the effects of SAM and methionine were mediated by an increase in brain 5-HT. / Folate deficiency can lower brain SAM levels and cause depression. Thus, methionine, which raises brain SAM, may overcome the effects of folate deficiency. Seven day food records were done by 26 psychiatric outpatients who were stable on lithium treatment. Eight patients had mean daily folate intakes below those recommended. Some of those with low folate intake had high methionine intake consistent with the idea that methionine could substitute metabolically for folate deficiency. Daily methionine intakes ranged from 13 to 304% of the recommended intake. As methionine had behavioral effects in the rat at doses much less than the daily dietary intake this raises the question of whether varying daily intakes of methionine in humans have behavioral implications. (Abstract shortened by UMI.)
18

ASCORBIC ACID AND THE FLAVIN-CONTAINING MONOOXYGENASE

BRODFUEHRER, JOANNE IRENE. January 1986 (has links)
Thesis (Ph. D.)--University OF MICHIGAN.
19

Remodelling of the periodontium in orthodontically treated guinea pigs on restricted vitamin C intake a thesis submitted in partial fulfillment ... in orthodontics ... /

Dierkes, J. Michael. January 1976 (has links)
Thesis (M.S.)--University of Michigan, 1976.
20

Remodelling of the periodontium in orthodontically treated guinea pigs on restricted vitamin C intake a thesis submitted in partial fulfillment ... in orthodontics ... /

Dierkes, J. Michael. January 1976 (has links)
Thesis (M.S.)--University of Michigan, 1976.

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