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A study of urinary-type plasminogen activators in biological fluids張濤, Cheung, To. January 1996 (has links)
published_or_final_version / Biochemistry / Doctoral / Doctor of Philosophy
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Modulation of plasminogen activator and plasminogen activator inhibitor system in murine macrophage /Kung, Kam-pun. January 1900 (has links)
Thesis (M. Phil.)--University of Hong Kong, 1992.
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A study of urinary-type plasminogen activators in biological fluids /Cheung, To. January 1996 (has links)
Thesis (Ph. D.)--University of Hong Kong, 1996. / Includes bibliographical references (leaf 166-197).
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Transcription activation and DNA binding by the MelR proteinHoward, Victoria Jayne January 2001 (has links)
No description available.
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Factors affecting plasminogen activator activity in bovine and porcine oocyte-cumulus cell complexes matured in vitroKim, Nam-hyung 06 May 1993 (has links)
Effects of phorbol myristate acetate (PMA), dibutyryl cyclic
AMP (dbcAMP), 6-dimethylaminopurine (6-DMAP), okadaic acid
(OA), cycloheximide (CHX), actinomycin D (AcD) and tunicamycin
(TuM) on plasminogen activator (PA) activity and maturation rate
in bovine and porcine oocyte-cumulus cell complexes (BOCC and
POCC, respectively) in vitro were determined. Plasminogen
activator activity was measured by SDS-PAGE, casein-agar
zymography and densitometry. Three plasmingen-dependent lytic
zones (92-95, 71-73 and 49-51 kD) and one PA inhibitor (52 kD)
were observed in BOCC. Immunoprecipitation and amiloride
sensitivity suggested that the 49-51 kD protease is a urokinase
type PA (uPA), the 71-73 and 92-95 kD proteases are a tissue
type PA (tPA) and tPA-PAI complex, respectively, and the PAI is
PAI-1. In POCC, two plasminogen activators (71-78 and 93-96 KD)
were observed. Lack of amiloride sensitivity suggested that the 71
-78 kD band is a tPA and the 93-96 kD band is possibly a tPA-PAI
complex. Increasing dbcAMP in the culture medium increased
activity in both BOCC and POCC in dose-dependent fashion (P<0.05).
In BOCC cultured with PMA, total PA activity increased, however
high concentrations of PMA (10 and 100 ng/ml) decreased tPA
activity in matured POCC. Plasminogen activator activity
decreased in 6-DMAP, actinomycin D and cycloheximide and oocyte
maturation was also inhibited in these treatments. When POCC
were treated with 25 nM OA, uPA activity was observed.
Plasminogen activator activity increased in either BOCC or POCC
treated with up to 25 nM OA, however PA activity decreased at
concentrations greater than 75 nM (P<0.05). Incubation of BOCC
with tunicamycin reduced the molecular mass of tPA and tPA-PAI
complex and PAI-1 by 5-10%, however PA activity was not
inhibited. These data suggest that BOCC matured in vitro produce
uPA, tPA and PAI-1 however POCC produce only tPA and PAI. The
production of PA and PAI by either BOCC or POCC is associated
with oocyte maturation and influenced by stimulators of the
protein kinase A and C, modulators of intracellular phosphorylation
and metabolic inhibitors. / Graduation date: 1993
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Modulation of plasminogen activator and plasminogen activator inhibitor system in murine macrophage龔金斌, Kung, Kam-pun. January 1992 (has links)
published_or_final_version / Biochemistry / Master / Master of Philosophy
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Sonic hedgehog in the vertebrate retina /Moshiri, Ala. January 2004 (has links)
Thesis (Ph. D.)--University of Washington, 2004. / Vita. Includes bibliographical references (leaves 99-108).
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The regulation and function of plasminogen activator inhibitor type 2 /Dickinson, Joanne L. January 1995 (has links) (PDF)
Thesis (Ph.D.) - University of Queensland, 1996. / Includes bibliographical references.
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Study of plasminogen activation by human trophoblasts /Jojart, Istvan, January 1997 (has links)
Thesis (Ph.D.)--Memorial University of Newfoundland, Faculty of Medicine, 1997. / Typescript. Bibliography: leaves [222]-256.
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Post-transcriptional regulation of plasminogen activator inhibitor type 2Tierney, Marcus John, 1973- January 2002 (has links)
Abstract not available
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