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Clinical and pharmacological studies on cytosine arabinoside in acute leukemiaSchonk, Aleida Maria, January 1900 (has links)
Thesis (doctoral)--Katholieke Universiteit te Nijmegen.
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Acute pancreatitis complications and antiprotease treatment /Berling, Rikard. January 1998 (has links)
Thesis (Doctoral)--Departments of Surgical Pathophysiology and Anaesthesiology, University of Lund, University Hospital MAS. / Added t.p. with thesis statement inserted. Summary in Swedish. Includes bibliographical references.
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Management and outcome in non ST-elevation acute coronary syndromes : similarities and differences between women and men /Alfredsson, Joakim, January 2009 (has links) (PDF)
Diss. (sammanfattning) Linköping : Linköpings universitet, 2009. / Härtill 4 uppsatser.
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Cellular mechanisms of L-arginine induced experimental acute pancreatitisMasood, Omar January 2013 (has links)
Introduction: Impairment of cytosolic calcium ([Ca2+]i) signaling and in particular calcium overload has emerged as a possible unifying mechanism for precipitating acute pancreatitis (AP.) In the L-arginine (L-arg) experimental model of AP, nitric oxide (NO) has been implicated however the disease progression is largely unaffected by nitric oxide synthase (NOS) inhibitors (8). Additionally, L-ornithine (L-orn), a NOS-independent metabolite of L-arg, has been shown to be potent at inducing AP (28). Both L-arg and L-orn activate calcium-sensing like receptors (CaSR) (31) such as the GPRC6a which may be responsible for initiating the [Ca2+]i overload. The aim of this study is to investigate the effects of L-arg and L-orn on pancreatic acinar cells that maybe linked to the pathophysiology of AP. Furthermore to provide an alternative theory to the NO mediated ones, in particular that L-arg induces toxic changes in [Ca2+]i via a GPRC6a like receptor. Methods: Whole pancreata were harvested from male Sprague Dawley rats. Pancreatic acinar cells were isolated by collagenase digestion. [Ca2+]i was measured using fura-2 imaging, and cell viability assessed using physiological CCK. Oxidative stress was measured using dichlorofluorescein (DCF) and cell death was quantified using trypan blue exclusion. Results: L-arg and L-orn (100mM) induced spike-like, reversible increases in [Ca2+]i in 46% and 74% of cells and Ca2+ overload in 11% and 26% respectively. At 500 mM both induced Ca2+ overload in all cells however this was also seen with the osmotic control, mannitol. Isosmotic L-arg and L-orn (100mM) induced only reversible increases in [Ca2+]i. Neither L-arg nor L-orn had significant effects on CCK-evoked [Ca2+]i oscillations. Both L-arg and L-orn induced significant oxidative stress responses (22% and 37% of a maximum response seen with 3mM H202, respectively). Both L-arg and L-orn caused cell death in 76% +/- 4 and 89% +/- 7 at 3 hours respectively, compared to 35% +/- 4 and 40% +/- 3 with controls (Hepes, Glycine). Conclusion: The data suggests that the L-arg and L-orn causes significant increase in oxidative stress and cell death. The data suggests that although changes in [Ca2+]i were induced by both L-arg and L-orn the large concentrations used experimentally are likely to induce significant osmotic effects.
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Acute renal failure: cost-effectiveness analysis and expert probability predictions of prevention and treatment strategiesDurtschi, Amy J. 06 August 2003 (has links)
No description available.
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Evaluation on welfare in the husbandry of laboratory rabbitsGunn, Deborah January 1994 (has links)
No description available.
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Evaluation on micro-AMS at early detection of acute renal transplant rejection黃國權, Wong, Kwok-kuen. January 2008 (has links)
published_or_final_version / Medical Sciences / Master / Master of Medical Sciences
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The role of platelets in acute inflammationPeters, Mark John January 2001 (has links)
No description available.
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Studies of the granulocyte-macrophage colony stimulating factor in leukaemiaFreeburn, Robin William January 1997 (has links)
No description available.
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Oxidative damage to extracellular proteins and lipids during acute lung injuryQuinlan, Gregory John January 1995 (has links)
No description available.
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