published_or_final_version / Zoology / Doctoral / Doctor of Philosophy

The turtle is a unique model of anoxic survival. The turtle's brain can tolerate total oxygen deprivation for hours to days as well as prevent high levels of mitochondrial-derived free radicals upon re-oxygenation. Because of its ability to prevent elevated free radical generation, the turtle has also become recognized as a model of exceptional longevity. We are employing the turtle model for an investigation into the regulation of a key antioxidant enzyme system - methionine sulfoxide reductases (Msrs), primarily MsrA and MsrB. The Msr system is capable of reversing oxidation of methionines in proteins and Msr subtypes have been implicated in protecting tissues against oxidative stress, as well as, enhancing the longevity of organisms from yeast to mammals. Preliminary data, unpublished results, indicate that MsrA protein and transcripts are elevated by anoxia. A recent study on Caenorhabditis elegans demonstrated that FOXO is involved in activation of the MsrA promoter. Using the turtle MsrA promoter sequence we worked to determine which regions in the promoter are necessary for activation by anoxia. The results of the present study were 1) to prepare a TAT-FOXO3a fusion protein which could penetrate animal cells and 2) to construct a FOXO3a expression vector for transcription studies on MsrA expression. / by Diana Navarro. / Thesis (M.S.)--Florida Atlantic University, 2012. / Includes bibliography. / Electronic reproduction. Boca Raton, Fla., 2012. Mode of access: World Wide Web.

Collective title supplied by cataloguer. / Lacks contents and abstract. / Includes bibliographical references. / 8 v. : / Title page, contents and abstract only. The complete thesis in print form is available from the University Library. / Collection of journal articles and reprints presented by the author (either by; or, co-authored by the author) for admission to the degree / Thesis (M.D.)--University of Adelaide, 1942

No description available.

published_or_final_version / Zoology / Master / Master of Philosophy

3 v. : ill. (part col.), 1 map ; 30 cm. / Title page, contents and abstract only. The complete thesis in print form is available from the University Library. / Thesis (Ph.D.)--University of Adelaide, Dept. of Restorative Dentistry, 1983

Thesis (M. Sc.)--Carleton University, 2004. / Includes bibliographical references (p. 119-132). Also available in electronic format on the Internet.

Mémoire (M.Ps.)--Université du Québec, 2000. / En tête du titre: Université du Québec, mémoire présenté à l'Université du Québec à Chicoutimi comme exigence partielle de la maîtrise en psychologie offerte à l'Université du Québec à Chicoutimi en vertu d'un protocole d'entente avec l'Université du Québec à Trois-Rivières. CaQCU Document électronique également accessible en format PDF. CaQCU

Thesis (Honors)--College of William and Mary, 2009. / Includes bibliographical references (leaves 58-66). Also available via the World Wide Web.

Thesis (Ph. D.)--Illinois State University, 1999. / Title from title page screen, viewed July 24, 2006. Dissertation Committee: Steven A. Juliano (chair), Wayne A. Riddle, Scott K. Sakaluk, Charles F. Thompson, Douglas W. Whitman. Includes bibliographical references (leaves 126-133) and abstract. Also available in print.