Barros et al. (2018) suggested that individuals with a diagnosis of down syndrome (DS) and/or autism spectrum disorder (ASD) face challenges in acquiring adaptive daily living skills (ADLs). As a result, more intensive support may be required to acquire such skills and quality of life (QoL) may be impacted for those individuals and their parents/caregivers/legal guardians. The purpose of this study was to teach children with a diagnosis of down syndrome (DS) or autism spectrum disorder (ASD) oral hygiene skills, specifically toothbrushing, utilizing basic video modeling. Three children between the ages of four – 11 with a diagnosis of DS or ASD viewed video models portraying a similar age peer completing the toothbrushing task. A concurrent multiple baseline across participants design was used and independence in tooth brushing was monitored. Results suggested that utilizing basic video modeling can increase correct independent responding in tooth brushing. When taught ADLs, individuals with a diagnosis of DS or ASD may be able to increase independence in everyday life such as feeding, using the bathroom, or living independently. Furthermore, acquiring ADLs can increase the QoL for individuals with a diagnosis of DS or ASD and for the parents/caregivers/legal guardians of those individuals.