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  • About
  • The Global ETD Search service is a free service for researchers to find electronic theses and dissertations. This service is provided by the Networked Digital Library of Theses and Dissertations.
    Our metadata is collected from universities around the world. If you manage a university/consortium/country archive and want to be added, details can be found on the NDLTD website.
1

Adipose related signaling in syndromic obesity /

Zheng, Yue, January 2009 (has links)
Thesis (M.S.) in Biochemistry--University of Maine, 2009. / Includes vita. Includes bibliographical references (leaves 44-48).
2

Genetic and physiological investigations of monogenic disorders resulting in severe insulin resistance and aberrant adipose tissue distribution

Suliman, Sara January 2011 (has links)
Background: Regional adiposity and in particular central adiposity is associated with a hazardous metabolic profile, insulin resistance (IR), hypertension and increased cardiovascular mortality whilst gluteo-femoral fat (peripheral fat) is protective. Extreme phenotypes, especially those due to monogenic disorders, are experiments of nature, which have been pivotal in identifying genes involved in disease. The hypothesis tested in this thesis was that investigating individuals with monogenic causes of regional adiposity and IR would identify genes and physiological processes contributing to their phenotype. Methods: Two families with balanced translocations, sixty-nine patients with partial lipodystrophy and eight individuals with lipoma were investigated. Genetic investigations included mapping of balanced translocations using fluorescent in-situ hybridisation, DNA and cDNA sequencing and gene expression studies. In vivo investigations of adipose tissue included microdialysis and measurement of adipose tissue blood flow. Results: Genetic and physiological factors contributing to regional adipose tissue deposition and IR were identified in (1) individuals with lipodystrophy where mutations were identified in eleven families including one novel PPARG mutation V450M. Also a skinfold ratio was developed for the clinical diagnosis of partial lipodystrophy (2) a family with a balanced I translocation, IR and growth retardation, digenic disruption of INSR and CHN2 was identified, which accounted for the clinical phenotype (3) a family with a balanced translocation, central adiposity and peas associated with disruption of KIBRA (4) lipoma tissue relative to adjacent healthy subcutaneous tissue, where differential gene expression profiles were identified, we also demonstrated reduced metabolic flexibility and reduced lipolysis in lipoma relative to healthy adipose tissue despite no change in adipose tissue blood flow. Conclusion: Investigating individuals with extreme phenotypes and monogenic causes of regional adiposity and IR identified key genetic and physiological factors.
3

Effects of high fat feeding on determinants of glucose tolerance and brain insulin delivery in dogs /

Kaiyala, Karl John. January 1997 (has links)
Thesis (Ph. D.)--University of Washington, 1997. / Vita. Includes bibliographical references (leaves [102]-118).

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