Thesis (Ph. D.)--Virginia Commonwealth University, 2008. / Prepared for: Dept. of Pharmaceutics Bibliography: leaves 120-129.

Thesis (doctoral)--Ludwig Maximilians-Universität zu München, 1979.

The current interest in the secretions of the adrenal cortex is shared by physiologist, physician and pharmacologists alike. such attention is not surprising in the case of a gland which is immediately essential to life, which can produce syndromes as varied as precocious puberty, virilisation; Addison's disease; Cushing's syndrome, and the newly described hyperaldosteronism syndrome of Conn (1955), a gland which has been implicated in the parthenogenesis of diabetes (Hoet and Lukens, 195; Jackson, 1955), hypertension (Sepeika, 1948, 1955), pre-eclampsia, and atherosclerosis, and which profoundly effects so many of the metabolic processes of the body. The need for accurate measurement of adrenocortical function has therefore been accentuated in recent years. The purpose of this study was to find out as direct a method as possible for determining the rate of secretion of this gland and to define with this method the norms and normal variations.

Thesis (doctoral)--Lund University, 1994. / Added t.p. with thesis statement inserted.

Thesis (doctoral)--Lund University, 1994. / Added t.p. with thesis statement inserted.

Thesis (Ph. D.)--University of Wisconsin--Madison, 1962. / Typescript. Vita. eContent provider-neutral record in process. Description based on print version record. Includes bibliographical references.

Thesis (M.S.)--University of Michigan, 1967.

Thesis (M.S.)--University of Michigan, 1967.

by Linda Shiou-mei Ooi. / Thesis (M.Phil.)--Chinese University of Hong Kong, 1993. / Includes bibliographical references (leaves 95-109). / Abstract --- p.i / Acknowledgements --- p.iii / List of Figures --- p.viii / Chapter Chapter I. --- Introduction --- p.1 / Objectives --- p.4 / Chapter Chapter II. --- Literature Review --- p.5 / Chapter II. 1. --- Lipoprotein-Lipids --- p.5 / Chapter II.1.1. --- General Concept and Metabolism of Lipoprotein-lipids --- p.5 / Chapter II. 1.2. --- Factors affecting plasma lipoprotein-lipids --- p.11 / Chapter II. 1.2.1. --- Ageing --- p.11 / Chapter II. 1.2.2. --- Obesity --- p.12 / Chapter II. 1.2.3. --- Diet --- p.13 / Chapter II. 1.2.4. --- Alcohol --- p.13 / Chapter II. 1.2.5. --- Cigarette smoking --- p.14 / Chapter II. 1.2.6. --- Exercise --- p.14 / Chapter II. 1.2.7. --- Gender differences --- p.14 / Chapter II.2. --- Sex Hormones --- p.14 / Chapter II.2.1. --- General concepts of sex hormone-production and the metabolism of sex hormones --- p.15 / Chapter II.2.1.1. --- Biosynthesis of testosterone --- p.16 / Chapter II.2.1.2. --- Metabolism of testosterone --- p.17 / Chapter II.2.1.3. --- Dihydrotestosterone (DHT) --- p.18 / Chapter II.2.1.4. --- Androstenedione --- p.18 / Chapter II.2.1.5. --- Biosynthesis of estrogen in men --- p.18 / Chapter II.2.1.6. --- Metabolism of estrogen --- p.19 / Chapter II.2.2. --- Factors affecting sex hormone levels in plasma --- p.19 / Chapter II.2.2.1. --- Sex hormone binding globulin (SHBG) --- p.19 / Chapter II.2.2.2. --- Sampling time --- p.19 / Chapter II.2.2.3. --- Stress and acute or chronic non-endocrine illnesses --- p.20 / Chapter II.2.2.4. --- Ageing --- p.21 / Chapter II.2.2.5. --- Diet and nutrition --- p.21 / Chapter II.2.2.6. --- "Medication, drugs and alcohol" --- p.22 / Chapter II.2.2.7. --- Body composition and obesity --- p.22 / Chapter II.2.2.8. --- Variations in states of sleep-wake cycle --- p.23 / Chapter II.2.2.9. --- Levels of physical and sympathetic nervous system activity --- p.23 / Chapter II. 3. --- The relationship between sex hormones and lipoproteins --- p.24 / Chapter II.3.1. --- "Gender difference in sex hormones, menopause and lipoprotein-lipids" --- p.24 / Chapter II.3.2. --- "Interventional study, exogenous sex hormone and lipoprotein-lipidsin men" --- p.25 / Chapter II.3.3. --- The relationships of endogenous sex hormones and lipoprotein-lipids --- p.26 / Chapter Chapter III. --- Materials and Methods --- p.28 / Chapter III.l. --- Subjects and Sampling Methods --- p.28 / Chapter III.2. --- Quantitation of serum lipoprotein-lipids --- p.29 / Chapter III.2.1 --- Determination of cholesterol and triglyceride --- p.29 / Chapter Table III.2.1.A. --- Intra-assay variations for cholesterol and triglyceride --- p.30 / Chapter Table III.2.1.B. --- Inter -assay variations for Cholesterol and Triglyceride --- p.30 / Chapter III.2.2. --- Determination of HDL-Cholesterol and its subfractions --- p.31 / Chapter Table III.2.2. --- Intra- and inter-assay variation for HDL-cholesterol --- p.31 / Chapter III.2.3. --- Determination of VLDL-C and LDL-C --- p.32 / Chapter III.2.4. --- Quantitative determination of serum apolipoproteins and Lp(a) --- p.32 / Chapter III.2.4.1. --- Determination of Apolipoproteins A-I and B --- p.33 / Chapter III.2.4.2. --- Determination of Lipoprotein (a) --- p.33 / Chapter III. 3. --- Quantitative determination of sex hormones --- p.33 / Chapter III.3.1. --- For urinary unconjugated and serum total testosterone --- p.34 / Chapter III.3.1.1 --- Experimental Procedures --- p.35 / Determination of the optimal antibody titre --- p.35 / Establishment of a standard curve and quality controls --- p.35 / Preparation of standards --- p.35 / Purification of radioactively-labelled 3H-testosterone --- p.37 / Preparation of charcoal- stripped urine as zero calibrator (blank) --- p.37 / Preparation of spiked urine or plasma --- p.38 / Preparation of samples for RIA --- p.38 / RIA --- p.39 / Calculation --- p.40 / Chapter III.3.1.2. --- Characteristics of the radioimmunoassay for testosterone --- p.40 / Sensitivity --- p.40 / Precision studies --- p.42 / Within- and between- batch imprecisions --- p.42 / Chapter Table III.3.1.2.A. --- Within-run variation --- p.42 / Chapter Table III.3.1.2.B. --- Between-run variation --- p.42 / Recoveries --- p.43 / Chapter Table III.3.1.2.C. --- "The recoveries of known amounts of testosterone added to charcoal-stripped urine, between immunoassays" --- p.43 / Test of linearity --- p.43 / Comparison with another procedure --- p.43 / Cross reactivity of the antiserum --- p.44 / Procedure --- p.46 / Chapter Table III.3.1.2.D. --- Cross reactivity of some naturally occurring steroids with testosterone antiserum --- p.47 / Chapter III.3.2 --- For urinary total testosterone --- p.47 / Test of linearity and recovery --- p.48 / Chapter III.3.3. --- For urinary unconjugated and serum total 17β-Estradiol --- p.50 / Chapter III.3.3.1 --- Experimental procedure --- p.50 / Determination of the optimal antibody titre --- p.50 / Establishment of a standard curve and quality controls --- p.52 / Preparation of standards --- p.52 / Preparation of tracer 3H-estradiol and construction of a standard curve --- p.52 / Preparation of spiked control urine or plasma --- p.52 / Preparation of samples for RIA --- p.53 / Chapter III.3.3.2. --- Characteristics of the radioimmunoassay for E2 --- p.53 / Sensitivity --- p.54 / Precision studies --- p.54 / Within- and between- batch imprecisions --- p.54 / Chapter Table III.3.3.2.A. --- Within-run variation of known amount of E2 added to charcoal- stripped urine --- p.54 / Chapter Table III.3.3.2.B. --- Between-run variation of known amount of e2 added to charcoal- stripped urine --- p.54 / Recoveries --- p.56 / Chapter Table III.3.3.2.C. --- "The recoveries of known amount of e2 added to charcoal- stripped urine, between immunoassays" --- p.56 / Test of linearity --- p.56 / Comparison with another procedure --- p.56 / Chapter III.3.4. --- For urinary total estradiol --- p.58 / Test of linearity and recovery --- p.58 / Chapter III.4. --- Determination of serum sex hormone-binding globulin (SHBG) --- p.60 / Chapter III.5. --- Determination of urinary unconjugated Cortisol --- p.60 / Chapter III.6. --- Statistical methods --- p.62 / Chapter III.6.1. --- Biological Variations --- p.62 / Chapter III.6.2. --- Univariate and multivariate correlations --- p.62 / Chapter Chapter IV. --- Results --- p.64 / Chapter IV. 1. --- The characteristics of the experimental subjects and their lipoprotein-lipids profiles --- p.64 / Chapter Table IV. 1. A. --- The anthropometric and biochemical characteristics of the experimental male subjects --- p.64 / Chapter Table IV.1.B. --- The lipoprotein-lipids profiles in 46 healthy Hong Kong Chinese men --- p.65 / Chapter IV. 2. --- "Levels of sex hormones in serum and urine, and urinary free Cortisol" --- p.65 / Chapter Table IV.2. --- The sex hormones at serum and urinary levels and urinary free Cortisol in 46 healthy Hong Kong Chinese men --- p.66 / Chapter Table IV.2.A. --- Formula for the indirect calculation of unbound (free) testosterone levels in plasma --- p.67 / Chapter Table IV.2.B. --- Formula for the indirect calculation of unbound (free) 17β-estradiol levels in plasma --- p.68 / Chapter IV. 3. --- Biological variations --- p.69 / Chapter Table IV. 3. --- "The biological variations of serum lipoprotein-lipids, serum sex hormones and urinary sex hormones and Cortisol in 46 healthy Hong Kong Chinese men" --- p.69 / Chapter Table IV.3.A. --- Correlations of serum lipoprotein-lipids between short-term (3- week) variations --- p.70 / Chapter Table IV.3.B. --- Correlations of serum and urinary sex hormones and urinary unconjugated Cortisol between short-term (3-week) variations --- p.70 / Chapter IV. 4. --- Univariate correlation --- p.71 / Chapter Table IV.4. --- The univariate correlation table --- p.72 / Chapter IV.4.1. --- Inter-relationship among serum and urinary sex hormones --- p.73 / Chapter IV.4.2. --- Urinary free Cortisol and sex hormones and serum lipoprotein-lipids --- p.73 / Chapter IV.4.3. --- Correlation between urinary sex hormones and serum lipoprotein- lipids --- p.73 / Chapter IV.4.4. --- Correlations among serum lipoprotein-lipids --- p.74 / Chapter IV.4.5. --- Correlations between serum lipoprotein-lipids and sex hormones --- p.74 / Chapter IV.4.6. --- "Correlations between anthropometric variables, sex hormones and lipoprotein-lipids" --- p.75 / Chapter IV.4.7. --- Correlation of the ratio of HDL2 and HDL3 and other variables --- p.76 / Chapter IV. 5. --- Multiple linear stepwise regression --- p.77 / Chapter Table IV.5. --- "Stepwise multiple linear regression of lipoprotein-lipids on BMI, W/H Ratio, and Age" --- p.77 / Chapter Table IV.5. A. --- "Stepwise multiple linear regression of lipoprotein-lipids on BMI, W/H Ratio, Age, SHBG, and serum and urinary Sex Hormones" --- p.80 / Chapter Table IV.5.B. --- "Stepwise multiple linear regression of lipoprotein-lipids on BMI, W/H Ratio, Age, SHBG, Triglyceride and serum and urinary Sex Hormones" --- p.81 / Chapter Chapter V. --- Discussion --- p.82 / Chapter V. l. --- Experimental subjects and their lipoprotein-lipids profiles --- p.82 / Chapter V. 2. --- Levels of sex hormones in serum and urine --- p.84 / Chapter Table V.2. --- Values of sex steroids in 46 healthy Hong Kong Chinese men compared to others cited in literature --- p.85 / Chapter V. 3. --- "17β-Estradiol,atherogenic lipoprotein-lpids and HDL3" --- p.88 / Chapter V. 4. --- "Testosterone, and HDL-C and its subfractions" --- p.90 / Chapter Chapter VI. --- Conclusions --- p.92 / References --- p.95 / Appendices --- p.110

Diss. (sammanfattning) Uppsala : Uppsala universitet, 2005. / Härtill 4 uppsatser.