Medium-voltage (MV) motor drives have found widespread applications in various heavy industries, such as in the oil and gas sectors, production plants, and process industries. Conventional cascaded H-bridge (CHB) multilevel inverters dominate the medium-voltage industrial drives domain due to their modularity, scalability, and reliability. The most prevalent CHB topology in the drive industry is based on the diodes-front-end (DFE) rectifier, which greatly limits the industrial application of the conventional CHB drives where the ability of handling regeneration is required. The main objective of this thesis is to develop a low-cost, high performance, reliable regenerative CHB drive. The thesis is concentrating on reducing the grid-tied filter size, shrinking the DC-link capacitors, improving the system’s performance and reliability through advanced control techniques. First, to reduce the number of passive filter components, a new sideband harmonic active filtering strategy based on the carrier-shifting method is proposed for regenerative CHB drives. This proposed approach extends the carrier shifted PWM method for regenerative CHB drives to further reduce the required passive filter size significantly and thus improves the overall size, cost, and efficiency while complying with IEEE Std 519-2014 grid standard. Second, a novel voltage ripple controller is proposed to reduce the dc-link capacitance in the three-phase regenerative CHB drive without adding extra measurements. Third, to achieve a faster dynamic response and the multi-objective performance during the control of CHB drives, a novel high-performance predictive control with long prediction horizons is proposed to improve the control performance of the CHB multilevel inverters. The formulation of the proposed high-performance finite control set model predictive control (FCS-MPC) is explained in detail and analyzed to reduce the real-time computation burden. Last, when a fault is detected in the regenerative CHB drive system, the reliability and fault-tolerant ability are considered as the main issues. To improve the drive system reliability, a non-symmetrical selective harmonic elimination (SHE) formulation is proposed to extend the output voltage range with a good harmonic profile under post-fault conditions. Experimental validation of the proposed algorithms is presented for the operation of a scaled-down seven-level regenerative CHB drive system. These proposed techniques make the regenerative CHB drive a promising solution for future medium-voltage regenerative drive applications in terms of cost, performance, and reliability. / Thesis / Doctor of Philosophy (PhD)