Philosophiae Doctor - PhD / Search for an ideal scaffold for guided tissue/bone (GTR/GBR) regeneration continues as till now none of the commercially available GTR/GBR membrane fulfils the desired criteria. Currently, a variety of new materials and techniques have been investigated all over the world to improve the properties of GTR/GBR membranes. In the recent past three dimensional bioactive scaffolds composed of natural polymers have gained enormous popularity as potential future GTR/GBR devices. Electrospinning has emerged as one of the relatively simple, cost effective and efficient technique to fabricate three dimensional nanofibrous scaffolds in the field of tissue engineering. The rationale of this project is to investigate the natural polymers based bioactive nanofibrous scaffolds for GTR/GBR applications in the field of Periodontology.