Seclusion is a behavioral management intervention used at the practicum site to manage maladaptive behaviors seen in mentally ill patients. Seclusion is not a voluntary occurrence for patients. The practice-focused question asked: Can development of an evidence-based practice (EBP) guideline help guide health care providers in the development of a multisensory room as an alternative to seclusion for people living with mental health disorders (PLWMHD)? The purpose of this DNP project was to develop the EBP guideline for a multisensory room as an alternative to seclusion for the practicum site. To aid in the development of the EBP guideline, the AGREE II model provided the framework for quality improvement related to better patient outcomes. The sources of evidence for this DNP project were drawn from the systematic review of the literature related to primary, original, and peer-reviewed journals. The electronic databases used for conducting these searches were CINAHL with Plus Full, Medline with full text, PsycINFO, SocINDEX and the Walden University library. The analytical strategy for this DNP project was to conduct a content analysis of research studies for recurrent themes, related to maladaptive behaviors, seclusion, and sensory rooms, in order to develop the draft guideline. Subsequently, 14 experts were selected for review of the resultant draft guideline using the AGREE II tool. Expert input and feedback was incorporated to achieve consensus on the final version. The potential implication for nursing practice is patient safety for a targeted population. The positive social change expected to occur for health care providers at the practicum site is the use of a best-practice tool based on evidence during their provision of care for PLWMHDs.