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1	An investigation into gastric myoelectrical activity in response to drug treatment during ageing and in a mouse model of Alzheimer's disease. / CUHK electronic theses & dissertations collection January 2013 (has links) Wang, Hui Chuan. / Thesis (Ph.D.)--Chinese University of Hong Kong, 2013. / Includes bibliographical references (leaves 184-202). / Electronic reproduction. Hong Kong : Chinese University of Hong Kong, [2012] System requirements: Adobe Acrobat Reader. Available via World Wide Web. / Abstract also in Chinese. Alzheimer's disease--Complications Muscle cells Gastrointestinal Motility Gastrointestinal Diseases Alzheimer Disease--complications Interstitial Cells of Cajal
2	Jugular venous reflux and white matter abnormalities in Alzheimer's disease: a pilot study Chung, C.P., Beggs, Clive B., Wang, P.N., Bergsland, N., Shepherd, Simon J., Cheng, C.Y., Ramasamy, D.P., Dwyer, Michael G., Hu, H.H., Zivadinov, R. January 2014 (has links) yes / To determine whether jugular venous reflux (JVR) is associated with cerebral white matter changes (WMCs) in individuals with Alzheimer's disease (AD), we studied 12 AD patients 24 mild cognitive impairment (MCI) patients, and 17 elderly age- and gender-matched controls. Duplex ultrasonography and 1.5T MRI scanning was applied to quantify cerebral WMCs [T2 white matter (WM) lesion and dirty-appearing-white-matter (DAWM)]. Subjects with severe JVR had more frequently hypertension (p = 0.044), more severe WMC, including increased total (p = 0.047) and periventricular DAWM volumes (p = 0.008), and a trend for increased cerebrospinal fluid volumes (p = 0.067) compared with the other groups. A significantly decreased (65.8%) periventricular DAWM volume (p = 0.01) in the JVR-positive AD individuals compared with their JVR-negative counterparts was detected. There was a trend for increased periventricular and subcortical T2 WMC lesion volumes in the JVR-positive AD individuals compared with their JVR-negative counterparts (p = 0.073). This phenomenon was not observed in either the control or MCI groups. In multiple regression analysis, the increased periventricular WMC lesion volume and decreased DAWM volume resulted in 85.7% sensitivity and 80% specificity for distinguishing between JVR-positive and JVR-negative AD patients. These JVR-WMC association patterns were not seen in the control and MCI groups. Therefore, this pilot study suggests that there may be an association between JVR and WMCs in AD patients, implying that cerebral venous outflow impairment might play a role in the dynamics of WMCs formation in AD patients, particularly in the periventricular regions. Further longitudinal studies are needed to confirm and validate our findings. Aged Aged, 80 and over Alzheimer Disease, complications Case-Control Studies Female Humans Image Processing, Computer-Assisted Jugular Veins, pathology Leukoencephalopathies Magnetic Resonance Imaging Male Mental Status Schedule Middle Aged Mild Cognitive Impairment Pilot Projects Retrospective Studies Statistics, Nonparametric Taiwan Ultrasonography, Doppler, Duplex Alzheimer's disease Doppler ultrasonography Jugular veins Leukoaraiosis

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An investigation into gastric myoelectrical activity in response to drug treatment during ageing and in a mouse model of Alzheimer's disease. / CUHK electronic theses & dissertations collection

Jugular venous reflux and white matter abnormalities in Alzheimer's disease: a pilot study