Charles Tomlinson Griffes (1884-1920) is one of the most important American impressionists in the twentieth century. This study focuses on the piano solo work Roman Sketches (Op.7) which Griffes composed during 1915-16, and it is the most representative work in his impressionistic styles. This work includes four pieces, which are The White Peacock, Nightfall, The Fountain of the Acqua Paola, and Clouds. Griffes quoted the four poems as forwards from the poetry Sospiri di Roma of the Scottish poet William Sharp (1855-1905) which mainly described the natural scene. Griffes integrated many musical elements of the Impressionism in Roman Sketches, such as whole-tone scales, pentatonic scales and exoticism. The first chapter in this study introduces the life of Griffes and characteristics of his piano works, and also emphasizes about how his works were affected by impressionism. The second chapter contains the historical background and the harmonic and melodic materials in Roman Sketches. Interpretative point of view about literary connection between music content and the poetry of Sharp is also discussed in this chapter.