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  • About
  • The Global ETD Search service is a free service for researchers to find electronic theses and dissertations. This service is provided by the Networked Digital Library of Theses and Dissertations.
    Our metadata is collected from universities around the world. If you manage a university/consortium/country archive and want to be added, details can be found on the NDLTD website.
91

Arginine Synthesis in Humans

Tomlinson, Robert Christopher Kennedy 31 August 2011 (has links)
Arginine synthesis is a complex, age-dependant process involving multiple precursors and enzymes, and the interorgan transfer of substrates. The objectives of this thesis were to elucidate arginine synthesis from enteral precursors in newborn infants and in healthy adults using stable isotope methodology. In the first, of four studies, I validated the use of a non-invasive methodology using urinary amino acids for stable isotope studies of arginine synthesis and demonstrated a known, but under-recognised, problem with D-amino acid contamination of tracers. Implementing chiral chromatography, this issue was further investigated using samples from previous studies in our laboratory with several different isotopes. I demonstrated the novel finding that the impact of D-amino acids is dependent on the tracer used, and also on the age of the subject. In the second study, I used a multi-tracer design to assess arginine synthesis from enteral proline or glutamate in healthy preterm infants. Labeled arginine (M+2), proline (M+1) and glutamate (M+3) were given enterally to fifteen stable, growing preterm infants (gestational age at birth 30-35 weeks) at 1-3 weeks’ postnatal age. I found only arginine synthesis from proline, with no synthesis from glutamate. I conclude that enteral proline is the major contributor to arginine synthesis in vivo in human preterm infants. In the third study, I measured arginine synthesis from enteral proline in adults. I have demonstrated that enteral proline contributes significantly, ~25%, to newly synthesised arginine. In the fourth study, I used two glutamine tracers, 1-13C and 2-15N, to determine if glutamine is a carbon or nitrogen donor for arginine. I showed that enteral glutamine contributes ~50% of the carbon skeleton for arginine and that the 2-15N tracer significantly overestimates arginine synthesis, with the labeled N being transferred through transamination from pyrroline-5-carboxylate (to ornithine, rather than directly from glutamate to pyrroline-5-carboxylate. In conclusion, proline is the sole precursor for arginine in human neonates and combines with glutamaine as the dietary precusor in adults. As a precussor for arginine, though, glutamine’s main role is in provision of nitrogen independent of the carbon skeleton.
92

Amino acids as additives in copper electrodeposition.

Gale, Robert J., 1942- January 1972 (has links)
No description available.
93

Plasma amino acids in epilepsy

Aslam Janjua, Najma. January 1982 (has links)
No description available.
94

The determination of amino acids by spectral reflectance

Frei, Roland Walter January 1965 (has links)
Typescript. / Thesis (Ph. D.)--University of Hawaii, 1965. / Bibliography: leaves 114-122. / viii, 123 l illus., tables
95

The amino acid sequence of Leucaena glauca ferredoxin

Benson, Ann Marie January 1969 (has links)
Typescript. / Thesis (Ph. D.)--University of Hawaii, 1969. / Bibliography: leaves 148-154. / xii, 154 l illus
96

Interaction of amino acids and related compounds with neutral polyadenylic acid: a proton magnetic resonance study

Raszka, Matthew Joseph January 1971 (has links)
Typescript. / Thesis (Ph. D.)--University of Hawaii, 1971. / Bibliography: leaves 157-164. / xii, 164 l illus
97

Structure-function relationships of bolaamphiphilic peptides and peptide hybrids /

Martari, Marco. January 2006 (has links)
Thesis (Ph. D.)--University of Stellenbosch, 2006. / Includes bibliographical references. Also available via the Internet.
98

Regulation of NMDA receptor properties by amino acids and cations : a biochemical and electrophysiological study /

Liu, Yun. January 1900 (has links)
Diss. (sammanfattning) Stockholm : Karol. inst. / Härtill 7 uppsatser.
99

Erythrocyte amino acids in health and renal failure and their association to the IGF-I/IGFBP-1 axis /

Divino Filho, José Carolino, January 1900 (has links)
Diss. (sammanfattning) Stockholm : Karol. inst. / Härtill 5 uppsatser.
100

Sulfur amino acids and their metabolites in patients with renal failure : relation to nutritional status and cardiovascular disease /

Suliman, Mohamed Elsaeid M., January 1900 (has links)
Diss. (sammanfattning) Stockholm : Karol. inst., 2001. / Härtill 7 uppsatser.

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