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Physiological studies on gastrointestinal sensing of peptides and amino acids / ペプチドおよびアミノ酸の腸管受容に関する生理学的研究Nakato, Junya 26 March 2018 (has links)
京都大学 / 0048 / 新制・課程博士 / 博士(農学) / 甲第21148号 / 農博第2274号 / 新制||農||1058(附属図書館) / 学位論文||H30||N5122(農学部図書室) / 京都大学大学院農学研究科食品生物科学専攻 / (主査)教授 金本 龍平, 教授 保川 清, 教授 谷 史人 / 学位規則第4条第1項該当 / Doctor of Agricultural Science / Kyoto University / DGAM
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Japanese broth promotes gastric emptying and those who intake miso soup frequently have less epigastric symptoms / 日本食特有のだしは胃排出を促進し、味噌汁の摂取頻度の高い人では上部消化管症状が少ないMano, Fumika 23 January 2019 (has links)
京都大学 / 0048 / 新制・課程博士 / 博士(医学) / 甲第21450号 / 医博第4417号 / 新制||医||1032(附属図書館) / 京都大学大学院医学研究科医学専攻 / (主査)教授 木原 正博, 教授 福原 俊一, 教授 森田 智視 / 学位規則第4条第1項該当 / Doctor of Medical Science / Kyoto University / DFAM
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An Investigation of The Role of Amino Acids in Plant-Plant Parasitic Nematode Chemotaxis and InfestationFrey, Timothy S. January 2019 (has links)
No description available.
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Resolving the Limitations of Genetic Code Expansion Platforms:Grasso, Katherine Taylor January 2021 (has links)
Thesis advisor: Abhishek Chatterjee / Thesis advisor: Eranthie Weerapana / Over the past twenty years, the site-specific incorporation of unnatural amino acids (UAAs) into a target protein through genetic code expansion (GCE) has emerged as one of the foremost technologies to selectively modify proteins in their native cellular context. This technology relies on engineered aminoacyl-tRNA synthetase (aaRS)/tRNA pairs that are orthogonal to the host cells’ endogenous aaRS/tRNA pairs. Traditionally, scientists look towards evolutionarily distant domains of life to identify orthogonal aaRS/tRNA pairs that can be further engineered for GCE applications in the host system. For example, bacterial aaRS/tRNA pairs are used for GCE in eukaryotes. The directed evolution of orthogonal aaRS/tRNA pairs for eukaryotic GCE has been less fortuitous due to the cumbersome nature of established yeast-based selection platforms. Recently, our lab circumvented this platform-based limitation by developing “altered translational machinery” (ATM) Escherichia coli strains that enabled the directed evolution of bacterial aaRS/tRNA pairs for eukaryotic GCE applications. In the ATM-tyrosyl (ATMY) E. coli strain, reintroduction of the E. coli tyrosyl-tRNA (tRNAEcTyrCUA) as a nonsense suppressor led to cross-reactivity with the endogenous E. coli glutaminyl-tRNA synthetase (EcGlnRS), restricting the activity range of aaRSs that could be selected, ultimately diminishing the scope of incorporable UAAs. To recover the dynamic range of this platform, cross-reactivity of the tRNAEcTyrCUA was eliminated through directed evolution of the tRNA acceptor stem. This new, orthogonal tRNA revealed weak mutant aaRSs whose suppression efficiencies were boosted through additional rounds of directed evolution. Improved aaRS mutants exhibited higher solubility, thermal stability, and suppression efficiency than their predecessor. While the newly engineered, orthogonal tRNAEcTyrCUA gave access to novel aaRS/tRNA pairs for eukaryotic GCE, some notable UAAs were still missing that could be incorporated with the archaeal Methanococcus jannaschii tyrosyl-tRNA synthetase (MjTyrRS)/tRNA pair in bacteria. Following a systematic investigation into the discrepancy between the E. coli tyrosyl-tRNA synthetase (EcTyrRS)/tRNA and MjTyrRS/tRNA pairs, we found that it can be partially attributed to the low structural robustness of the EcTyrRS. This limitation was overcome by rationally designing chimeric TyrRSs composed of EcTyrRS and a structural homologue from the thermophilic bacterium Geobacillus stearothermophilus. The chimeric scaffolds demonstrated enhanced stability, activity, and resilience to destabilizing active site mutations, offering a potentially more attractive scaffold for GCE. / Thesis (PhD) — Boston College, 2021. / Submitted to: Boston College. Graduate School of Arts and Sciences. / Discipline: Chemistry.
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The psychological effects of diet induced lowered tryptophan in normal human males /Smith, Scott E. (Scott Edward) January 1985 (has links)
No description available.
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Development of analytical techniques and mechanistic studies related to the thermal decomposition of Amadori rearrangement products from secondary aminesHuyghues-Despointes, Alexis January 1995 (has links)
No description available.
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The intracellular localization of holocarboxylase synthetase /Dumas, Richard. January 1999 (has links)
No description available.
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Molecular genetics of holocarboxylase synthetase deficiencyLéon Del Rio, Alfonso January 1995 (has links)
No description available.
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Comparisons of physiological amino acid levels for assessing dietary protein quality for swine.Boomgaardt, John. January 1969 (has links)
No description available.
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The lysinuric protein intolerance phenotype : amino acid transport in cultured skin fibroblastsSmith, Douglas W., 1961- January 1986 (has links)
No description available.
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