Global ETD Search

41	Age is a risk factor for Aβ₄₂ proteotoxicity in Drosophila melanogaster Vishnivetskaya, Anastasia January 2012 (has links) No description available. 576.5
42	Mutational analysis of the aggregation and toxicity of the amyloid beta peptide in a Drosophila model of Alzheimer's Disease Luheshi, Leila Mohamed January 2007 (has links) No description available. 540
43	The effects of a human b-amyloid gene on learning and memory in transgenic mice / / Effects of a human beta-amyloid gene on learning in transgenic mice Tirado Santiago, Giovanni January 1994 (has links) Brain deposition of the $ beta$-amyloid protein is an early marker of Alzheimer's disease (AD). AD is a neurodegenerative disorder characterized by learning and memory impairments. Here, mice (B6C3, 8 and 20 months old) transgenic for a human $ beta$-amyloid fragment were compared to normal litter mates in spatial and non-spatial learning tasks in the Morris water maze, according to standard procedures. Four measures of learning and performance were analyzed statistically: latency, total distance swam, mean distance to a platform, and number of trials correct in reaching a platform. Transgenic mice were impaired relative to their litter mates in spatial learning and performed better in the non-spatial task than in the spatial task in the first three measures. An age effect for transgenics was observed in the total distance measure. The results suggest that expression of the human $ beta$-amyloid protein may produce a selective learning deficit in mice. Amyloid beta-protein. Alzheimer's disease -- Animal models. Transgenic mice.
44	Molecular mechanisms in amyloid fibril formation / Hosia, Waltteri, January 2004 (has links) Diss. (sammanfattning) Stockholm : Karol. inst., 2004. / Härtill 5 uppsatser.
45	Functional domains in the Alzheimer's disease-associated presenilin 1 protein / Laudon, Hanna, January 2004 (has links) Diss. (sammanfattning) Stockholm : Karol. inst., 2004. / Härtill 4 uppsatser.
46	CPLA2 key enzyme for astrocytic cell membrane phase property change induced by abeta / Lai, Yinzhi. January 2007 (has links) Thesis (M.S.)--University of Missouri-Columbia, 2007. / The entire dissertation/thesis text is included in the research.pdf file; the official abstract appears in the short.pdf file (which also appears in the research.pdf); a non-technical general description, or public abstract, appears in the public.pdf file. Title from title screen of research.pdf file (viewed on April 14, 2008) Includes bibliographical references.
47	Characterization of hippocampal slice cultures as model systems for neurodegenerative processes in Alzheimer's disease / Johansson, Sara, January 2005 (has links) Diss. (sammanfattning) Stockholm : Karol. inst., 2005. / Härtill 4 uppsatser.
48	Regulation of the amyloid precursor protein (APP) gene promoter by hypoxia / Bielecki, Agnieszka. January 1900 (has links) Thesis (M.Sc.) - Carleton University, 2006. / Includes bibliographical references (p. 106-118). Also available in electronic format on the Internet.
49	Studying physiological functions of APP using mice models Li, Hongmei January 2008 (has links) Dissertation (Ph.D.) -- University of Texas Southwestern Medical Center at Dallas, 2008. / Vita. Bibliography: p. 97-121.
50	Alzheimer's disease (AD) like pathology following developmental lead exposure in primates and the role of aging in AD-related genes regulation in rodents and primates / Wu, Jinfang, January 2008 (has links) Thesis (Ph.D.) -- University of Rhode Island, 2008. / Typescript. Includes bibliographical references (leaves 141-159).

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