Made available in DSpace on 2014-12-17T14:16:23Z (GMT). No. of bitstreams: 1 DeboraAN.pdf: 367004 bytes, checksum: a62b214f06755ba9b9d2aedbea46c4f9 (MD5) Previous issue date: 2006-05-24 / This study aimed builds reference values for copper and zinc, of healthy adults in Natal-RN, and to identify the influence of the gender, age, body mass index (BMI) and diet, on those values. They were assessed 123 healthy students of the Universidade Federal do Rio Grande do Norte (UFRN), both genders, with age between 19 and 41 years. The project was approved by the Ethics Committee in Research of UFRN. BMI was determined and the food consume was accomplished through a 24h recordatory. Dietary was evaluated as the energy, macronutrients, copper and zinc, according to the recommendations of National Academy of Sciences (2001; 2002). Analyses of the copper and zinc concentrations in the plasma and erythrocytes were accomplished by flame atomic absorption spectrometry. The casuistic came quite homogeneous as for the distribution for gender and age, being the largest number of individuals between the 19 and 24 years old. Most of the volunteers presented anthropometric nutritional state inside of the normality patterns. Chronic diseases family antecedents and sedentarysm were observed. Diet was characterized with low consumption of zinc, appropriate of copper and of lipids. Average concentrations of plasma copper (p=0,002), erythrocyte copper (μg/dL, p=0,036; μg/gHb, p=0,038), and plasma zinc (p=0,022) were different among the genders, what was demonstrated by the largest values of copper in the female gender and larger of zinc in the masculine. Plasma copper values still suffered interference of the variables: energy, carbohydrate and copper consumption, all classified in agreement with the median, besides the protein classified according to the percentage contribution for the dietary total energy. The study allowed to establish reference values for erythrocyte zinc (1.261,6-1.344,0 μg/dL e 51,0-54,3 μg/gHb) and to suggest "indicative" of reference values for plasma (108,4 130,2 μg/dL) and erythrocyte (female = 85,0 91,4 μg/dL; masculine = 80,2 86,5 μg/dL) copper and plasma zinc (female = 98,8 105,8 μg/dL; masculine = 104,6 111,6 μg/dL) / O estudo teve como objetivo construir valores de refer?ncia para cobre e zinco, de adultos saud?veis na cidade do Natal-RN, e identificar a influ?ncia do g?nero, idade, ?ndice de massa corporal (IMC) e dieta, sobre esses valores. Foram avaliados 123 estudantes saud?veis da Universidade Federal do Rio Grande do Norte (UFRN), de ambos os g?neros, com idade entre 19 e 41 anos. O projeto foi aprovado pelo Comit? de ?tica em Pesquisa da UFRN. Foi estimado o indice de massa corporal e realizado um recordat?rio alimentar de 24h. A dieta foi avaliada quanto a energia, macronutrientes, cobre e zinco, segundo as recomenda??es da National Academy of Sciences (2001; 2002). As concentra??es de cobre e zinco no plasma e no eritr?cito foram realizadas por espectrofotometria de absor??o at?mica de chama. A casu?stica apresentou-se bastante homog?nea quanto ? distribui??o por g?nero e idade, estando o maior n?mero de indiv?duos entre os 19 e 24 anos. A maioria dos volunt?rios apresentou estado nutricional antropom?trico dentro dos padr?es de normalidade. Antecedentes familiares de doen?as cr?nicas e sedentarismo foram observados. A dieta caracterizou-se com baixo consumo de zinco, adequado de cobre e de lip?deos. As concentra??es m?dias de cobre no plasma (p=0,002), cobre no eritr?cito (μg/dL, p=0,036; μg/gHb, p=0,038), e zinco no plasma (p=0,022), foram estatisticamente diferentes entre os g?neros, o que foi demonstrado pelos maiores valores de cobre do g?nero feminino e maiores de zinco no masculino. Os valores de cobre no plasma sofreram ainda interfer?ncia das vari?veis: ingest?o de calorias, carboidrato e cobre na dieta, todos categorizados de acordo com a mediana, al?m da prote?na categorizada segundo o percentual de contribui??o para o valor cal?rico total (VCT) da dieta. O estudo permitiu estabelecer valores de refer?ncia para zinco no eritr?cito, correspondentes a 1.261,6-1.344,0 μg/dL e 51,0-54,3 μg/gHb, e sugerir indicativos de valores de refer?ncia para cobre no plasma (108,4 130,2 μg/dL), no eritr?cito (feminino = 85,0 91,4 μg/dL; masculino = 80,2 86,5 μg/dL) e zinco no plasma (feminino 98,8 105,8 = μg/dL; masculino 104,6 111,6 = μg/dL)