The metabolic and endocrine effects of anabolic compounds, viz., Zeranol, diethylstilbestrol (DES) and Synovex-S were investigated in growing steers in order to understand their biochemical mechanisms of action. The growth promoting properties of certain anabolic compounds were established. A marked reduction in the plasma concentration of urea nitrogen, alpha amino nitrogen and amino acids was found in steers implanted with anabolic compounds. The results suggested that anabolic compounds significantly alter the nitrogen metabolism of steers by increasing the efficiency of utilization of absorbed nitrogenous compounds. Implantations of DES and Synovex-S were more effective than Zeranol in enhancing the growth rate and altering the nitrogen metabolism of the animals. The usefulness of measuring NT-methylhistidine in urine as a non-destructive, in vivo index of myofibrillar protein degradation and the developmental aspects of muscle protein metabolism in cattle were demonstrated. The implantation of anabolic compounds, in general, increased the efficiency of muscle protein synthesized and protein deposited by the steers. Implantations of DES and Synovex-S were more effective than Zeranol due to a reduction in the muscle protein degradation per unit synthesized. Hydroxyproline excretion in the urine was used as an in vivo indicator of collagen turnover in steers. As the animals gained weight and advanced in maturity, its excretion in the urine decreased indicating a reduction in collagen turnover. Implantation of DES increased the hydroxyproline excreted by steers, while, Zeranol and Synovex-S had very little effect. These results indicate that DES implantation increases the amount of collagen and its turnover in steers. DES and Synovex-S exerted a significant influence on the activity of the thyroid gland and caused an elevation in the circulating concentrations of free and total thyroxine. On the other hand, the implantation of Zeranol resulted in plasma thyroxine concentrations similar to or lower than in the controls. Plasma triiodothyronine concentrations were not influenced by any of the compounds studied. Increased plasma thyroxine concentration observed in the DES or Synovex-S implanted steers was shown to be due to an increase in the secretion and a decrease in the metabolic clearance rates of thyroxine. The implantation of Zeranol appeared to increase the secretion rate of thyroxine, and resulted in slightly depressed plasma thyroxine concentration due to a higher metabolic clearance rate. Implantations of anabolic compounds resulted in an increase in the circulating concentration of growth hormone. Implantations of DES and Synovex-S were more effective than Zeranol in increasing the plasma growth hormone concentration. The kinetic parameters of growth hormone metabolism in growing steers were determined. The anabolic compounds increased the secretion rate of growth hormone from the pituitary gland suggesting that these compounds evoke growth promotion in steers through changes in the endogenous growth hormone status. These changes involved an increased secretion rate of growth hormone with very little alteration in the metabolic clearance rate. The metabolism of insulin was influenced to a significant extent in steers implanted with anabolic compounds. Zeranol increased the insulin secretion rate to a greater extent than Synovex-S or DES. The data indicated that the implantation of anabolic compounds altered the metabolism of steers significantly and enhanced the secretion rate of thyroxine, growth hormone and insulin. They altered the metabolism of the steers in such a way that there was an efficient utilization of absorbed nutrients. The mechanisms of action of anabolic compounds have been discussed in detail and the directions for future research suggested. / Land and Food Systems, Faculty of / Graduate

Diss. (sammanfattning) Stockholm : Karol. inst. / Härtill 6 uppsatser.

Thesis (M.S. in psychology)--Washington State University, May 2010. / Title from PDF title page (viewed on May 3, 2010). "Department of Psychology." Includes bibliographical references (p. 32-43).

Diss. (sammanfattning) Uppsala : Uppsala universitet, 2005. / Härtill 5 uppsatser.

Thesis (Ph. D.)--Louisiana State University, Baton Rouge, 2008. / Title from document title page.

No description available.

Thesis (M.S.)--Virginia Polytechnic Institute and State University, 1992. / Vita. Abstract. Includes bibliographical references (leaves 57-62). Also available via the Internet.

My diploma thesis deals with doping and is specially focused on anabolic steroids. It was written in response to § 288 Criminal code, which newly describes production and other handling with hormonal effect as a delict in order to reduce the number of users, both among proffesional and among recreational sportsmen. It shows that sport federations have enough instruments to be able to face doping and that the newly adopted legal ragulation has a negative impact on human health, which is inconsistent with the reasons for which it was adopted.

Young female rats treated with trenbolone demonstrated an increase in weight gain per day and overall weight increase during the treatment period. Trenbolone treated rats also experienced improved feed efficiency. Muscles removed from the lower hind limb of trenbolone treated rats had a greater DNA to protein ratio than muscles from control animals. However, there was no significant difference in wet muscle weight between trenbolone treated and control muscles. Satellite cells from untreated female rats were not responsive to trenbolone added in vitro. In studies utilizing serum free medium, trenbolone alone, and in the presence of growth factors, could not stimulate proliferation above controls. In similar serum free medium studies, satellite cells from trenbolone treated rats were more responsive to growth factors than cells from control rats.

Orientador: Oduvaldo Câmara Marques Pereira / Banca: Débora Cristina Damasceno / Banca: Maeli Dal Pai Silva / Banca: Daniela Cristina Ceccatto Gerardin / Banca: Patrícia Carvalho Garcia / Resumo: Considerando-se a importância do exercício físico para a prevenção de problemas na saúde de indivíduos adultos e idosos associada à procura pela melhor forma de se exercitar, tem aumentado a busca por ergogênicos nos dias de hoje. Assim, os ergogênicos têm sido apontados como as principais substâncias utilizadas em tratamentos para o retardo da velhice e prevenção de doenças como enfarte e osteoporose. Porém pouco se sabe sobre o melhor método para estes tratamentos. Logo, o objetivo do presente trabalho foi determinar os efeitos produzidos pelo treinamento resistido de alta intensidade e/ou tratamento com decanoato de nandrolona (anabolizante esteróide) sobre os aspectos sociais e reprodutivos, e à resistência mecânica do fêmur em ratos machos. Os ratos foram divididos em seis grupos experimentais: controle não treinado, controle treinado, anabolizante treinado, anabolizante não treinado, controle treinado pirâmide e anabolizante treinado pirâmide. O programa de exercício foi realizado três dias por semana, durante 8 semanas. Concomitantemente, o tratamento com o anabolizante esteróide - decanoato de nandrolona - foi realizado duas vezes por semana e ao final deste treinamento os ratos foram submetidos a um teste de agressividade (comportamento social) e a seguir eutanasiados. Foram realizadas análises ósseas (cabeça do fêmur), atividade da creatina kinase (CK), contagem espermática e viabilidade dos espermatozóides ao final das 8 semanas, com exceção a mensuração da CK que foi realizada ao longo do treinamento pirâmide. Os grupos submetidos ao exercício foram subdivididos para a realização de um protocolo de treinamento chamado "pirâmide". Neste treinamento, os ratos foram submetidos a uma série de repetições máximas, na qual foi testada sua resistência à fadiga, de grande importância para avaliarmos o dano ou fortalecimento ósseo, assim... (Resumo completo, clicar acesso eletrônico abaixo) / Abstract: Considering the importance of physical exercise in the prevention of several health diseases on adults and elderly, searching the best way of exercise, the sought for ergogenics has increased nowadays. On this sense, ergogenics have been pointed as one of the most utilized substances on the treatment of aging, prevention of heart attack and osteoporosis. However, little is known about the best method to these treatments. Therefore, the aim of the present study was to determine the effects produced by the high intensity resistance exercise and/or treatment with nandrolone (anabolic steroid) on social and reproductive aspects, as well as, the bone mechanical resistance on adult male rats. The rats were divided into six experimental groups: Untrained/Vehicle, Untrained/Anabolic, Trained/Vehicle, Trained/Anabolic, Pyramid/Vehicle and Pyramid Anabolic. The exercise protocol was performed three times a week, one day a part, during 8 weeks. The treatment with the anabolic steroid was realized within the eight weeks and at the end of the treatment/training, the animals were euthanized and the following analyses were assessed: femur mechanical resistance, creatine kinase (CK) activity, sperm count and seminal parameters, hormonal levels and the aggressive behavior. For the aggressive behavior the animals were isolated, and only the treatment was performed. The CK activity was the only measurement assessed during the 8 weeks. The groups submitted to the exercise were subdivided on the sixth week to accomplish another exercise protocol, known as pyramid training. This training protocol associates increasing working loads with low repetitions during the program, in which we tested the fatigue resistance, extremely important to evaluate the damage on bone strength, as well as other alterations. Through this analysis we could observe that the rats treated with decanoate... (Complete abstract click electronic access below) / Doutor