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  • About
  • The Global ETD Search service is a free service for researchers to find electronic theses and dissertations. This service is provided by the Networked Digital Library of Theses and Dissertations.
    Our metadata is collected from universities around the world. If you manage a university/consortium/country archive and want to be added, details can be found on the NDLTD website.
1

Endosomal regulation of DAF-16FOXO transcription factors by the insulin signaling pathway in «Caenorhabditis elegans»

Meras, Icten January 2018 (has links)
No description available.
2

Changes in synaptic connectivity during ultradian growth hormone secretion are correlated with changes in astrocytic coverage of neurons as seen in super-resolution and electron microscopy

Bednarz, Klaudia January 2019 (has links)
No description available.
3

Characterization of CdGAP/ARHGAP31 as a novel biological target in prostate cancer

Mehra, Chahat January 2019 (has links)
No description available.
4

Elucidating tau-mediated neurodegeneration, inflammation and vasculopathy: insights into tauopathies gained by a novel transgenic rat model

Malcolm, Janice January 2020 (has links)
No description available.
5

Characterizing the telomerase-associated and H/ACA ribonucleoprotein dyskerin: regulation and function

MacNeil, Deanna January 2020 (has links)
No description available.
6

The cloning and characterisation of the chicken tyrosinase-related protein gene family

April, Craig Stuart January 1998 (has links)
Very little is known about the molecular and genetic mechanisms controlling pigmentation within the bird kingdom. The aim therefore, of this study was to contribute towards the understanding of the genetic regulation of avian pigmentation by the cloning and characterisation of the chicken Tyrosinase-related protein (TRP) gene family. To accomplish this goal, neural crest cells from 500 black chick embryos were cultured under conditions supportive of melanocyte differentiation and proliferation. Using RNA extracted from these pigmented melanocyte cultures, a novel embryonic chick cDNA library was constructed. Screening of this library for chicken equivalents of the mammalian TRP gene family yielded more than 200 cDNA clones. After sequencing, three of these clones, 88.3, pcTRP- 1.6 and pcTRP -2. 10, were found to encode chicken Tyrosinase (Tyr), Tyrosinase-related protein-1 (Tyrp1) and Tyrosinase-related protein-2 (Tyrp2), respectively. In addition, a chicken Microphthalmia (Mi) cDNA clone (M156) was isolated using a mouse Mi cDNA probe. Comparative analyses revealed that chicken Tyr, Tyrp1 and Tyrp2 share approximately 68%, 72% and 70% amino acid sequence identity with their vertebrate orthologues. Northern blot hybridisation analysis demonstrated that the chicken TRPs are expressed in RNA from cultured retinal pigment epithelial (RPE) cells as well as in whole eye RNA. The major transcript sizes for the chicken Tyr, Tyrp1 and Tyrp2 genes are 2.5 kb, 2.3 kb and 3.5 kb, respectively. In situ hybridisation studies confirmed that both chicken Tyr and Tyrp2 genes are expressed in a pigment cell-specific fashion with signals detected in both the skin and RPE of chick embryos. Genomic Southern blot hybridisation analyses strongly suggested that all three chicken TRP genes contain several introns that are likely to be conserved within the vertebrate TRP gene family. Furthermore, the chick Tyr, Tyrp1 and Tyrp2 genes were found to span approximately 5-19 kb, 5-11 kb and 15-30 kb, respectively of the chicken genome. Comparisons between a black and white chick breed at the Tyr and Tyrp1 loci revealed no gross rearrangements at either of these loci. However, 1-2 kb alterations were observed between the same breeds at the Tyrp2 locus. The nature and significance of this alteration is not known. The cloning of the chicken Tyr, Tyrp1 and Tyrp2 cDNAs constitutes the first molecular cloning and characterisation of any avian TRP gene family. Taken together therefore, this study contributes towards the further understanding of the molecular mechanisms regulating pigmentation as well as the evolution of gene families.
7

Exploring mitochondrial fusion mechanism in mammals

Chen, Yiyang January 2019 (has links)
No description available.
8

Doublet microtubule inner proteins exhibit a stabilizing and regulatory role in the ciliary axoneme

Khalifa, Ahmad January 2020 (has links)
No description available.
9

Characterizing novel Rho GTPase effectors and signalling pathways by BioID-proteomics

Bagci, Halil January 2019 (has links)
No description available.
10

Synaptic dysfunction in lysosomal storage disorders: pathogenic mechanism and potential therapeutic applications

De Britto Pará De Aragão, Camila January 2020 (has links)
No description available.

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