Spelling suggestions: "subject:"androgens receptors"" "subject:"androgen's receptors""
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Androgen receptor mutation in breast cancerElhaji, Youssef A. January 1997 (has links)
Normal breast growth and development depends on functional androgen:estrogen (A:E) balance. Androgen actions are mediated by the androgen receptor (AR), a DNA-binding, transcriptional-regulatory protein. Decreased AR transactivational. activity lowers A:E balance and may result in functional hyperestrogenicity: this could promote the pathogenesis of breast cancer (BC). The present study is the first to seek AR mutations in female BC. The length of the polymorphic CAG-repeat in exon 1 of the AR correlates inversely with the transactivational activity of the AR. Using 10% polyacrylamide gels, I found a significant (p < 0.0001) shift to greater CAG-repeat lengths in BC samples. This suggests a role for ARs with long polyglutamine tracts in the initiation and/or progression of BC. Exons 2--8 of the AR in 81 fresh frozen BC tumor tissues were screened for mutations using SSCP analysis. I did not detect any mutations in these exons.
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Observations on the association of androgen-receptor complexes with the nuclear matrix of human genital skin fibroblastsPincott, Cynthia January 1987 (has links)
No description available.
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Observations on the association of androgen-receptor complexes with the nuclear matrix of human genital skin fibroblastsPincott, Cynthia January 1987 (has links)
No description available.
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Androgen receptor mutation in breast cancerElhaji, Youssef A. January 1997 (has links)
No description available.
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Novel androgen receptor-protein interactions as possible contributors to the pathogenesis of spinal and bulbar muscular atrophyDe Tourreil, Sunita. January 1997 (has links)
The human androgen receptor (hAR) is a ligand-activated, DNA-binding nuclear transcription factor. Mutations in the hAR result in varying degrees of androgen insensitivity (AI); they may play a predisposing or pathogenetic role in both prostate and breast cancer. Expansion of the hAR's N-terminal polymorphic Glutamine (Gln) repeat causes a late-onset progressive motoneuronopathy which is associated with mild androgen insensitivity: spinal and bulbar muscular atrophy (SBMA). SBMA belongs to a group of translated CAG trinucleotide repeat expansion neuronopathies that includes Huntington disease, dentatorubral-pallidoluysian atrophy and five distinct spinocerebellar ataxias. The fact that this group of disorders is caused by polyGln expansions in totally unrelated proteins, is one of the main reasons for postulating that a common gain-of-function mechanism must underlie their communal pathogenesis. This common pathogenetic mechanism is postulated to occur via aberrant protein interactions. / I undertook a search for hAR-interacting proteins using a yeast two-hybrid system. A human testes cDNA library was screened several times with two forms of an N-terminal fragment of the hAR: a normal (20 Gin) hAR and an expanded (50 Gin) hAR. A few candidate hAR-interacting proteins were isolated during the library screenings and I tested them for physiological relevance. / A second aspect of my project included the analysis of an aberrant 75-kD protein fragment generated in COS-1 cells transfected with a polyCAG-expanded (n = 44) hAR cDNA. Recent work in Huntington disease and spinocerebellar ataxia type 3 shows the accumulation of insoluble protein aggregates primarily in the nucleus of certain brain cells (Davies et al., 1997; Scherzinger et al., 1997; Paulson et al., 1997). I confirmed the presence of the aberrant hAR-fragment in the nucleus through western analysis of protein samples extracted from the nucleus.
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Targeting the androgen receptor as a therapeutic strategy for prostate cancer.Marrocco, Deborah Lydia January 2006 (has links)
Title page, contents and abstract only. The complete thesis in print form is available from the University of Adelaide Library. / "The objectives of this thesis were to characterise the effects fo AR-targeting agents on the growth of prostate cancer cells and to determine whether combining these agents to target the AR (androgen receptor) at more than one level in the signalling pathway would provide a more complete block of androgen signalling and prostate cancer cell growth." --p. v. / http://proxy.library.adelaide.edu.au/login?url= http://library.adelaide.edu.au/cgi-bin/Pwebrecon.cgi?BBID=1289482 / Thesis (Ph.D.) -- University of Adelaide, School of Medicine,2006
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Targeting the androgen receptor as a therapeutic strategy for prostate cancer.Marrocco, Deborah Lydia January 2006 (has links)
Title page, contents and abstract only. The complete thesis in print form is available from the University of Adelaide Library. / "The objectives of this thesis were to characterise the effects fo AR-targeting agents on the growth of prostate cancer cells and to determine whether combining these agents to target the AR (androgen receptor) at more than one level in the signalling pathway would provide a more complete block of androgen signalling and prostate cancer cell growth." --p. v. / http://proxy.library.adelaide.edu.au/login?url= http://library.adelaide.edu.au/cgi-bin/Pwebrecon.cgi?BBID=1289482 / Thesis (Ph.D.) -- University of Adelaide, School of Medicine,2006
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Normal and mutant regulation of androgen receptor activity in human genital skin fibroblastsHollander, Ricki. January 1981 (has links)
Note:
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Novel androgen receptor-protein interactions as possible contributors to the pathogenesis of spinal and bulbar muscular atrophyDe Tourreil, Sunita. January 1997 (has links)
No description available.
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Neuroanatomical distribution of androgen and estrogen receptors in the brain of the roughskin newt, Taricha granulosaDavis, Glen Andrew 07 December 1994 (has links)
The gonadal steroids, testosterone and estradiol, are known to be important
modulators of neuronal functions and behaviors in most vertebrate species. These
steroid hormones also elicit changes in neuropeptide synthesis and secretion, alter
specific neurohormone receptor levels, and alter neuronal morphology and
electrophysiology. Many of the actions of androgens and estrogen are mediated by
specific intracellular receptors found in certain regions of the brain. But where are
these neuronal targets for androgens and estrogen found?
The research in this thesis investigates the neuroanatomical distribution of
androgen and estrogen receptors in the brain of a urodele amphibian, the roughskin
newt, Taricha granulosa. Using immunocytochemistry with antibodies against these
receptors, the distribution of both androgen and estrogen receptor-immunoreactive
cells is described in the brain of this species. This study found brain regions that
contain immunoreactive androgen receptors that have not previously been reported in
poikilothermic vertebrates using other techniques.
In addition, the distribution of estrogen receptor-immunoreactive cells in
most brain areas, and the distribution of androgen receptor-immunoreactive cells in
several brain areas, were found to be similar in this amphibian to those described in
studies that employed in vivo autoradiographic techniques in other vertebrate species.
This study suggests that the neuroanatomical distribution of gonadal steroid receptors
is a relatively conserved trait in vertebrates. The widespread distribution of these
receptors in the brain probably reflects the multiple functions that androgens and
estrogen are known to have in the brain. / Graduation date: 1995
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