Made available in DSpace on 2014-12-17T15:42:21Z (GMT). No. of bitstreams: 1 MarciaLS_DISSERT.pdf: 3817212 bytes, checksum: 089f2e43de0c72515df1302d1f7136f9 (MD5) Previous issue date: 2014-08-19 / Coordena??o de Aperfei?oamento de Pessoal de N?vel Superior / This study used the Thermogravimetry (TG) and molecular absorption spectroscopy in UV-visible region to determine the iron content in herbal medicinal ferrous sulfate used in the treatment of iron deficiency anemia. The samples were characterized by IR, UV, TG / DTG, DTA, DSC and XRD. The thermoanalytical techniques evaluated the thermal stability and physicochemical events and showed that the excipients interfere in the decomposition of the active ingredients. The results of thermogravimetry showed that the decomposition temperature of the active principle Fe2(SO4)3 (T = 602 ?C) is higher as compared to samples of tablets (566 586 ?C). In the DTA and DSC curves were observed exothermic and endo events for samples of medicines and active analysis. The infrared spectra identified key functional groups exist in all samples of active ingredients, excipients and compressed studied, such as symmetric and asymmetric stretching of OH, CH, S=O. The analysis by X-ray diffraction showed that all samples had crystallinity and the final residue showed peaks indicating the presence of silicon dioxide, titanium dioxide and talc that are excipients contained in pharmaceutical formulations in addition to iron oxide. The results obtained by TG to determine the iron content of the studied drugs showed a variance when compared with those obtained by theoretical and UV-visible, probably due to formation of a mixture of Fe2O3 and Fe2(SO4)3. In one tablet was obtained FE content of 15.7 % and 20.6 % for TG by UV-visible, the sample EF 2 was obtained as a percentage of 15.4 % and 21.0 % for TG by UV-visible . In the third SF samples were obtained a content of 16.1 % and 25.5 % in TG by UV-visible, and SF 4 in the percentage of TG was 16.7 % and 14.3 % UV-visible / O presente trabalho utilizou a termogravimetria (TG) e a espectroscopia de absor??o molecular na regi?o UV-vis?vel para determinar o teor de ferro em medicamentos ? base de sulfato ferroso usados no tratamento da anemia ferropriva. As amostras foram caracterizadas por IV, UV, TG/DTG, DTA, DSC e DRX. As t?cnicas termoanal?ticas avaliaram a estabilidade t?rmica e os eventos f?sico-qu?micos e mostraram que os excipientes interferem na decomposi??o do princ?pio ativo. Os resultados da Termogravimetria indicaram que a temperatura de decomposi??o do Fe2(SO4)3 (T = 602 ?C) ? superior em compara??o as amostras dos comprimidos (566 a 586 ?C). Nas curvas DTA e DSC foram observados eventos endo e exot?rmicos para as amostras dos medicamentos e princ?pio ativo analisado. Os espectros de infravermelho identificaram os principais grupos funcionais existentes em todas as amostras de princ?pios ativos, excipientes e comprimidos estudados, tais como estiramentos sim?tricos e assim?tricos dos grupos O-H, C-H, S=O. As an?lises por difra??o de raios- X mostraram que todas as amostras apresentaram cristalinidade e que os res?duos finais mostraram picos indicativos da presen?a de di?xido de sil?cio, di?xido de tit?nio e talco que s?o excipientes contidos nas formula??es farmac?uticas, al?m do ?xido de ferro. Os resultados obtidos por TG para determinar o teor de ferro dos medicamentos estudados mostraram uma varia??o quando comparados aos obtidos pelo UV-vis?vel e o te?rico, provavelmente devido a forma??o de uma mistura de Fe2O3 e Fe2(SO4)3. No comprimido FE 1 foi obtido um teor de 15,7 % pela TG e 20,6 % pelo UV-vis?vel, na amostra FE 2 obteve-se um percentual de 15,4 % pela TG e 21,0 % pelo UV-vis?vel. Nas amostras FE 3 obteve-se um teor de 16,1 % na TG e 25,5 % pelo UV-vis?vel, e em FE 4 o percentual na TG foi de 16,7 % e no UV-vis?vel 14,3 %