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Impact of Dietary Arginine on Immunity in Broiler ChicksD'amato, Jennifer Lynn 01 October 2009 (has links) (PDF)
Arginine (ARG) is an immunologic modulator due in part to its role as a substrate for leukocytes. Therefore, the objective of these studies was to evaluate the impact of dietary ARG on ARG utilization in peripheral blood mononuclear cells (PBMC) and thymocytes in broiler chicks as they provide a model that is not confounded by de novo ARG synthesis. Several experiments were performed to measure: 1) ARG transporters as markers of ARG utilization by leukocytes; 2) thymocyte proliferation; 3) PBMC phenotype, and 4) ARG’s impact on the acute phase response (APR). In experiment 1, chicks were fed diets containing 1.20% or 1.35% dietary ARG. On d7, PBMC CAT-1 mRNA abundance was 2-fold higher in chicks fed 1.35% ARG than in those fed 1.20% ARG (P<0.05). Between d3 and d14, 1.20% ARG increased thymocyte y+LAT-2 mRNA abundance 2.5-fold (P<0.05) while 1.35% ARG did not. In experiments 2 and 3, chicks were fed diets containing 1.1%, 1.3%, and 1.5% dietary ARG. On d10, 1.5% ARG reduced thymocyte proliferation compared to 1.1% and 1.3% ARG (P<0.05). The percentage of peripheral blood B cells tended (P=0.06) to have an age by ARG interaction. On d14, but not on d10 or 17, the percentage of monocytes from chicks fed 1.5% was higher than from those fed 1.1% and 1.3% ARG (P<0.05). In experiment 3, chicks from four replicate pens per treatment were not injected (control) or injected subcutaneously with Salmonella typhimurium lipopolysaccharide (LPS; 1 mg/kg BW) to initiate the APR. At 2 h post LPS injection, there tended (P=0.08) to be a LPS by ARG interaction for TGF-β4 mRNA abundance. Therefore, these studies indicate that the optimal level of dietary ARG supplementation for utilization by ARG transporters in leukocytes is higher than what is sufficient for growth and is both age and leukocyte dependent. Additionally, these studies indicate that dietary ARG levels above the NRC requirement may be beneficial for the abundance of PBMC sub-populations. These studies also indicate that the APR may be manipulated by dietary ARG.
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Effects of American fruit extracts on antioxidant-related genes in cultured cells & on modulation of metabolomic profile in poultrySienkiewicz, Olimpia January 2022 (has links)
No description available.
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Monkey see monkey do? Evaluating the use of caregiver behaviours as social enrichment for captive rhesus and cynomolgus macaquesVan Vliet, Rachel January 2022 (has links)
No description available.
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Assessing the Impacts of Environmental Changes on the Welfare of Ambassador African Penguins (Spheniscus demersus)England, Zachary January 2021 (has links)
No description available.
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An examination of the genetic diversity of the major histocompatibility complex in commercial and domestic chicken breedsDarrington, Corie January 2023 (has links)
No description available.
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Effect of intramammary infusion of chitosan hydrogels on bovine mammary gland involution after drying-offLanctôt, Samuel January 2017 (has links)
No description available.
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Profitability analyses of Québec dairy cattle using health and management data via visualization tools.Delgado Rodriguez, Hector January 2016 (has links)
No description available.
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Investigating the role of ERK1/2 pathway in the functional localization and action of NR5A2 in murine granulosa cells during ovulationTaibi, Milena January 2017 (has links)
No description available.
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Evaluation of various strategies to accelerate mammary gland involution at drying-off and study of the prolactin secretion regulation by glucocorticoidsPonchon, Benjamin January 2016 (has links)
No description available.
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The effect of age and gonadotropin stimulation on the embryo development of Holstein heifer calf oocytesCurrin, Luke January 2017 (has links)
No description available.
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