by Chiu-lun Fok. / Thesis (M.Phil.)--Chinese University of Hong Kong, 1991. / Includes bibliographical references. / List of Abbreviations --- p.i / Abstract --- p.iii / Chapter Chapter 1 --- Introduction --- p.1 / Chapter 1.1 --- General Properties of Oxalysine --- p.1 / Chapter 1.1.1 --- Chemical Structure and Properties --- p.1 / Chapter 1.1.2 --- Biological Properties --- p.2 / Chapter 1.1.2.1 --- Antimicrobial Activity --- p.2 / Chapter 1.1.2.2 --- Antitumor Activity --- p.2 / Chapter 1.1.2.3 --- Immunomodulatory Activity --- p.5 / Chapter 1.1.2.4 --- Other Biological Properties --- p.5 / Chapter 1.1.3 --- Pharmacokinetics and Toxicity --- p.6 / Chapter 1.2 --- General Properties of Ribosome-Inactivating and Abortifacient Proteins --- p.8 / Chapter 1.2.1 --- Research History --- p.8 / Chapter 1.2.1.1 --- Ribosome-Inactivating Proteins --- p.8 / Chapter 1.2.1.2 --- Abortifacient Proteins --- p.9 / Chapter 1.2.2 --- Relationship between Ribosome- Inactivating Proteins and Abortifacient Proteins --- p.10 / Chapter 1.2.3 --- Distribution --- p.11 / Chapter 1.2.4 --- Physicochemical Characteristics --- p.12 / Chapter 1.2.5 --- Biological Properties --- p.13 / Chapter 1.2.5.1 --- Effect on Protein Synthesis --- p.13 / Chapter 1.2.5.2 --- Effect on the Immune System --- p.14 / Chapter 1.2.5.3 --- Cytotoxic and Antitumor Activities --- p.16 / Chapter 1.2.5.4 --- Termination of Pregnancy --- p.17 / Chapter 1.2.5.5 --- Antiviral Activity --- p.18 / Chapter 1.2.6 --- The Study on Luffaculin --- p.19 / Chapter 1.3 --- Aim of the Present Study --- p.20 / Chapter 1.3.1 --- Oxalysine --- p.20 / Chapter 1.3.2 --- Luffaculin --- p.20 / Chapter Chapter 2 --- Materials and Methods --- p.22 / Chapter 2.1 --- Materials --- p.22 / Chapter 2.2 --- Methods --- p.30 / Chapter 2.2.1 --- In Vivo Drug Treatment --- p.30 / Chapter 2.2.2 --- Isolation and Preparation of Cells --- p.30 / Chapter 2.2.2.1 --- Peritoneal Exudate Cells --- p.30 / Chapter 2.2.2.2 --- Spleen Cells --- p.30 / Chapter 2.2.2.3 --- Ficoll-Paque Separation of Lymphocytes --- p.31 / Chapter 2.2.2.4 --- Congo Red-Stained Yeast Cells --- p.31 / Chapter 2.2.3 --- Lymphocyte Transformation --- p.32 / Chapter 2.2.4 --- Haemolytic Plaque Assay --- p.33 / Chapter 2.2.5 --- Phagocytic Activity --- p.33 / Chapter 2.2.6 --- Macrophage-Mediated Cytostatic Activity --- p.34 / Chapter 2.2.7 --- Delayed Type Hypersensitivity (DTH) --- p.35 / Chapter 2.2.8 --- Production of and Assay for Interleukin-2(IL-2) --- p.36 / Chapter 2.2.9 --- Cytotoxicity of the Drugs on Various Cell Lines --- p.38 / Chapter 2.2.9.1 --- Trypan Blue Exclusion Method --- p.38 / Chapter 2.2.9.2 --- Neutral Red Uptake Method --- p.38 / Chapter 2.2.10 --- Cytostatic Effect of the Drugs on Various Cell Lines --- p.39 / Chapter 2.2.11 --- Evaluation of Antitumor Activity (In Vivo ) --- p.40 / Chapter 2.2.11.1 --- Tumor Size --- p.40 / Chapter 2.2.11.2 --- Survival Study --- p.40 / Chapter 2.2.12 --- TLC Analysis --- p.40 / Chapter 2.2.13 --- Preparation of Ribosome-Inactivating and Abortifacient Proteins --- p.41 / Chapter 2.2.13.1 --- Trichosanthin (TCS) --- p.41 / Chapter 2.2.13.2 --- Luffaculin (LFC) --- p.42 / Chapter 2.2.14 --- Protein Determination --- p.42 / Chapter 2.2.15 --- Statistical Analysis --- p.43 / Chapter Chapter 3 --- The Immunomodulatory and Antitumor Activities of Oxalysine (OXL) --- p.44 / Chapter 3.1 --- Introduction --- p.44 / Chapter 3.2 --- The Immunomodulatory Activity of Oxalysine --- p.46 / Results --- p.46 / Chapter 3.2.1 --- Effect of Oxalysine on the Proliferation of Mouse Splenocytes --- p.46 / Chapter 3.2.2 --- Effect of In Vitro Oxalysine Exposure on the Response of Murine Splenocytes to Mitogens --- p.46 / Chapter 3.2.3 --- Effect of In Vivo Oxalysine Treatment on the Response of Murine Splenocytes to Mitogens --- p.49 / Chapter 3.2.4 --- Effect of Oxalysine on Delayed Type Hypersensitivity (DTH) Response --- p.51 / Chapter 3.2.5 --- Effect of Oxalysine on the In Vitro Phagocytic Activity of Mouse Peritoneal Macrophages --- p.51 / Chapter 3.2.6 --- Effect of Oxalysine on Macrophage- Mediated Cytostatic Activity --- p.53 / Chapter 3.2.7 --- Effect of Oxalysine on the Humoral Response to SRBC --- p.55 / Discussion --- p.59 / Chapter 3.3 --- Mechanistic Studies on Inhibition of Mitogen´ؤ Induced Lymphocyte Transformation by Oxalysine --- p.62 / Results --- p.62 / Chapter 3.3.1 --- Lack of Direct Cytotoxic Effect of Oxalysine on Mouse Splenocytes In Vitro --- p.62 / Chapter 3.3.2 --- Effect of Oxalysine on the Kinetics of Con A-Induced Lymphoproliferative Response --- p.62 / Chapter 3.3.3 --- Time Course Studies on the Effect of Oxalysine on Mitogen-Induced Lymphocyte Transformation --- p.64 / Chapter 3.3.3.1 --- Preincubation of Oxalysine --- p.64 / Chapter 3.3.3.2 --- Delayed Addition of Oxalysine --- p.67 / Chapter 3.3.4 --- Effect of Exogenous IL-2 on the Oxalysine-Mediated Suppression of Lymphocyte Blastogenesis --- p.69 / Chapter 3.3.5 --- Effect of Oxalysine on the Activity of IL-2 Containing Medium to Maintain the Proliferation of the IL´ؤ2 Dependent CTLL-2 Cells --- p.73 / Chapter 3.3.6 --- Production of IL-2 from Splenocytes of Oxalysine´ؤTreated Mice --- p.75 / Chapter 3.3.7 --- The In Vitro Effect of Oxalysine on the Production of IL-2 from Con A-Activated Mouse Splenocytes --- p.75 / Discussion --- p.79 / Chapter 3.4 --- The Antitumor Activity of Oxalysine --- p.83 / Results --- p.83 / Chapter 3.4.1 --- Cytotoxicity of Oxalysine on Various Tumor Cell Lines --- p.83 / Chapter 3.4.2 --- Cytostatic Effect of Oxalysine on Various Tumor Cell Lines --- p.85 / Chapter 3.4.3 --- Effect of Oxalysine on the Survival of Tumor-Bearing Mice --- p.93 / Chapter 3.4.4 --- Effect of Oxalysine on the Growth of Transplantable Tumor Cells In Vivo --- p.95 / Discussion --- p.100 / Chapter 3.5 --- General Discussion --- p.102 / Chapter Chapter 4 --- The Immunomodulatory and Cytotoxic Properties of Luffaculin (LFC) --- p.104 / Chapter 4.1 --- Introduction --- p.104 / Chapter 4.2 --- The Immunomodulatory Activity of Luffaculin --- p.106 / Results --- p.106 / Chapter 4.2.1 --- Lack of Direct Cytotoxic Effect of LFC on Mouse Splenocytes In Vitro --- p.106 / Chapter 4.2.2 --- Effect of Luffaculin on the Proliferation of Mouse Splenocytes --- p.108 / Chapter 4.2.3 --- Inhibition of the Mitogen-Induced Lymphocyte Transformation by Luffaculin --- p.108 / Chapter 4.2.4 --- Effect of Luffaculin on Delayed Type Hypersensitivity (DTH) Response --- p.114 / Chapter 4.2.5 --- Primary Humoral Immune Response to SRBC in Luffaculin-Treated Mice --- p.114 / Chapter 4.2.6 --- Effect of Luffaculin on Phagocytosis of Macrophages In Vitro --- p.117 / Chapter 4.2.7 --- Effect of Luffaculin on Macrophage- Mediated Cytostatic Activity --- p.117 / Chapter 4.2.8 --- Production of Interleukin´ؤ2 from Splenocytes of Luffaculin-Treated Mice --- p.119 / Discussion --- p.122 / Chapter 4.3 --- The Cytotoxic and Cytostatic Effects of Luffaculin on Various Tumor Cell Lines --- p.125 / Results --- p.125 / Chapter 4.3.1 --- Cytotoxicity of Luffaculin on Various Tumor Cell Lines --- p.125 / Chapter 4.3.2 --- Cytostatic Effect of Luffaculin on Various Tumor Cell Lines --- p.127 / Discussion --- p.138 / Chapter 4.4 --- General Discussion --- p.140 / References --- p.143

by Sze Shun Fai. / Thesis (M.Phil.)--Chinese University of Hong Kong, 1992. / Includes bibliographical references (leaves 132-139). / Abstract --- p.1 / Chapter Chapter 1 --- General Introduction / Chapter 1.1 --- The pineal gland --- p.5 / Chapter 1.2 --- Discovery of melatonin --- p.5 / Chapter 1.3 --- Synthesis of melatonin --- p.5 / Chapter 1.4 --- Physiology of melatonin and its derivatives --- p.6 / Chapter 1.5 --- In vitro tumor biology of melatonin and its derivatives --- p.7 / Chapter 1.6 --- In vivo tumor biology of melatonin --- p.10 / Chapter 1.7 --- Macrophages --- p.11 / Chapter 1.8 --- Lymphocytes --- p.14 / Chapter Chapter 2 --- Toxicity of pineal indoles on tumor cell lines / Chapter 2.1 --- General introduction --- p.17 / Chapter 2.2 --- Material and methods --- p.18 / Chapter 2.3 --- Results --- p.22 / Chapter 2.4 --- Discussion --- p.23 / Chapter Chapter 3 --- Activation of murine peritoneal macrophages by melatonin and methoxytryptamine / Chapter 3.1 --- General introduction --- p.37 / Chapter 3.2 --- Material and methods --- p.38 / Chapter 3.3 --- Results --- p.55 / Chapter 3.4 --- Discussion --- p.61 / Chapter Chapter 4 --- Activation of murine splenocytes by melatonin and methoxytryptamine / Chapter 4.1 --- General introduction --- p.81 / Chapter 4.2 --- Material and methods --- p.82 / Chapter 4.3 --- Results --- p.91 / Chapter 4.4 --- Discussion --- p.128 / Chapter Chapter 5 --- General discussion --- p.132 / References

by Chen Paul. / Thesis (M.Phil.)--Chinese University of Hong Kong, 1997. / Includes bibliographical references (leaves 141-150). / Chapter 1. --- INTRODUCTION --- p.1 / Chapter 1.1 --- Immunomodulation --- p.1 / Chapter 1.2 --- Effector cells mediating anti-tumour immunity --- p.1 / Chapter 1.2.1 --- Cytotoxic T Lymphocytes --- p.3 / Chapter 1.2.2 --- Macrophages --- p.4 / Chapter 1.2.3 --- Natural Killer Cells --- p.5 / Chapter 1.2.4 --- Lymphokine-activated Killer (LAK) --- p.6 / Chapter 1.3 --- Cytokines as immunomodulators in cancer therapy --- p.7 / Chapter 1.3.1 --- Tumour Necrosis Factor-α (TNF-α) --- p.7 / Chapter 1.3.2 --- Interleukin-1 (IL-1) --- p.9 / Chapter 1.3.3 --- Interleukin-2 (IL-2) --- p.9 / Chapter 1.3.4 --- Granulocytes/Macrophages Colony-Stimulating Factors --- p.10 / Chapter 1.4 --- Polysaccharides as potential immunostimulating agents --- p.11 / Chapter 1.5 --- General properties of Klebsiella pneumoniae --- p.12 / Chapter 2. --- AIM AND SCOPE OF THIS DISSERTATION --- p.16 / Chapter 3. --- MATERIALS AND METHODS --- p.18 / Chapter 3.1 --- Materials --- p.18 / Chapter 3.1.1 --- Animals --- p.18 / Chapter 3.1.2 --- Klebsiella pneumoniae K24 --- p.18 / Chapter 3.1.3 --- Cell lines --- p.18 / Chapter 3.1.4 --- "Buffer, Culture media and Chemicals" --- p.19 / Chapter 3.2 --- Methods --- p.27 / Chapter 3.2.1 --- Extraction and Characterization of Klebsiella pneumoniae K24 Capsular Polysaccharide (K24 CPS) --- p.27 / Chapter 3.2.2 --- Assays of Immunomodulatory Activities of K24 CPS on Lymphocytes --- p.30 / Chapter 3.2.3 --- Assays of Immunomodulatory Effect of K24 CPS on Macrophages --- p.34 / Chapter 3.2.4 --- Assays of Anti-Tumour Activities of K24 CPS --- p.39 / Chapter 3.2.5 --- Assays of the Effects of K24 CPS on the Proliferation and Differentiation of Murine Bone Marrow Cells --- p.54 / Chapter 3.2.6 --- Assays of the Immunorestorative Activities of K24 CPS --- p.56 / Chapter 4. --- EXTRACTION AND CHARACTERIZATION OF KLEBSIELLA PNEUMONIAE K24 CAPSULAR POLYSACCHARIDE (K24 CPS) --- p.59 / Chapter 4.1 --- Preparation of Klebsiella pneumoniae K24 CPS Capsular Polysaccharide (K24 CPS) --- p.59 / Chapter 4.2 --- Acetic Acid Treatment of K24 CPS --- p.59 / Chapter 4.3 --- Gel Filtration --- p.59 / Chapter 4.4 --- Carbohydrate and Protein contents of K24 CPS --- p.61 / Chapter 4.5 --- Cytotoxicity Assay using Artemia franciscana (Brine Shrimp) --- p.61 / Chapter 5. --- IMMUNOMODULATORY EFFECTS OF K24 CPS --- p.68 / Chapter 5.1 --- The Effect of K24 CPS in vitro Mitogenic Assay of K24 CPS using Murine Splenocytes --- p.68 / Chapter 5.2 --- The in vivo Mitogenic Effect of K24 CPS on Murine Splenic Lymphocytes --- p.73 / Chapter 5.3 --- The Effect of K24 CPS on the Production of Interleukin-2 (IL-2)-like substance by Murine Splenocytes --- p.73 / Chapter 5.4 --- The effect of K24 CPS on the in vitro Stimulation of Murine Macrophage Nitric Oxide (NO) Production --- p.73 / Chapter 5.5 --- The effect of K24 CPS on the in vitro Stimulation of Macrophage Interleukin-1-like Production --- p.77 / Chapter 5.6 --- The effect of K24 CPS on in vivo Migration of Macrophage --- p.82 / Chapter 5.7 --- The effect of K24 CPS in vitro Stimulation of Macrophage Tumour Necrosis Factor- a (TNF-a) Production --- p.82 / Chapter 6. --- IN VITRO ANTI-TUMOUR EFFECT OF K24 CPS --- p.89 / Chapter 6.1 --- The in vitro Cytostatic effect of K24 CPS on the Suppression of EAT growth --- p.89 / Chapter 6.2 --- The effect of K24 CPS on cell cycle of EAT cells --- p.89 / Chapter 6.3 --- Study of the cytostatic effect of K24 CPS on EAT cells using Western Analysis --- p.93 / Chapter 6.3.1 --- Pattern of Phosphotyrosine Proteins --- p.93 / Chapter 6.3.2 --- Pattern of Phosphoserine Proteins --- p.96 / Chapter 6.3.3 --- Pattern of Phosphothreonine Proteins --- p.96 / Chapter 6.3.4 --- Level of c-fos --- p.99 / Chapter 6.3.5 --- Level of c-jun --- p.99 / Chapter 6.3.6 --- Level of c-myc --- p.102 / Chapter 7. --- THE IN VIVO ANTI-TUMOUR ACTIVITIES OF K24 CPS --- p.103 / Chapter 7.1 --- The effect of K24 CPS on the In vivo Suppression of EAT growth --- p.103 / Chapter 7.2 --- The effect of K24 CPS on the survival of EAT-bearing mice --- p.103 / Chapter 7.3 --- The effect of K24 CPS on the in vivo induction of Natural Killer (NK) Cell Cytotoxicity --- p.111 / Chapter 7.4 --- The effect of K24 CPS in vitro induction of Lymphokine-activated Killer (LAK) Cell Cytotoxicity --- p.111 / Chapter 7.5 --- The effect of K24 CPS on the in vivo Induction of Lymphokine-activated Killer (LAK) Cell Cytotoxicity --- p.114 / Chapter 7.6 --- The effect of K24 CPS on the endogenous production of TNF-α --- p.114 / Chapter 7.7 --- The effect of K24 CPS on the endogenous TNF-α production and EAT growthin vivo --- p.117 / Chapter 8. --- THE IMMUNORESTORATIVE ACTIVITIES OF K24 CPS --- p.122 / Chapter 8.1 --- The in vivo Immunorestorative Activities of K24 CPS in EAT-bearing Mice --- p.122 / Chapter 8.2 --- The in vitro Immunorestorative Activities of K24 CPS in Mice bearing 10-day-old- EAT --- p.122 / Chapter 9. --- THE EFFECT OF K24 CPS IN VITRO INDUCTION OF MURINE BONE MARROW CELLS PROLIFERATION AND DIFFERENTIATION --- p.126 / Chapter 9.1 --- The effect of K24 CPS in vitro induction of Murine Bone Marrow Cells Proliferation --- p.126 / Chapter 9.2 --- The effect of K24 CPS in vitro induction of Murine Bone Marrow Cells Differentiation --- p.126 / Chapter 10. --- CONCLUSIONS AND FUTURE PERSPECTIVES --- p.135 / Chapter 11. --- BIBLIOGRAPHY --- p.141

by Kok Dick Shun, Louis. / Thesis (M.Phil.)--Chinese University of Hong Kong, 1993. / Includes bibliographical references. / Acknowledgements --- p.I / Table of Contents --- p.II / Abbreviations --- p.V / Aim and Scope of This Dissertation --- p.IX / Abstract --- p.X / Chapter Chapter One： --- General Introduction --- p.1 / Chapter 1.1 --- An Overview of the Immune System --- p.2 / Chapter 1.1.1 --- Innate Immunity --- p.2 / Chapter 1.1.2 --- Adaptive Immunity --- p.3 / Chapter 1.1.2.1 --- Humoral antibody immune response --- p.4 / Chapter 1.1.2.2 --- Cell- mediated immune response --- p.5 / Chapter 1.2 --- Immunomodulation --- p.6 / Chapter 1.3 --- An overview of the Host-mediated response against tumours --- p.9 / Chapter 1.3.1 --- T and B lymphocytes --- p.9 / Chapter 1.3.2 --- M acrophages --- p.14 / Chapter 1.3.3 --- Natural killer cells --- p.17 / Chapter 1.3.4 --- Lymphokines-activated killer cells --- p.20 / Chapter 1.3.5 --- Tumour infiltrating lymphocytes --- p.22 / Chapter 1.3.6 --- Cytokines --- p.23 / Chapter 1.4 --- Carbohydrates as Potential Immunostimulating agents --- p.33 / Chapter 1.5 --- General Properties of Bupleuri radix (B.R.) --- p.35 / Chapter Chapter Two： --- Materials and Methods --- p.36 / Chapter 2.1 --- Materials --- p.37 / Chapter 2.1.1 --- Animals --- p.37 / Chapter 2.1.2 --- Bupleuri radix --- p.37 / Chapter 2.1.3 --- "Buffers, culture media and chemicals" --- p.37 / Chapter 2.1.4 --- Cell lines --- p.48 / Chapter 2.2 --- Methods --- p.49 / Chapter 2.2.1 --- Extraction and fractionation of Bupleuri radix --- p.49 / Chapter 2.2.2 --- Purification of Bupleuri radix --- p.54 / Chapter 2.2.3 --- Characterization of Bupleuri radix --- p.55 / Chapter 2.2.4 --- In vivo Drug Treatment --- p.59 / Chapter 2.2.5 --- Isolation and preparation of cells --- p.59 / Chapter 2.2.6 --- Assays for the immunomodulatory activities of Bupleuri radix --- p.62 / Chapter 2.2.7 --- Assays for the immunorestorative properties of Bupleuri radix --- p.74 / Chapter 2.2.8 --- Assays for the anti-tumour activities of Bupleuri radix --- p.75 / Chapter 2.2.9 --- Statistical analysis --- p.83 / Chapter Chapter Three： --- "Fractionation, Purification and Characterization of Bioactive Compounds from Bupleuri radix" --- p.84 / Chapter 3.1 --- Results / Chapter 3.1.1 --- Extraction and Fractionation of Bupleuri radix --- p.85 / Chapter 3.1.2 --- Purification of Bupleuri radix --- p.85 / Chapter 3.1.3 --- Carbohydrate and Protein Contents of B.R. Fractions --- p.87 / Chapter 3.1.4 --- Lack of cytotoxicity of Bupleuri radix to Mouse Splenocytes --- p.91 / Chapter 3.1.5 --- LC50 of B.R. Fractions determined by Brine Shrimp Bioassay --- p.91 / Chapter 3.1.6 --- Heat stability of B.R. Fractions --- p.93 / Chapter 3.1.7 --- "Uronic Acid Content of BRIai, BRIaii, BRIbi and BRIbii" --- p.93 / Chapter 3.2 --- Discussion --- p.93 / Chapter Chapter Four： --- The Immunomodulatory Activities of Bupleuri radix --- p.96 / Chapter 4.1 --- Results / Chapter 4.1.1 --- Effect of Bupleuri radix on the Specific and Nonspecific Immunity --- p.97 / Chapter 4.1.1.1 --- Mitogenic effect of B.R. Fractions on Murine Splenocytes in vitro --- p.97 / Chapter 4.1.1.2 --- Mitogenic effect of B.R. Fractions on Murine Splenocytes ex vivo --- p.97 / Chapter 4.1.1.3 --- In vitro Mitogenic effect of B.R. Fractions treated with Periodate --- p.103 / Chapter 4.1.1.4 --- In vitro Mitogenic effect of B.R. Fractions treated with Acetic Acid --- p.103 / Chapter 4.1.1.5 --- In vitro Co -mitogenic effect of B.R. Fractions with Polymyxin B Sulphate --- p.107 / Chapter 4.1.1.6 --- Effect of B.R. Fractions on Lymphocyte sub-populations --- p.107 / Chapter 4.1.1.7 --- Primary Humoral Immune Response to SRBC in B.R.-treated mice --- p.107 / Chapter 4.1.1.8 --- Activity of cytotoxic T cells in B.R-treated mice --- p.111 / Chapter 4.1.1.9 --- Effect of B.R. Fractions on Interleukin-1 - like Factors Production --- p.111 / Chapter 4.1.1.10 --- Effect of B.R. Fractions on Interleukin-2 Production --- p.116 / Chapter 4.1.1.11 --- Effect of B.R. Fractions on Interleukin-2 Receptor Expression on Murine Splenocytes --- p.116 / Chapter 4.1.1.12 --- Effect of B.R. Fractions on GM-CSF Production --- p.119 / Chapter 4.1.1.13 --- Immunopotentiating effects of B.R. Fractions on Macrophages: --- p.119 / Chapter 4.1.1.13.1 --- In vivo Migration of Macrophages in B.R.-treated mice --- p.119 / Chapter 4.1.1.13.2 --- Effect of B.R. Fractions on the Fc Receptor Expression on Murine Resident Peritoneal Exudate Cells --- p.123 / Chapter 4.1.2 --- Immunorestorative Properties of Bupleuri radix --- p.123 / Chapter 4.1.2.1 --- Effect of B.R. Fractions on Lymphocyte Blastogenesis in Aged Mice --- p.123 / Chapter 4.1.2.2 --- Effect of B.R. Fractions on Lymphocyte Blastogenesis in Tumour-bearing Mice --- p.125 / Chapter 4.2 --- Discussion --- p.125 / Chapter Chapter Five： --- The Anti-tumour Activities of Bupleuri radix --- p.132 / Chapter 5.1 --- Results / Chapter 5.1.1 --- Cytostatic Effect of B.R. Fractions on Murine Tumour Cell Lines in vitro --- p.133 / Chapter 5.1.2 --- Effect of B.R. Fractions on the Growth of Tumour Ceils in vivo --- p.133 / Chapter 5.1.3 --- Effect of B.R. Fractions on the Survival of EAT-bearing mice --- p.140 / Chapter 5.1.4 --- Ex vivo Induction of Natural Killer Cell Activity by B.R. Fractions --- p.146 / Chapter 5.1.5 --- In vitro Induction of Lymphokine-activated Killer Cell Activity by B.R Fractions --- p.149 / Chapter 5.1.6 --- In vivo Induction of Tumour Infiltrating Lymphocytes by B.R. Fractions --- p.149 / Chapter 5.1.7 --- In vitro Induction of Macrophage-mediated Cytostatic Effect on Tumour Cells by B.R. Fractions --- p.151 / Chapter 5.1.8 --- In vitro Induction of Macrophage-mediated Cytostatic Eifect on Tumour Cells by B.R. Fractions --- p.153 / Chapter 5.1.9 --- Effect of B.R. Fractions on γ-interferon Production in vitro --- p.156 / Chapter 5.2 --- Discussion --- p.156 / Chapter Chapter Six： --- "General Discussion, Conclusion and Future Prospects" --- p.164 / Bibliography --- p.i