Ko Mui Lam. / Thesis submitted in: December 2003. / Thesis (M.Phil.)--Chinese University of Hong Kong, 2004. / Includes bibliographical references (leaves 84-100). / Abstracts in English and Chinese. / Chapter Chapter 1 --- Introduction --- p.1 / Chapter A. --- Antibiotic use and resistance --- p.1 / Chapter B. --- Selection of resistant strains by antibiotics --- p.2 / Chapter C. --- Fluoroquinolones --- p.5 / Chapter D. --- β-Lactams --- p.8 / Chapter E. --- Aminoglycosides --- p.9 / Chapter F. --- Salmonella sp --- p.9 / Chapter a. --- Microbiology and clinical significance --- p.9 / Chapter b. --- Antimicrobial susceptibilities --- p.10 / Chapter G. --- Escherichia coli --- p.14 / Chapter a. --- Microbiology and clinical significance --- p.14 / Chapter b. --- Antimicrobial susceptibilities --- p.15 / Chapter H. --- Pseudomonas aeruginosa --- p.18 / Chapter a. --- Microbiology and clinical significance --- p.18 / Chapter b. --- Antimicrobial susceptibilities --- p.18 / Chapter I. --- Objectives --- p.22 / Chapter Chapter 2 --- Materials and Methods --- p.23 / Chapter A. --- Bacterial strains --- p.23 / Chapter B. --- Methods --- p.23 / Chapter a. --- Identification --- p.23 / Chapter i) --- Salmonella --- p.23 / Chapter ii) --- Escherichia coli --- p.24 / Chapter iii) --- Pseudomonas aeruginosa --- p.24 / Chapter b. --- Antimicrobial susceptibility testing --- p.24 / Chapter i) --- Determination of minimal inhibitory concentrations (MICs) of antibiotics --- p.24 / Chapter ii) --- "Determination of the antimicrobial susceptibility of Salmonella sp, Escherichia coli and Pseudomonas aeruginosa by the breakpoint method" --- p.28 / Chapter c. --- Effects of antimicrobial agents on the development of resistant mutants --- p.28 / Chapter Chapter 3 --- Results --- p.32 / Chapter A. --- Antimicrobial susceptibilities --- p.32 / Chapter B. --- Effects of fluoroquinolones on the development of resistance --- p.36 / Chapter a. --- Salmonella sp --- p.38 / Chapter b. --- Escherichia coli --- p.40 / Chapter c. --- Pseudomonas aeruginosa --- p.46 / Chapter C. --- Effects of β-lactams on the development of resistance --- p.49 / Chapter a. --- Salmonella sp --- p.49 / Chapter b. --- Escherichia coli --- p.53 / Chapter c. --- Pseudomonas aeruginosa --- p.56 / Chapter D. --- Effects of aminoglycosides on the development of resistance --- p.60 / Chapter a. --- Salmonella sp --- p.60 / Chapter b. --- Escherichia coli --- p.68 / Chapter c. --- Pseudomonas aeruginosa --- p.68 / Chapter Chapter 4 --- Discussion --- p.76 / References --- p.84 / List of Tables / Chapter I-1 --- Antimicrobial susceptibilities of salmonellae reported in the literature --- p.12 / Chapter I-2 --- Antimicrobial susceptibilities of Escherichia coli reported in the literature --- p.16 / Chapter I-3 --- Antimicrobial susceptibilities of Pseudomonas aeruginosa reported in the literature --- p.20 / Chapter II-1 --- Antibiotics and their solvents --- p.26 / Chapter II-2 --- Antibiotics and their concentrations tested --- p.27 / Chapter II-3 --- Antibiotics and their breakpoint concentration tested --- p.29 / Chapter III-1 --- Susceptibilities of 40 isolates of Salmonella sp to 12 antimicrobial agents --- p.33 / Chapter III-2 --- Susceptibilities of 40 isolates of Escherichia coli to 12 antimicrobial agents --- p.34