No description available.

These two studies investigate the immune responses of lung and kidney transplant recipients to the influenza vaccine. The study involving kidney transplant recipients developed a novel flow cytometry assay to measure cell-mediated immunity in response to influenza vaccination. The activation of T-cells was assessed through the change in T-cell production of interferon gamma after vaccination. In lung transplant recipients, the study examined the formation of de novo anti-HLA antibodies following influenza vaccination. Anti-HLA antibodies were classified as donor-specific or not. The study in kidney transplant recipients found that the influenza vaccine is effective at stimulating the immune response and producing long-lived memory in these patients, as evidenced by high baseline T-cell activity. The study of lung transplant recipients found that receiving the influenza vaccine did not result in the production of anti-HLA antibodies. Both studies found vaccine to be safe for use in these populations. / Experimental Medicine

京都大学 / 0048 / 新制・課程博士 / 博士(医学) / 甲第20258号 / 医博第4217号 / 新制||医||1020(附属図書館) / 京都大学大学院医学研究科医学専攻 / (主査)教授 小西 靖彦, 教授 平家 俊男, 教授 中畑 龍俊 / 学位規則第4条第1項該当 / Doctor of Medical Science / Kyoto University / DFAM